DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and dhx16

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_956318.1	Gene:	dhx16 / 336645	ZFINID:	ZDB-GENE-030131-8589	Length:	1054	Species:	Danio rerio

Alignment Length:	886	Identity:	163/886 - (18%)
Similarity:	303/886 - (34%)	Gaps:	298/886 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 VKVYKQACRHYLEEPKTLVLSSGATLNMFTLLSRKSLMGKEDLELYADLVSMKANASDLPSLHLP 125
            :|..::..:..|||.:.:...|       |.::.|..:.:::.|  .:|...:.....:..:...
Zfish   356 IKEEQERYQLILEEEEMITFVS-------TAITMKGTLSEKESE--PELSQAEKQKQSIQEVRRS 411

  Fly   126 LPAIRPPNLRFWTEAQLNFLTAFLGHSLSDEILQSLYASRVIVYNAALCWDKSVFLPLVILDDCR 190
            || |.|                     ..:::|.::...:::|........|:..:|..:|:: .
Zfish   412 LP-IFP---------------------YREDLLAAIGDHQILVIEGETGSGKTTQIPQYLLEE-G 453

  Fly   191 NKKSNVKIMCIERQAILATYNSQRTANFFGEQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLRS- 254
            ..|..:||.|.:.:.:.|...:.|.|.....:||..||..:.:....|..|.:.|.|....||.
Zfish   454 YTKGGMKIGCTQPRRVAAMSVAARVAQEMSVKLGNEVGYSIRFEDCTSERTILKYMTDGMLLREF 518

  Fly   255 LTSQQFRNISHLVVNDVHLHDPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFGEGLQL 319
            ||.....:.|.:::::.|....:||||...|:.......:|:|::.|...:.::|:.||
Zfish   519 LTEPDLASYSVIIIDEAHERTLHTDILFGLIKDIARFRPDLKVLVASATLDTERFSSFF------ 577

  Fly   320 NMIKQPEVAPRVSYLNELHSCIALAGIHKGPDIYKEIPEAFRANNPRNEQMDKCLQAYGELGTDA 384

Zfish   578 ----------------------------------------------------------------- 577

  Fly   385 ALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAA 449
                       |.||| :|
Zfish   578 -----------DDAPV-FR---------------------------------------------- 584

  Fly   450 MNGNHECIDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYY 514
            :.|....:|:        |..|:.:.|::: ..::.::.:..|:        |||::|:.|....
Zfish   585 IPGRRFPVDI--------YYTKAPEADYLE-ACVVSVLQIHVTQ--------SPGDVLVFLTGQE 632

  Fly   515 HIVKLNYMILSHC--LTGSLQECSIFLLYDNMRNDYLQALVNASDETV-KVVLATDIIESLCLKV 576
            .|.....::...|  |...:.|..:..:|.|:.:|....:.|.:.... |||:||:|.|:.....
Zfish   633 EIEACCELLQERCRRLGSKISELLVLPIYANLPSDMQAKIFNPTPPGARKVVVATNIAETSLTID 697

  Fly   577 PFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLRRELILQP-----------NKGDV---QC 627
            ...|.||........|:             ||..:  ..||:.|           ..|.|   :|
Zfish   698 GIIYVIDPGFCKQKSYN-------------AKTGM--ESLIVTPCSRASANQRAGRAGRVAAGKC 747

  Fly   628 FRLISKEAYE-ELSETSQPSLQTMQLDKICLAVKLLSPNTIIS-EYLGITISPPPLINVHHAVQF 690
            |||.:..|:: |:.||:.|.:|...|..:.|.:|.|..|.:|. :::    .|||...:..|::.
Zfish   748 FRLYTAWAFKHEMEETTVPEIQRTNLGNVVLLLKSLGINDLIHFDFM----DPPPHETLVLALEQ 808

  Fly   691 LKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPFTED 755
            |..:..|:...::|.||.|:.::||...|.:|::.....:|.:.:|||.:.||
Zfish   809 LYALGALNHLGELTKLGRRMAELPVDPMLSKMILASEQYKCSEEVLTIAAMLS------------ 861

  Fly   756 IDNLWDRFTIYIQNSI---KKERTYLSDN---QF----SDHFIFVRLYKEW-------------- 796
                       :.|||   .|::...:||   .|    .||.:.:.:|.:|
Zfish   862 -----------VNNSIFYRPKDKVVHADNARMNFVVPGGDHLVLLNVYTQWVESGYSTQWCFENF 915

  Fly   797 -QNRMHNRTPPLYLKDEYEFMLNGLMEQLTSIRSEIVSSLRAANLIHSRGKLSMNNLNQMSCNWH 860
             |.|...|...  ::|:    |.|||::   |..|:.||                |.:.|.
Zfish   916 IQFRSMKRARD--VRDQ----LEGLMDR---IEVELCSS----------------NGDSMP---- 951

  Fly   861 MVKAALTGGMYPNIYAVDTRKSSLKSA-FSGNVSMHPNTVL 900
             ::.|:|.|.:  .:.....|...|:. ....|.:|||:.|
Zfish   952 -IRKAVTAGYF--YHTARLSKGGYKTVKHQQTVYVHPNSSL 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	0/31 (0%)
		ANK	407..>460	CDD:238125	2/52 (4%)
		Ank_2	413..>460	CDD:289560	2/46 (4%)
		HrpA	<484..973	CDD:224557	103/462 (22%)
		HA2	694..763	CDD:214852	15/68 (22%)
		OB_NTP_bind	823..945	CDD:285018	16/79 (20%)
dhx16	NP_956318.1	BLVR	<94..>142	CDD:283923
		GBP_C	<177..296	CDD:303769
		coiled coil	271..285	CDD:293879
		DEXDc	407..594	CDD:214692	47/338 (14%)
		DEXDc	429..568	CDD:238005	33/139 (24%)
		Helicase_C	612..742	CDD:278689	31/152 (20%)
		HA2	811..895	CDD:214852	24/106 (23%)
		OB_NTP_bind	916..1028	CDD:285018	24/106 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900