DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and DHX29

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_061903.2	Gene:	DHX29 / 54505	HGNCID:	15815	Length:	1369	Species:	Homo sapiens

Alignment Length:	969	Identity:	211/969 - (21%)
Similarity:	362/969 - (37%)	Gaps:	260/969 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 SRKSLMGKEDLELYADLVSMKANASDLPSLHLPLPAIR--PPNLRFWTEAQLNFLTAFLGHSLSD 155
            |.::|:..||   ::.|....||..||..:......::  |...:...|.|.  |..|   ...|
Human   523 SWENLVSDED---FSALSLESANVEDLEPVRNLFRKLQSTPKYQKLLKERQQ--LPVF---KHRD 579

  Fly   156 EILQSLYASRVIVYNAALCWDKSVFLPLVILDDC---RNKKSNVKIMCIERQAILATYNSQRTAN 217
            .|:::|...||:|........||..:|..:|:|.   ..:.|...|:|.:.:.|.|...:.|..:
Human   580 SIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNEWEASKCNIVCTQPRRISAVSLANRVCD 644

  Fly   218 FFGEQLG-----ETVGIQLPYFSAVSSSTFIIYSTAQYFLRSLTSQ-QFRNISHLVVNDVHLHDP 276
            ..|.:.|     ...|.|:...|....||.::|.|....||.|... ...|:||::|::||....
Human   645 ELGCENGPGGRNSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSV 709

  Fly   277 YTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFF---------GEGLQLNMIKQPEVAPRVS 332
            .:|.||..::..|....:|.::|:|...:.:||:.:|         |....:.:....::.....
Human   710 QSDFLLIILKEILQKRSDLHLILMSATVDSEKFSTYFTHCPILRISGRSYPVEVFHLEDIIEETG 774

  Fly   333 YLNELHS--CIALAGIHKGPDIYKEIPEAFRANNPRNEQMDKCLQAYGELGTDAALRPFLYAVNY 395
            ::.|..|  |          ..:.|..|....|........|..|.|..:.|.|         :.
Human   775 FVLEKDSEYC----------QKFLEEEEEVTINVTSKAGGIKKYQEYIPVQTGA---------HA 820

  Fly   396 DLAPVNYRHSLTGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVL 460
            ||.|...::|             ::..|  .:|:|
Human   821 DLNPFYQKYS-------------SRTQH--AILYM------------------------------ 840

  Fly   461 NSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILS 525
                         .|..::.|||::::..|...|::...|   |.:||.||...||.:
Human   841 -------------NPHKINLDLILELLAYLDKSPQFRNIE---GAVLIFLPGLAHIQQ------- 882

  Fly   526 HCLTGSLQECSIFLLYDNMRND-----------YLQALVNASDETV----------KVVLATDII 569
                          |||.:.||           .|.::::..|:..          |:||||:|.
Human   883 --------------LYDLLSNDRRFYSERYKVIALHSILSTQDQAAAFTLPPPGVRKIVLATNIA 933

  Fly   570 ESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLRRELILQPNKGDVQ---CFRLI 631
            |:........:.|||.....|.|..:|........:|:|.:.|:|    |...|.|:   |||:.
Human   934 ETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETFVSKASALQR----QGRAGRVRDGFCFRMY 994

  Fly   632 SKEAYEELSETSQPSLQTMQLDKICLAV---KLLSPNTIISEYLGITISPPPLINVHHAVQFLKK 693
            ::|.:|...:.|.|.:..:.|:::||.:   .|.||    .::|...:.||.|..:.:|:..|:|
Human   995 TRERFEGFMDYSVPEILRVPLEELCLHIMKCNLGSP----EDFLSKALDPPQLQVISNAMNLLRK 1055

  Fly   694 IDVLD-DAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPF--TED 755
            |...: :...:|.||..|..:||:.::|:|||||.:..||||:.|:.:.::...|...|.  .::
Human  1056 IGACELNEPKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFTTPIGRKDE 1120

  Fly   756 IDNLWDRFTIYIQNSIKKERTYLSDNQFSDHFIFVRLYKEWQNRMH----------------NRT 804
            .|             :.|....::|   |||......|..|:....                |||
Human  1121 AD-------------LAKSALAMAD---SDHLTIYNAYLGWKKARQEGGYRSEITYCRRNFLNRT 1169

  Fly   805 PPLYLKDEYEFMLNGLMEQLTSIRSEIVSSLRAANLIHSRGKLSM-NNLNQMSCNWH---MVKAA 865
            ..|.|:|               ::.|::..::||....|....|. .|....:.::.   ::||.
Human  1170 SLLTLED---------------VKQELIKLVKAAGFSSSTTSTSWEGNRASQTLSFQEIALLKAV 1219

  Fly   866 LTGGMYPNIYAVDTRKS--------SLKSAFSGNVSMHPNTVLRDFLEPLNISAQSFRTPWIVCN 922
            |..|:|.|:..:...||        .:.....|...:||::|.||.        |:.  .|::
Human  1220 LVAGLYDNVGKIIYTKSVDVTEKLACIVETAQGKAQVHPSSVNRDL--------QTH--GWLL-- 1272

  Fly   923 RQKSHIVYA-------TLVVPLAVAMFSGHPRIRLSPICDSEMSLTDRNVNVFIDEWIW 974
             .:..|.||       ||:.|..|.:|.|          |.|:...:|.::  ||.||:
Human  1273 -YQEKIRYARVYLRETTLITPFPVLLFGG----------DIEVQHRERLLS--IDGWIY 1318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	3/31 (10%)
		ANK	407..>460	CDD:238125	3/52 (6%)
		Ank_2	413..>460	CDD:289560	3/46 (7%)
		HrpA	<484..973	CDD:224557	127/553 (23%)
		HA2	694..763	CDD:214852	21/71 (30%)
		OB_NTP_bind	823..945	CDD:285018	30/140 (21%)
DHX29	NP_061903.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..75
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..226
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..526		1/2 (50%)
		DEXDc	578..764	CDD:214692	46/185 (25%)
		DEXDc	589..736	CDD:238005	39/146 (27%)
		DEAH box. /evidence=ECO:0000255\|HAMAP-Rule:MF_03068	702..705		0/2 (0%)
		Helicase_C	847..985	CDD:278689	39/165 (24%)
		HA2	1056..1137	CDD:214852	26/96 (27%)
		OB_NTP_bind	1179..1302	CDD:285018	31/145 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810