DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and mle

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster

Alignment Length:	1112	Identity:	229/1112 - (20%)
Similarity:	383/1112 - (34%)	Gaps:	336/1112 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NHIIQD-KYI---PQQLLYFLAGRRCCQQFPCTFRTSEHEAFANNARS------LGLRSQVVHVN 56
            |:|..| ||.   |:....|||  ......|...||.......:|.:|      |.|..|:.|:|
  Fly   181 NNIRDDYKYTPVGPEHARSFLA--ELSIYVPALNRTVTARESGSNKKSASKSCALSLVRQLFHLN 243

  Fly    57 GNSCVKVYKQACRHYLEEPKTLVLSSGATLNMFTLLSRKSLMGKEDLELYADLVSMK-ANASDLP 120
                           :.||     .||      ||..:|.    |.|:.|...:|.. .|..|..
  Fly   244 ---------------VIEP-----FSG------TLKKKKD----EQLKPYPVKLSPNLINKIDEV 278

  Fly   121 SLHLPLPAIRPPNLRF---------------------------------WTEAQLNF-------- 144
            ...|.||.:.|.|::.                                 |...|.|:
  Fly   279 IKGLDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNI 343

  Fly   145 ------------LTAFLGHSLSD-------------------------EILQSLYASRVIVYNAA 172
                        |:.....||.|                         |||.::..:.|::....
  Fly   344 DEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGN 408

  Fly   173 LCWDKSVFLPLVILDD--CRNKKSNVKIMCIERQAILATYNSQRTANFFGEQLGETVGIQLPYFS 235
            ....|:..:...||||  |..:.....|...:.:.|.|...::|.|....||||:|||     :|
  Fly   409 TGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVG-----YS 468

  Fly   236 AVSSSTF------IIYSTAQYFLRSLTSQQFRNISHLVVNDVHLHDPYTDILLSEIRMALSSHQN 294
            ....|.|      |::.|....||.|.: ..|.:||::|:::|..|..:|.||..:|..:.::.:
  Fly   469 VRFESVFPRPYGAILFCTVGVLLRKLEA-GLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPD 532

  Fly   295 LRVVLLSQMGNPKKFTDFFGEGLQLNMIKQPEVAPRVSYLNELHSCIALAGIHKGPDIYKEIPEA 359
            |.|:|:|...:..||:.:||      :....||..|...:.:..    |..|.:..|.   :|.|
  Fly   533 LHVILMSATIDTTKFSKYFG------ICPVLEVPGRAFPVQQFF----LEDIIQMTDF---VPSA 584

  Fly   360 FRANNPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNKANHL 424
             .:...|.|..|:               ..|.:.:.|.|.:||                ||.
  Fly   585 -ESRRKRKEVEDE---------------EQLLSEDKDEAEINY----------------NKV--- 614

  Fly   425 RLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYL 489
                       ..|.:.|...:..||....:                      |.::|:..::..
  Fly   615 -----------CEDKYSQKTRNAMAMLSESD----------------------VSFELLEALLMH 646

  Fly   490 LRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHCLTGSLQECSIFLLYDNMRNDYLQALVN 554
            :::|       ..||.||:.||.:..|..|...:.:..:.|...:..|...:..:..|..:.:..
  Fly   647 IKSK-------NIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFE 704

  Fly   555 ASDETV-KVVLATDIIESLCLKVPFKYQIDTACRL--------NNV--YDTTSCSGDDRFEWVAK 608
            ...|.| |::|:|:|.|:........:.|| .|:.        ||:  |.|.         |.:|
  Fly   705 PVPEGVTKIILSTNIAETSITIDDIVFVID-ICKARMKLFTSHNNLTSYATV---------WASK 759

  Fly   609 DALLRRELILQPNKGDVQ---CFRLISKEAYEELSETSQPSLQTMQLDKICLAVKLLSPNTIISE 670
            ..|.:|    :...|.|:   ||.|.|:..::.|.:...|.:....|.::.|.:|||...: |..
  Fly   760 TNLEQR----KGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGS-IHH 819

  Fly   671 YLGITISPPPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPI 735
            :|...:.|||:..|..|...|:::..||..:::|.||..|..:|:..:||:|::.|.:..|.|.:
  Fly   820 FLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLM 884

  Fly   736 LTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKKERTYLSDNQFSDHFIFVRLYKEWQNRM 800
            ..:.|..||...:   |:.||.          |..:...:..||..:.|||...:...:.|:..
  Fly   885 AIMASYSSTFSEV---FSLDIG----------QRRLANHQKALSGTKCSDHVAMIVASQMWRRE- 935

  Fly   801 HNRTPPLYLKDEYEFM------LNGL----MEQLTSIRSEIVSSLRAANLIHSRGKLSMNNLNQM 855
                     |...|.|      ..||    |..:...:.:::..|:.|..             ..
  Fly   936 ---------KQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGF-------------PE 978

  Fly   856 SCN-WHMVKAALTG--------------GMYPNIYAVDTRKSSL----KSAFSGNVSMHPNTVLR 901
            .|. .|.|...:.|              |:||||.....::..|    |:|.....|::.:.:..
  Fly   979 ECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTTESKAALLHKTSVNCSNLAV 1043

  Fly   902 DFLEPLNISAQSFRTPWIVCNRQKSHIVYATLVVPLAVAMFSGHPRIRLSPICDSEMSLTDRNVN 966
            .|..|..:..:..||..:.|.:       .::|.||.|.:|...           ::.|...|:
  Fly  1044 TFPYPFFVFGEKIRTRAVSCKQ-------LSMVSPLQVILFGSR-----------KIDLAANNI- 1089

  Fly   967 VFIDEWI 973
            |.:|.|:
  Fly  1090 VRVDNWL 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	2/31 (6%)
		ANK	407..>460	CDD:238125	6/52 (12%)
		Ank_2	413..>460	CDD:289560	6/46 (13%)
		HrpA	<484..973	CDD:224557	112/531 (21%)
		HA2	694..763	CDD:214852	19/68 (28%)
		OB_NTP_bind	823..945	CDD:285018	25/140 (18%)
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634	17/60 (28%)
		DEXDc	393..569	CDD:214692	50/187 (27%)
		DEXDc	402..542	CDD:238005	41/145 (28%)
		ATP-synt_B	<584..644	CDD:304375	17/127 (13%)
		Helicase_C	643..772	CDD:278689	31/149 (21%)
		HA2	842..926	CDD:214852	25/96 (26%)
		OB_NTP_bind	974..1078	CDD:285018	23/123 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810