DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and CG1582

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster

Alignment Length:	936	Identity:	208/936 - (22%)
Similarity:	380/936 - (40%)	Gaps:	190/936 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 DEILQSLYASRVIVYNAALCWDKSVFLPLVILDD---------CRNKKSNVKIMCIERQAILATY 210
            :.||..:.:|.|:|.:......||..:|..|||:         .:....:|:|:|.:.:.:.|..
  Fly   460 ERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIG 524

  Fly   211 NSQRTANFFGEQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLRSLTSQQ-FRNISHLVVNDVHLH 274
            .::|.|....:::|:.||.|:...:.||.||.:.:.|....||.|.|.. ..:::|::|::||..
  Fly   525 VAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHER 589

  Fly   275 DPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFGEGLQLNMIKQPEVAPRVSYLNELHS 339
            ...:|.||..::..|...::|:|:|:|...|...|:|:||....|      ::..|...:.:|.
  Fly   590 SEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVL------DIPGRTFPVQQLF- 647

  Fly   340 CIALAGIHKGPDIYKEIPEAFRANNPRNEQ--MDKCL-----QAYGELGTDAALRPFLYAVNYDL 397
               |..|.:..|...|....:.....:.||  :::.|     ||.||
  Fly   648 ---LEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASGE------------------ 691

  Fly   398 APVNYRHSLTGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNS 462
            ||        ||          |....:|.|        .:.:|:.|                 .
  Fly   692 AP--------GK----------KIKDEKLTL--------AETYQRYA-----------------E 713

  Fly   463 YSLHGYVVKS---AKPDFVDYDLIIDIM-YLLRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMI 523
            ||..  ..||   .:|..::.:||..:: |::....:: |.|   |.|||.||.:..|..::..:
  Fly   714 YSKP--TCKSIYLMEPMTINPELIESVLKYIVEGSHDW-PRE---GTILIFLPGFGEIQSVHDSL 772

  Fly   524 LSHCLTGSLQECSIFLLYDNMRNDYLQALV--NASDETVKVVLATDIIESLCLKVPFKYQIDTAC 586
            |.:.|........|.:...:..:...||||  .|.....|:||:|:|.|:........:.:|...
  Fly   773 LDNALFSPRAGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGL 837

  Fly   587 RLNNVYDTTSCSGDDRFEWVAKDALLRRELILQPNKGDVQ---CFRLISKEAYE-ELSETSQPSL 647
            .....:|:..........||::....:|    :...|.|.   |..|.:...|: .:.....|.:
  Fly   838 MKEKCFDSNRNMESLDLVWVSRANAKQR----KGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEI 898

  Fly   648 QTMQLDKICLAVKLL----SPNTIISEYLGITISPPPLINVHHAVQFLKKIDVLDDAEDVTWLGC 708
            |.:.|::|.|.:|.|    |.||:  ..|..|:..|...:|..|:..|:.:..||..:.:|.||.
  Fly   899 QRVPLEQIVLRIKTLQTFASRNTL--SVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGH 961

  Fly   709 RLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKK 773
            .|..:||..::|:::::|.:.:|||.:|||.:.||...|...|..:..:            :.|.
  Fly   962 HLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTE------------ADKC 1014

  Fly   774 ERTYLSDNQFSDHFIFVRLYKEWQN--RMHNRTPPLYLKDEYEFMLNGLMEQLTSIRSEIVSSLR 836
            :|.:...|  |||...:..|::|.:  |..|.........|:...||.| |.:..::.:.:..|.
  Fly  1015 KRMFALGN--SDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNTL-ETIADLKYQYLELLV 1076

  Fly   837 AANL----IHSRGKLSMNNL--------NQMSCNWHMVKAALTGGMYPNIYAVDT---------- 879
            :...    :..|.|.:.:|:        |....|..::.:.|...:||||..:.|
  Fly  1077 SIGFVPIDVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAG 1141

  Fly   880 ----RKSS-----LKSAFSGNVSMHPNTVLRDFLEPLNISAQSFRTPWIVCNRQ-KSHIVY---A 931
                |:.|     .|:...|.|.:||::|        |.....|:.|::|...: ::..:|   .
  Fly  1142 GAVPREPSHHDLRFKTRGDGYVKIHPSSV--------NSQVSVFQAPFLVFQEKVRTSAIYIRDC 1198

  Fly   932 TLVVPLAVAMFSGHPRIRLSPICDSEMSLTDRNVNVFIDEWIWMVMSKA----TAEMVMRTRYYF 992
            :::..:|:.:|:|         .|.::.|.|.:. :|:.|..|::: ||    |||||...|...
  Fly  1199 SMLPLIAMVLFAG---------SDFKVELHDGDF-LFLLESGWIIL-KAHDLETAEMVQCLRAEM 1252

  Fly   993 FKMYHDLLKH-CSELDMWRRDCEPVS 1017
            .|:..:.::. |..|...:..|..::
  Fly  1253 IKLLEEKIRDPCLNLLHHKNGCRMIA 1278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	5/31 (16%)
		ANK	407..>460	CDD:238125	7/52 (13%)
		Ank_2	413..>460	CDD:289560	5/46 (11%)
		HrpA	<484..973	CDD:224557	118/536 (22%)
		HA2	694..763	CDD:214852	20/68 (29%)
		OB_NTP_bind	823..945	CDD:285018	27/156 (17%)
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	187/851 (22%)
		DEXDc	471..619	CDD:238005	39/147 (27%)
		HELICc	781..871	CDD:197757	17/93 (18%)
		HA2	948..1029	CDD:214852	26/94 (28%)
		OB_NTP_bind	1070..1212	CDD:285018	28/158 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810