Protein Alignment bgcn and DHX33

DIOPT Version :10

• Sequence 1: NP_523832.2
• Gene: bgcn / 47873
• FlyBaseID: FBgn0004581
• Length: 1215
• Species: Drosophila melanogaster
• Sequence 2: NP_064547.2
• Gene: DHX33 / 56919
• HGNCID: 16718
• Length: 707
• Species: Homo sapiens
• Alignment Length: 740
• Identity: 134/740 - (18%)
• Similarity: 255/740 - (34%)
• Gaps: 237/740 - (32%)

  Fly   201 IERQAILATYNSQRTANFF---------GEQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLR-SL 255
            |.||.|:|....:|.|...         ..:||:.||..:.:....|..|.|.:.|....|| ::
Human   116 ISRQGIIAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFDDVTSEDTRIKFLTDGMLLREAI 180

  Fly   256 TSQQFRNISHLVVNDVHLHDPYTDILLSEIRMALSSHQN-----LRVVLLSQMGNPKKFTDFFGE 315
            :....|..|.:::::.|....:||:|...::.|....:.     |:|:::|...:...|:.:|..
Human   181 SDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKELGKLPLKVIVMSATMDVDLFSQYFNG 245

  Fly   316 GLQLNMIKQPEVAPRVSYLNELHSCIALAGIHKGPDIYKEIPEAFRANNPRNEQMDKCL----QA 376
                        || |.||......|                :.|....|:|:.:...|    |.
Human   246 ------------AP-VLYLEGRQHPI----------------QVFYTKQPQNDYLHAALVSVFQI 281

  Fly   377 YGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNK--ANHLRLLLFMGADPYIVDL 439
            :.|..:...:..|                |||:..:...|:..:  |.||
Human   282 HQEAPSSQDILVF----------------LTGQEEIEAMSKTCRDIAKHL--------------- 315

  Fly   440 FQQNAISLAAMNGNHECIDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRTKPEYSPGEYSPG 504
                                                                  |:..|.
Human   316 ------------------------------------------------------PDGCPA----- 321

  Fly   505 NILIILPTYYHIVKLNYMILSHCLTGSLQECSIFLLYDNMRNDYLQALVNASDETVKVVLATDII 569
              :::||.|   ..|.|          .|:..:|              ..|.....||:::|:|.
Human   322 --MLVLPLY---ASLPY----------AQQLRVF--------------QGAPKGYRKVIISTNIA 357

  Fly   570 ESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLRRELILQPNKGDVQ----CFRL 630
            |:.......||.:||.......|:.     |...|.:|...:.:.:...:..:...:    |:||
Human   358 ETSITITGIKYVVDTGMVKAKKYNP-----DSGLEVLAVQRVSKTQAWQRTGRAGREDSGICYRL 417

  Fly   631 ISKEAYEELSETSQPSLQTMQLDKI---CLAVKLLSPNTIISEYLGITISPPPLINVHHAVQFLK 692
            .:::.:|:..:.:.|.:|...|..:   .||:|:  ||.:..:::.   .|.|    .|....:.
Human   418 YTEDEFEKFDKMTVPEIQRCNLASVMLQLLAMKV--PNVLTFDFMS---KPSP----DHIQAAIA 473

  Fly   693 KIDVL------DDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIP 751
            ::|:|      ||...:|.:|.::...|:..:..:.::......|.:.||||||.||....|..|
Human   474 QLDLLGALEHKDDQLTLTPMGRKMAAFPLEPKFAKTILMSPKFHCTEEILTIVSLLSVDSVLHNP 538

  Fly   752 FT--EDIDNLWDRFTIYIQNSIKKERTYLSDNQFSDHFIFVRLYKEWQNRMHNRTPPLYLKDEYE 814
            .:  |::..:..:|       |..|         .||...:.:|:.::|...|:.   :.|:.:.
Human   539 PSRREEVQGVRKKF-------ISSE---------GDHMTLLNIYRTFKNLGGNKD---WCKENFV 584

  Fly   815 FMLNGLMEQLTSIRSEI--VSSLRAANLIHSRGKLSMNNLNQMSCNWHMVKAALTGGMYPN-IYA 876
            ...|  |..:..:|:::  :....:..:..|||.:.    :...|..|.:..: |..:.|: .||
Human   585 NSKN--MTLVAEVRAQLRDICLKMSMPIASSRGDVE----SVRRCLAHSLFMS-TAELQPDGTYA 642

  Fly   877 -VDTRKSSLKSAFSGNVSMHPNTVL 900
             .||.:.         |::||::||
Human   643 TTDTHQP---------VAIHPSSVL 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	DEAD-like_helicase_N	155..314	CDD:475120	28/127 (22%)
		ANKYR	<398..>460	CDD:440430	7/63 (11%)
		ANK repeat	406..438	CDD:293786	7/33 (21%)
		P-loop containing Nucleoside Triphosphate Hydrolases	465..>594	CDD:476819	20/128 (16%)
		HA2	687..789	CDD:461295	24/109 (22%)
		OB_NTP_bind	862..945	CDD:400182	11/41 (27%)
DHX33	NP_064547.2	Required for nucleolar location. /evidence=ECO:0000269|PubMed:26100019	1..80
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..64
		HrpA	73..>700	CDD:441249	134/740 (18%)
		DEAH box	194..197		0/2 (0%)
		HA2, required for interaction with EIF3G and RPL26. /evidence=ECO:0000269|PubMed:26100019	471..562		24/106 (23%)
		Critical for rDNA-binding. /evidence=ECO:0000250	547..558		3/26 (12%)