DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and Dhx30

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	XP_006243888.1	Gene:	Dhx30 / 367172	RGDID:	1308888	Length:	1222	Species:	Rattus norvegicus

Alignment Length:	869	Identity:	193/869 - (22%)
Similarity:	321/869 - (36%)	Gaps:	256/869 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 DEILQSLYASRVIVYNAALCWDKSVFLPLVILD----DCRNKKSNVKIMCIERQAILATYNSQRT 215
            |.||.::....|:|.:......|:..:|.::|:    :.|..:.||.|  .:.:.|.|...:||.
  Rat   469 DTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVII--TQPRRISAVSVAQRV 531

  Fly   216 ANFFGEQLGETVGIQLPYFS-AVSSSTFIIYSTAQYFLRSLTSQ-QFRNISHLVVNDVHLHDPYT 278
            ::..|..|...||.|:...| ..:....:::.|....||.|.|. ....:||::|::||..|..|
  Rat   532 SHELGPSLRRNVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNT 596

  Fly   279 DILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFGEGLQLNMIKQPEVAPRVS--YLNELHSCI 341
            |.||..::.....:..||:||:|..|:.::|:.:||   ...:||.|.....|.  ||.::   :
  Rat   597 DFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFG---GCPVIKVPGFMYPVKEHYLEDI---L 655

  Fly   342 ALAGIHKGPDIYKEIPEAFRANNPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSL 406
            |..|.|:.|                                                   :||.
  Rat   656 AKLGKHQYP---------------------------------------------------HRHR- 668

  Fly   407 TGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVK 471
                  |..||                                    .||.
  Rat   669 ------HHESE------------------------------------DECA-------------- 677

  Fly   472 SAKPDFVDYDLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIV-------------KLNYMI 523
                  :|.||:.|::..:..:.|       ||.||..||.:..|.             :..|:|
  Rat   678 ------LDLDLVTDLVLHIDARGE-------PGGILCFLPGWQEIKGVQQRLQEALGMHESKYLI 729

  Fly   524 LS-HCLTGSLQECSIFLLYDNMRNDYLQALVNASDETVKVVLATDIIESLCLKVPFKYQIDTACR 587
            |. |.....:.:.:||          .|..:...    |:||||:|.|:........:.:|:...
  Rat   730 LPVHSNIPMMDQKAIF----------QQPPLGVR----KIVLATNIAETSITVNDIVHVVDSGLH 780

  Fly   588 LNNVYD---TTSCSGDDRFEWVAKDALLRRELILQPNKGDVQ---CFRLISKEAYEELSETSQPS 646
            ....||   ..||.   ...||::..:::|    :...|..|   .:.|..:...|::.....|.
  Rat   781 KEERYDLKTKVSCL---ETVWVSRANVIQR----RGRAGRCQSGFAYHLFPRSRLEKMVPFQVPE 838

  Fly   647 LQTMQLDKICLAVKLLSPNTIISEYLGITISPPPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLM 711
            :....|:.:.|..|:..|.....|:|...:..|.:..|..||..|::|.|||..|.:|.||.||.
  Rat   839 ILRTPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLA 903

  Fly   712 DIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKKERT 776
            .|....:|.:.::...:.|||.|:|.:||.| |.|    ||:..:.|         :..:.|.:.
  Rat   904 HISTDPRLAKAIVLAAIFRCLHPLLVVVSCL-TRD----PFSSSLQN---------RAEVDKVKA 954

  Fly   777 YLSDNQFSDHFIFVRLYKEWQN--RMHNRTP-PLYLKDEYEF-----MLNGLMEQLTSIRSEIVS 833
            .||.:..|||..|||....|:.  |..:||. ..||::...:     .::||::|.:       .
  Rat   955 LLSHDSGSDHLAFVRAVAGWEEVLRWQDRTSRENYLEENLLYAPSLRFIHGLIKQFS-------E 1012

  Fly   834 SLRAANLIHSRGKLSMNNLNQMSCNWH-----MVKAALTGGMYPNIYAVDTRKSSLKSAF----- 888
            ::..|.|:   ||.|...|....||.:     :||..|..|:|||:..|...|.:.:..|
  Rat  1013 NIYEAFLV---GKPSDCTLPSAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSV 1074

  Fly   889 -----SGNVSMHPNTVLRDFLEPLNISAQSFRTPWI-----VCNRQKSHIVYATLVVPLAVAMFS 943
                 |||:.:|.:|:.|:        |...|:.|:     |.:.....:..::.|.||||.:
  Rat  1075 TYRTKSGNILLHKSTINRE--------ATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAVLL-- 1129

  Fly   944 GHPRIRLSPICDSEMSLTDRNVNV 967
                            |||.:|::
  Rat  1130 ----------------LTDGDVHI 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	3/31 (10%)
		ANK	407..>460	CDD:238125	5/52 (10%)
		Ank_2	413..>460	CDD:289560	5/46 (11%)
		HrpA	<484..973	CDD:224557	127/532 (24%)
		HA2	694..763	CDD:214852	25/68 (37%)
		OB_NTP_bind	823..945	CDD:285018	34/141 (24%)
Dhx30	XP_006243888.1	DEXDc	466..645	CDD:214692	49/180 (27%)
		DEXDc	480..621	CDD:238005	39/142 (27%)
		HELICc	714..813	CDD:197757	22/119 (18%)
		HA2	885..968	CDD:214852	31/96 (32%)
		OB_NTP_bind	1008..1130	CDD:285018	34/157 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810