Protein Alignment bgcn and ythdc2

DIOPT Version :10

• Sequence 1: NP_523832.2
• Gene: bgcn / 47873
• FlyBaseID: FBgn0004581
• Length: 1215
• Species: Drosophila melanogaster
• Sequence 2: XP_021332046.1
• Gene: ythdc2 / 567114
• ZFINID: ZDB-GENE-220119-1
• Length: 1381
• Species: Danio rerio
• Alignment Length: 1378
• Identity: 336/1378 - (24%)
• Similarity: 563/1378 - (40%)
• Gaps: 289/1378 - (20%)

  Fly    27 FPCTFRTSEHEAFANNARSLGLRSQVVHVNGNSCVKVYKQACRHYLEEPKTLV---LSSGATLNM 88
            ||.:...||.......|:|||..|:   ..|..|.:......:..:|..::.:   ||......:
Zfish    56 FPSSLTNSERAFIHRLAQSLGYISK---SRGKGCSRFLTVRKKDGMEAQRSSMSCSLSPSCRALV 117

  Fly    89 FTLLSRKSLMGKEDLELY----------ADLVSMKANASDLPSLHLPLPAIRPPNLRFWTEAQLN 143
            .:|:.|..:..:|..:|.          .|....|:..|...|..:|..   ||  |..:..:|:
Zfish   118 QSLMQRFPISSRERSQLQPHAERGLQSPPDTTDSKSRTSGRLSHGIPQV---PP--RRSSAPELD 177

  Fly   144 -FLTAFLGHSLSDEILQSLYASRVIVYNAALCWDKSVFLPLVILDDCRNKKSNVKIMCIERQAIL 207
             |..|...:.|.::|:||:...:|::........|:..:|..:||||....|..:|.|.:.:.:.
Zfish   178 AFRKALPVYELQEQIIQSIRDHQVVLVLGETGSGKTTQIPQFLLDDCSATASPCRIFCTQPRRLA 242

  Fly   208 ATYNSQRTANFFGEQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLRSLTS--QQFRNISHLVVND 270
            ....::|.|...||.:|:|||.|:...|.||..|.:.:.|:...||:|.:  :....::|::|::
Zfish   243 TIAVAERVAAERGENIGQTVGYQIRLESRVSPKTLLTFCTSGVLLRTLMAGDEALSTVTHVIVDE 307

  Fly   271 VHLHDPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFG------------EGLQL---- 319
            ||..|..||.||::::..|....|||:||.|...:...|..:||            |..||
Zfish   308 VHERDGLTDFLLTKMKEVLQKMPNLRLVLSSAALDVSLFMRYFGSCPVIHIKGCPYEVKQLFLED 372

  Fly   320 ----------NMIKQPEVAPRVSYLNELHSCIALAGIHKGPDIYKEIPEAFRANNPR------NE 368
                      :|||..:.|.:    .|...|.......      :::|:|.....|.      |:
Zfish   373 ILRSTAYTNKDMIKYKKEAQK----EESQQCSLSEWCE------RDVPQADPPERPTVCVLQDNQ 427

  Fly   369 ---------------------------QMDKCLQA-YGELGTDAALRPFLYAVNYDLAPVNYRHS 405
                                       :||.|:.: :.....||..:.|...:|.::: |:||||
Zfish   428 LLDDGGDSVFSQMSEKDVSSLEPWLLREMDSCISSIFLNQDADAFTQLFNLILNENIS-VDYRHS 491

  Fly   406 LTGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNG-------NH----ECIDV 459
            .|..||:..::.....:|...||.|||:           |::.|.||       .|    |.:|:
Zfish   492 ETSATALMVSAGRGFVSHTEQLLNMGAN-----------INIKASNGWTALDWAKHFKQTEAVDL 545

  Fly   460 LNSYSLHGYVVKSAKPDFV-------------DYDLI-----------ID---IMYLLRTKPEYS 497
            |.|   |.:..:::..|..             |.:|:           :|   |::||.:..:.|
Zfish   546 LES---HIWCAEASPQDEASLLQNSSCELSCEDQELLKAYHHSFDDEKVDLQLILHLLHSICQSS 607

  Fly   498 PGEYSPGNILIILPTYYHIVKLNYMIL--SHCLTGSLQECSIFLLYDNMR-NDYLQALVNASDET 559
                ..|.:||.||.|..||.|...||  ....|...|...:|:|:.:|: :|..:.|.:.....
Zfish   608 ----DQGAVLIFLPGYDEIVSLRDQILFDDKRFTEHQQRFQVFVLHSSMQTSDQKKVLKSTPKGV 668

  Fly   560 VKVVLATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLRRELILQPNKGD 624
            .|::|:|:|.|:........:.||:.......||..:.....:..|::|.:.|:|       ||.
Zfish   669 RKIILSTNIAETSITVSDVVFVIDSGKVKEKAYDALNNVTMLKMVWISKASALQR-------KGR 726

  Fly   625 V------QCFRLISKEAYEELSETSQPSLQTMQLDKICLAVKLLSP-NTIISEYLGITISPPPLI 682
            .      .||.|.|:..:..:.|...|.|..|.|.::||..|||:| |..::|:|.....||.:.
Zfish   727 AGRCRPGVCFHLFSRLRFSNMLEHQIPQLLRMPLQELCLHTKLLAPINCPVAEFLSRAPEPPHIN 791

  Fly   683 NVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADP 747
            .|.||||.||.||.:|..|::|.||..|.|:||...||:|::..::|:||||:|||..:|:..:|
Zfish   792 TVKHAVQMLKTIDAMDPWENLTELGLHLADLPVEPHLGKMVLCAVVLKCLDPVLTIACTLAHREP 856

  Fly   748 LGIPFTEDIDNLWDRFTIYIQNSIKKE----RTYLSDNQFSDHFIFVRLYKEWQNRMHNRTPPLY 808
            ..:|               .|.:.::.    |...:.|.||||...:|.::.||....:.....:
Zfish   857 FVLP---------------AQAAQRRVAMLCRRRFTANTFSDHMALLRAFQAWQKARSDGWERAF 906

  Fly   809 LKDEYEFMLNGLMEQLTSIRSEIVSSLRAANLIHSRGKLSMNNLNQMSCNWHMVKAALTGGMYPN 873
            .  |..|:....||.:.|:|::::..|||...:.:||...:.::||.|.||.:|||||..|||||
Zfish   907 C--EKNFLSQATMEIIVSMRTQLLGQLRATGFVRARGGGDIRDVNQNSENWAVVKAALVAGMYPN 969

  Fly   874 IYAVDTRKSSLKSAFSGNVSMHPNTVLRD----FLEPLN---ISAQSFRTPWIVCNRQ-KSHIVY 930
            :...|  ..||.......|.:||.:||..    .:.|.|   .:..|..|.|::.:.. ::|.:.
Zfish   970 LIHRD--GLSLSGEKEKKVRLHPTSVLSQPQYKKIPPANGQAAAVDSLPTDWLIYDEMTRAHRIA 1032

  Fly   931 A----TLVVPLAVAMFSGHPRIRLSPI------------CDSEM--SLTDRNVNVFIDEWIWMVM 977
            :    |.|.||.:|:|.|..::..|.:            .|||:  ..:.|..::.:|.||...:
Zfish  1033 SVRCCTAVTPLTIALFGGGAKLPSSALQEAVLQRGSADSSDSEVEDQCSARQAHLTLDHWINFRL 1097

  Fly   978 SKATAEMV--MRTRY--YFFKMYHDLLKHCSELDMWRRDCEPVSQYTVLTDTLSKIFESEDGFVG 1038
            ...|||:|  :|.|:  .|.:......|.||:||          :.|:  .||..:..:|:...|
Zfish  1098 DPETAELVFGLRQRWQSVFLRRIRSPSKACSQLD----------ESTI--RTLVSVLSAEEQSAG 1150

  Fly  1039 FFKPPPITFLPTP---QLPSLYLLSVNAHFSWAREVEENMLSKP--------------HHFNSHF 1086
            ..:|..|...|.|   :..|.|..:.....:.|...::...:.|              ||  |..
Zfish  1151 LQQPTGIGQRPRPVSAEDSSSYTHTHGRSRNTADTPQQEATASPDRPRLASQLKNPRMHH--SRH 1213

  Fly  1087 IERQFFVLYAGGDCEEFHSRNTPAFIESVLGKFVRPIDTPNRHIFVILYRKDPDMMLSISRAKFV 1151
            .|...      ..|.......:|:.....:...||   .|:..:...:.:......:.:|:.:.|
Zfish  1214 QEEDL------APCGISEGPTSPSTALVSMSACVR---APHSSVRYFIMKSSNPRNIELSQQRSV 1269

  Fly  1152 -----NGVFMLQEYFRNNIPVFEILDACVSLNVQ-TPVFDG--RLMSALIDKR--------VGNL 1200
                 |....|...|:|:..||.:      .:|| :..|.|  |:.||:..:|        :|.:
Zfish  1270 WSTTPNNEQKLNRAFQNSSAVFLV------FSVQGSGHFQGYARMTSAVSSERCLDFGSSGLGGV 1328

  Fly  1201 IMELFAFRHHWIH 1213
                  |...|||
Zfish  1329 ------FSVQWIH 1335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	DEAD-like_helicase_N	155..314	CDD:475120	47/160 (29%)
		ANKYR	<398..>460	CDD:440430	21/72 (29%)
		ANK repeat	406..438	CDD:293786	9/31 (29%)
		P-loop containing Nucleoside Triphosphate Hydrolases	465..>594	CDD:476819	35/158 (22%)
		HA2	687..789	CDD:461295	37/105 (35%)
		OB_NTP_bind	862..945	CDD:400182	30/94 (32%)
ythdc2	XP_021332046.1	R3H_DEXH_helicase	36..94	CDD:100077	11/40 (28%)
		PRK11131	169..>1003	CDD:182986	235/888 (26%)
		DEXHc_YTHDC2	183..358	CDD:350745	50/174 (29%)
		ANKYR	<473..>549	CDD:440430	25/90 (28%)
		ANK repeat	496..524	CDD:293786	9/38 (24%)
		SF2_C_RHA	584..739	CDD:350178	40/165 (24%)
		OB_NTP_bind	958..1050	CDD:400182	30/93 (32%)
		YTH	1249..1378	CDD:410979	21/99 (21%)