DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and Dhx15

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster

Alignment Length:	902	Identity:	153/902 - (16%)
Similarity:	306/902 - (33%)	Gaps:	297/902 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 LPAIRPPNLRFWTEAQLNFLTAFLGHSLSDEILQSLYASRVIV----YNAALCWDKSVFLPLVIL 186
            :|..:||.        :|.||    ::...:..|:||..|:.:    |.|.       |:.|:.|
  Fly    42 VPNKQPPT--------MNPLT----NTPYSQRYQNLYKKRIALPVFEYQAD-------FMRLLSL 87

  Fly   187 DDC----------------------RNKKSNVKIMCIERQAILATYNSQRTANFFGEQLGETVGI 229
            ..|                      ...|....:.|.:.:.:.|...:||.:.....:|||.||.
  Fly    88 HQCIVLVGETGSGKTTQIPQWCVDFAVSKGRKGVSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGY 152

  Fly   230 QLPYFSAVSSSTFIIYSTAQYFLRSLTS----QQFRNISHLVVNDVHLHDPYTDILLSEIRMALS 290
            .:.:....::.|.:.|.|....||...|    .|::.|   ::::.|.....||||:..::..:.
  Fly   153 SIRFEDCSTAKTLLKYMTDGMLLREAMSDPMLDQYQVI---LLDEAHERTLATDILMGVLKEVIR 214

  Fly   291 SHQNLRVVLLSQMGNPKKFTDFFGEGLQLNMIKQPEVAPRVSYLNELHSCIALAGIHKGPDIYKE 355
            ...:|::|::|...:..||..:|            :.||.:......|..
  Fly   215 QRSDLKLVVMSATLDAGKFQQYF------------DNAPLMKVPGRTHPV--------------- 252

  Fly   356 IPEAFRANNPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNK 420
              |.|....|..:.:            :||:|..:                    .:|...|:..
  Fly   253 --EIFYTPEPERDYL------------EAAIRTVI--------------------QIHMCEEIEG 283

  Fly   421 ANHLRLLLFMGADPYIVDL---FQQNAISLAAMNGNHECIDVLNSY--SLHGYVVKSAKPDFVDY 480
                .:|:|:.....|.:.   .::...:|.:..|..:||.:.::.  :|...:.:.|.|...:
  Fly   284 ----DILMFLTGQEEIEEACKRIKREIDNLGSEIGELKCIPLYSTLPPNLQQRIFEPAPPPNAN- 343

  Fly   481 DLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHCLTGSLQECSIFLLYDNMR 545
                                                             |::..
  Fly   344 -------------------------------------------------GAIGR----------- 348

  Fly   546 NDYLQALVNASDETVKVVLATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDA 610
                           |||::|:|.|:........:.||.......||:..
  Fly   349 ---------------KVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPR--------------- 383

  Fly   611 LLRRE-LILQP-NKGDVQ-------------CFRLISKEAYE-ELSETSQPSLQTMQLDKICLAV 659
             :|.| |::.| :|...|             ||||.:::|:: |:.:.:.|.:....|..:.|.:
  Fly   384 -IRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQL 447

  Fly   660 KLLSPNTIIS-EYLGITISPPPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRML 723
            |.|..:.::. :::    .||....:..|::.|..:..|||..::|.||..:.:.|:..||.:||
  Fly   448 KKLGIDDLVHFDFM----DPPAPETLMRALELLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKML 508

  Fly   724 IFGILLRCLDPILTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKKERTYLSDNQFS---- 784
            |......|.:.||:|.:.||      :|            ..:::.:..|:....:..:|:
  Fly   509 IASCQHNCSNEILSITAMLS------VP------------QCFVRPNEAKKAADEAKMRFAHIDG 555

  Fly   785 DHFIFVRLYKEWQNRMHNRTPPLYLKDEYEFMLN-GLMEQLTSIRSEIVSSLRAANLIHSRGKLS 848
            ||...:.:|..::....:   |.:.   ||..:| ..::...::|.::..       |..|..|.
  Fly   556 DHLTLLNVYHAFKQSSED---PNWC---YENFINFRSLKSADNVRQQLAR-------IMDRFNLR 607

  Fly   849 MNNLNQMSCNWHM-VKAALTGGMYPNIYAVDTRKSSLKSAFSGNVSMHPNTVLRDFLEPLNISAQ 912
            ..:....|.:::: ::.||..|.:..:..::.....|....:.||.:||:|.|
  Fly   608 RTSTEFTSKDYYVNIRKALVQGFFMQVAHLERTGYYLTIKDNQNVQLHPSTCL------------ 660

  Fly   913 SFRTPWIVCNR----QKSHIVYATLVVP-----LAVAMFSGHPRIRLSPICDSEMSL 960
            ..:..|::.|.    .|::|...|.|.|     ||...:.    :...|.|:::..|
  Fly   661 DHKPDWVIYNEFVLTTKNYIRTVTDVKPEWLCCLAPQYYD----LNNFPQCEAKRQL 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	5/31 (16%)
		ANK	407..>460	CDD:238125	9/55 (16%)
		Ank_2	413..>460	CDD:289560	9/49 (18%)
		HrpA	<484..973	CDD:224557	87/509 (17%)
		HA2	694..763	CDD:214852	19/68 (28%)
		OB_NTP_bind	823..945	CDD:285018	24/131 (18%)
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	13/62 (21%)
		DEXDc	67..255	CDD:214692	40/226 (18%)
		DEXDc	91..228	CDD:238005	26/139 (19%)
		HELICc	315..408	CDD:197757	22/184 (12%)
		HA2	478..561	CDD:214852	23/100 (23%)
		OB_NTP_bind	595..698	CDD:285018	23/121 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810