Protein Alignment bgcn and DHX37

DIOPT Version :10

• Sequence 1: NP_523832.2
• Gene: bgcn / 47873
• FlyBaseID: FBgn0004581
• Length: 1215
• Species: Drosophila melanogaster
• Sequence 2: XP_005253647.1
• Gene: DHX37 / 57647
• HGNCID: 17210
• Length: 1175
• Species: Homo sapiens
• Alignment Length: 890
• Identity: 168/890 - (18%)
• Similarity: 313/890 - (35%)
• Gaps: 241/890 - (27%)

  Fly   114 ANASDLP-SLHLP---LPAIRPPNLRFWTEAQLNFLTAFLGHSLSDE--ILQSLYASRVIVYNAA 172
            |.|..|| :|..|   :|..|.|.::   |.:|..      ..||:|  |::::....:::....
Human   221 AAAPPLPRALAKPAVFIPVNRSPEMQ---EERLKL------PILSEEQVIMEAVAEHPIVIVCGE 276

  Fly   173 LCWDKSVFLPLVILDDCRNKKSNVKIMCIERQAILATYNSQRTANFFGEQLG---ETVGIQLPYF 234
            ....|:..:|..:.:...:.:.:: |...|.:.:.|...|||.|    :::.   ..|..|:.|.
Human   277 TGSGKTTQVPQFLYEAGFSSEDSI-IGVTEPRRVAAVAMSQRVA----KEMNLSQRVVSYQIRYE 336

  Fly   235 SAVSSSTFIIYSTAQYFLRSLTSQQFRNISH--LVVNDVHLHDPYTDI---LLSEIRMALSSHQN 294
            ..|:..|.|.:.|....|:.: .:.|..:.:  :::::.|....||||   |||.| :.|.:.:|
Human   337 GNVTEETRIKFMTDGVLLKEI-QKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRI-VTLRAKRN 399

  Fly   295 LRVVLLSQMG---------NPKKFTDFFGEGLQLNMIKQPEVAPRVSYLNELHSCIALAGIHKGP 350
            |.:.||....         ||:.|.            |.|.|....|
Human   400 LPLKLLIMSATLRVEDFTQNPRLFA------------KPPPVIKVES------------------ 434

  Fly   351 DIYKEIPEA--FRANNPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPV-NYRHSLTGKTAV 412
               ::.|..  |....|..:...:|.:...::              :.:.|. .....|||:..|
Human   435 ---RQFPVTVHFNKRTPLEDYSGECFRKVCKI--------------HRMLPAGGILVFLTGQAEV 482

  Fly   413 H-FASELNKANHLRLLLF--MGADPYIVDLFQQNAIS---------LAAMNGNHECIDVLN--SY 463
            | ....|.||       |  ..|.|...|..|::::.         ..|.....|.:..:|  .|
Human   483 HALCRRLRKA-------FPPSRARPQEKDDDQKDSVEEMRKFKKSRARAKKARAEVLPQINLDHY 540

  Fly   464 SL----HGYVVKSAKPD----FVDYDLIIDIMYLLRTKPEYSPGEYSPGNI-LIILPTYYHIVKL 519
            |:    .|...:.|:.|    .:|.||.:|:     .......||....:: |.:||.|
Human   541 SVLPAGEGDEDREAEVDEEEGALDSDLDLDL-----GDGGQDGGEQPDASLPLHVLPLY------ 594

  Fly   520 NYMILSHCLTGSLQECSIFLLYDNMRNDYLQALVNASDETVKVVLATDIIESLCLKVP-FKYQID 583
                   .|....::..:|              ....:.|...|:||::.|: .|.:| .||.:|
Human   595 -------SLLAPEKQAQVF--------------KPPPEGTRLCVVATNVAET-SLTIPGIKYVVD 637

  Fly   584 TACRLNNVYDTTSCSGDDRFEWVAK---DALLRRELILQPNKGDVQCFRLISKEAYEELSETSQP 645
            ........||..:.....|..||::   |....|....:|.    .|:||.|...:.:..:...|
Human   638 CGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPG----HCYRLYSSAVFGDFEQFPPP 698

  Fly   646 SLQTMQLDKICLAVKLLSPNTIISEYLGITISPPPLINVHHAVQFL----------KKIDVLDDA 700
            .:....::.:.|.:|.|:    :.:.:......||.:....|.:.|          :|.:.:...
Human   699 EITRRPVEDLILQMKALN----VEKVINFPFPTPPSVEALLAAEELLIALGALQPPQKAERVKQL 759

  Fly   701 ED------VTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPFTEDIDNL 759
            ::      :|.||..:...||:.:..:||.......||...:|||:|::..:     ..|::|
Human   760 QENRLSCPITALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVASMTVRE-----LFEELD-- 817

  Fly   760 WDRFTIYIQNSIKKERTYLSDNQF----SDHFIFVRLYKEWQNRMHNRTPPLYLKD--------- 811
                           |...||.:.    |......::.:.|.    .:...|.|.|
Human   818 ---------------RPAASDEELTRLKSKRARVAQMKRTWA----GQGASLKLGDLMVLLGAVG 863

  Fly   812 --EY-----EFM-LNGL----MEQLTSIRSEIVSSLRA----ANLIHSRGKLSMNNLNQMSCNWH 860
              ||     :|. .|||    |.::..:|.::.:::.|    |.|... .|:.....:|::....
Human   864 ACEYASCTPQFCEANGLRYKAMMEIRRLRGQLTTAVNAVCPEAELFVD-PKMQPPTESQVTYLRQ 927

  Fly   861 MVKAALTGGMYPNIYAVDTRKSSLKSAF-----SGNVSMHPNTVL 900
            :|.|.|...:...:.:.:..:...::|:     ...|.:||::||
Human   928 IVTAGLGDHLARRVQSEEMLEDKWRNAYKTPLLDDPVFIHPSSVL 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	DEAD-like_helicase_N	155..314	CDD:475120	37/177 (21%)
		ANKYR	<398..>460	CDD:440430	16/74 (22%)
		ANK repeat	406..438	CDD:293786	11/34 (32%)
		P-loop containing Nucleoside Triphosphate Hydrolases	465..>594	CDD:476819	26/138 (19%)
		HA2	687..789	CDD:461295	22/121 (18%)
		OB_NTP_bind	862..945	CDD:400182	9/44 (20%)
DHX37	XP_005253647.1	HrpA	252..>1043	CDD:441249	157/856 (18%)