DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and Dhx36

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_001101148.1	Gene:	Dhx36 / 310461	RGDID:	1308767	Length:	1000	Species:	Rattus norvegicus

Alignment Length:	1029	Identity:	246/1029 - (23%)
Similarity:	411/1029 - (39%)	Gaps:	207/1029 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 NSCVKVYKQACRHYLEEPKTLVLSSGATLNM---FTLLSRKSLMGKEDLELYADLVSMKANASDL 119
            ||..|:..|..:...:|.||..::..:.::.   :.|...:..:|. |.:|..||...|.:..
  Rat   127 NSEKKLDNQEKKLLNQEKKTYRITDKSYIDRDSEYLLQQNEPNLGL-DQQLLEDLQKKKTDPR-- 188

  Fly   120 PSLHLPLPAIRPPNLRFWTEAQLNFLTAFLGHSLSDEILQSLYASRVIVYNAALCWDKSVFLPLV 184
                             :.|.| .|......:.:..|::..:...:|.|.:......|:..:...
  Rat   189 -----------------YIEMQ-RFRKKLPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQF 235

  Fly   185 ILDDC--RNKKSNVKIMCIERQAILATYNSQRTANFFGEQL--GETVGIQLPYFSAV-SSSTFII 244
            |||:.  |...|..:|:|.:.:.|.|...::|.|....|..  |.:.|.|:...|.: .....|:
  Rat   236 ILDNYIERGIGSACRIVCTQPRRISAISVAERVAAERAESCGNGNSTGYQIRLQSRLPRKQGSIL 300

  Fly   245 YSTAQYFLRSLTS-QQFRNISHLVVNDVHLHDPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKK 308
            |.|....|:.|.| .:..::||:|::::|..:..:|:|::.|:..|....:|:|:|:|...|.:|
  Rat   301 YCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEK 365

  Fly   309 FTDFFGEGLQLNMIKQPEVA-PRVSYLNELHSCIALAGIHKGPDIYKEIPEAFRANNPRNEQMDK 372
            |:::||   ...||..|... |.|.||.|              ||.::|.........|::....
  Rat   366 FSEYFG---NCPMIHIPGFTFPVVEYLLE--------------DIIEKIRYFPEQKEHRSQFKRG 413

  Fly   373 CLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNKANHLRLLLFMGADPYIV 437
            .:|.:                      || |.....|.|::  .|...|             ||.
  Rat   414 FMQGH----------------------VN-RQEKEEKEAIY--KERWPA-------------YIK 440

  Fly   438 DLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRTKPEYSPGEYS 502
            :|..:.:.|         .||||          :....|.||.:||..::       .|...|..
  Rat   441 ELQTRYSAS---------TIDVL----------EMMDDDKVDLNLIAALI-------RYIVLEEE 479

  Fly   503 PGNILIILPTYYHIVKLNYMILSHCLTGSLQECSIFLLYDNMRNDYLQALVNASDETV------- 560
            .|.||:.||.:.:|..|:.:::|..:..|    ..||:..      |.:|:...::|.
  Rat   480 DGAILVFLPGWDNISTLHDLLMSQVMFKS----DRFLIIP------LHSLMPTVNQTQVFKKTPP 534

  Fly   561 ---KVVLATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLRRELILQPNK 622
               |:|:||:|.|:........|.||........:||.:.......|||:|....:|    :...
  Rat   535 GVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQR----KGRA 595

  Fly   623 GDVQ---CFRLISKEAYEELSETSQPSLQTMQLDKICLAVKLLSPNTIISEYLGITISPPPLINV 684
            |.||   |:.|.:......|.:...|.:....|:::||.:|:|.... |:.:|...:.||....|
  Rat   596 GRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQIKILRLGG-IAYFLSRLMDPPSDEAV 659

  Fly   685 HHAVQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLG 749
            ..:::.|.::..||..|::|.||..|..:||...:|:|::||.|..||||:|||.:|||..||..
  Rat   660 VLSIKHLMELSALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFV 724

  Fly   750 IPFTEDIDNLWDRFTIYIQNSIKKERTYLSDNQFSDHFIFVRLYKEWQNRMHNRTPPLYLKD--- 811
            ||..::          .|.::.:||   |:....|||...|..::.|:..  .|....|.||
  Rat   725 IPLGKE----------KIADARRKE---LAKETRSDHLTVVNAFEGWEEA--KRRGFRYEKDYCW 774

  Fly   812 EYEFMLNGLMEQLTSIRSEIVSSLRAANLIHSRG-KLSMNNLNQMSCNWHMVKAALTGGMYPNIY 875
            || |:.:..::.|.:::.:....|..|..:.||. |....|:|  |.|..::||.:..|:||.:.
  Rat   775 EY-FLSSNTLQMLHNMKGQFAEHLLGAGFVSSRSPKDPKANIN--SDNEKIIKAVICAGLYPKVA 836

  Fly   876 AV-----DTRKS-SLKSAFSGNVSMHPNTVLRDFLEPLNISAQSFRTPWIVCN---RQKSHIVY- 930
            .:     ..||. .:.:...|.||:||.:|        |:....|...|::.:   |..|..:|
  Rat   837 KIRLNLGKKRKMVKVHTKSDGLVSIHPKSV--------NVEQTDFHYNWLIYHLKMRTSSIYLYD 893

  Fly   931 ATLVVPLAVAMFSGHPRIRLSPICDSEMSLTDRNVNVFIDEWIWMVMSKATAEMVMRTRYYFFKM 995
            .|.|.|..:..|.|.  |.:....|.|:        :.:||||.....:..|.:|...|    |.
  Rat   894 CTEVSPYCLLFFGGD--ISIQKDKDQEI--------IAVDEWIVFQSPERIAHLVKGLR----KE 944

  Fly   996 YHDLLK---HCSELDMWR----RDCEPVSQYTVLTDTLSKIF------ESEDGF 1036
            ...||:   .|.....|.    |||..:|....|..|..|..      .|:||:
  Rat   945 LDILLQEKIECPHPVDWNDTKSRDCAVLSAILDLIKTQEKAIPRNLPPRSQDGY 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	6/31 (19%)
		ANK	407..>460	CDD:238125	10/52 (19%)
		Ank_2	413..>460	CDD:289560	8/46 (17%)
		HrpA	<484..973	CDD:224557	133/515 (26%)
		HA2	694..763	CDD:214852	28/68 (41%)
		OB_NTP_bind	823..945	CDD:285018	33/132 (25%)
Dhx36	NP_001101148.1	HrpA	187..893	CDD:224557	201/847 (24%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	257..309		12/51 (24%)
		DEAH box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	326..329		0/2 (0%)
		RecA-like domain 2. /evidence=ECO:0000250\|UniProtKB:Q05B79	379..620		69/332 (21%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	490..549		15/68 (22%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	509..520		3/16 (19%)
		WH domain. /evidence=ECO:0000250\|UniProtKB:Q05B79	621..690		19/69 (28%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	630..689		17/59 (29%)
		OB-fold-like subdomains. /evidence=ECO:0000250\|UniProtKB:Q05B79	833..897		16/71 (23%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	841..852		2/10 (20%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	862..892		8/37 (22%)
		Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	1..192		14/84 (17%)
		Required for the pre-miR-134 transport. /evidence=ECO:0000269\|PubMed:23651854	1..96
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	1..43
		Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	45..97
		DSM (DHX36-specific motif). /evidence=ECO:0000250\|UniProtKB:Q05B79, ECO:0000250\|UniProtKB:Q9H2U1	45..67
		RecA-like domain 1. /evidence=ECO:0000250\|UniProtKB:Q05B79	98..378		62/274 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810