Protein Alignment bgcn and Ythdc2

DIOPT Version :10

• Sequence 1: NP_523832.2
• Gene: bgcn / 47873
• FlyBaseID: FBgn0004581
• Length: 1215
• Species: Drosophila melanogaster
• Sequence 2: NP_001414131.1
• Gene: Ythdc2 / 307446
• RGDID: 1563192
• Length: 1434
• Species: Rattus norvegicus
• Alignment Length: 1226
• Identity: 301/1226 - (24%)
• Similarity: 503/1226 - (41%)
• Gaps: 243/1226 - (19%)

  Fly    26 QFPCTFRTSEHEAFANNARSLGLRSQVVHVNGNSCVKVYKQ--------------------ACRH 70
            :||.:..::|.......::||||.|:......|..:.|.|:                    |.|.
  Rat    69 EFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKKDGSETAHAMMTCNLTHNTKHAVRS 133

  Fly    71 YLE------EPKTLVLSSGATLNMFTLLSRKSLMGKEDLELYADL--VSMKANASDLPSLHLPLP 127
            .::      :.:|.:|......|:|.:.:....|.|....|...:  |.:|...|:..|....||
  Rat   134 LIQRFPVTNKERTELLPKTERGNVFAVEAENREMSKTSGRLNNGIPQVPVKRGESEFDSFRQSLP 198

  Fly   128 AIRPPNLRFWTEAQLNFLTAFLGHSLSDEILQSLYASRVIVYNAALCWDKSVFLPLVILDDCRNK 192
            ..         |.|             :||::.:..::|::........|:..:|..:||||...
  Rat   199 VF---------EKQ-------------EEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKN 241

  Fly   193 KSNVKIMCIERQAILATYNSQRTANFFGEQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLRSLTS 257
            ....:|.|.:.:.:.|...::|.|....|::|:|:|.|:...|.||..|.:.:.|....||:|.:
  Rat   242 GIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMA 306

  Fly   258 --QQFRNISHLVVNDVHLHDPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFG------ 314
              .....::|::|::||..|.::|.||:::|..|..|..|:::|.|...:...|..:||
  Rat   307 GDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIY 371

  Fly   315 -------------------------EGLQLNMIKQPEVAPRVSYLNELHSC------------IA 342
                                     |.|:....||.|...:.: |.|.:|.            .|
  Rat   372 IQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREEKQQTT-LTEWYSAQENTFKPESQRQRA 435

  Fly   343 LAGIHKGPDIYKEIPEAFRANNPRNE----------QMDKCL-QAYGELGTDAALRPFLYAVNYD 396
            :|.:.:..|:..:..:|..:.....:          :||.|| ..:.....||..:.| :.:..:
  Rat   436 VASVSEEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDVDAFAQVF-HLILTE 499

  Fly   397 LAPVNYRHSLTGKTAVHFASELNKANHLRLLLFMGADPY--------------------IVDLFQ 441
            ...|:||||.|..||:..|:.....:.:..|:.|||:.:                    ||||.:
  Rat   500 NVSVDYRHSETSATALMVAAGRGFTSQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLE 564

  Fly   442 Q----------NAISLAAMNGNH---ECIDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRTK 493
            .          :..||...|||.   |..::|.:|. |.:     ..:.||.|||:.::|.:...
  Rat   565 SYSASLEFGNLDESSLVQTNGNDLSAEDRELLKAYH-HSF-----DDEKVDLDLIMHLLYNICHS 623

  Fly   494 PEYSPGEYSPGNILIILPTYYHIVKLNYMIL--SHCLTGSLQECSIFLLYDNMR-NDYLQALVNA 555
            .:       .|.|||.||.|..||.|...||  ......:.....:|:|:.||: :|..:.|.|.
  Rat   624 CD-------AGAILIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNP 681

  Fly   556 SDETVKVVLATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLRRELILQP 620
            .....|::|:|:|.|:........:.||:.......:|..:.....:..|::|.:.::|
  Rat   682 PAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQR------ 740

  Fly   621 NKGDVQ------CFRLISKEAYEELSETSQPSLQTMQLDKICLAVKLLSP-NTIISEYLGITISP 678
             ||...      ||||.|:..::.:.|...|.|..|.|.::||..|||:| |..|:::|.....|
  Rat   741 -KGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHTKLLAPVNCTIADFLMKAPEP 804

  Fly   679 PPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLS 743
            ||.:.|.:|||.||.||.:|..||:|.||..|.|:||...||:|::..::|:||||||||..:|:
  Rat   805 PPALIVRNAVQMLKTIDAMDAWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLA 869

  Fly   744 TADPLGIPFTEDIDNLWDRFTIYIQNSIKKE----RTYLSDNQFSDHFIFVRLYKEWQNRMHNRT 804
            ..||..:|               .|.|.|:.    |...:...||||...:|.::.||....:..
  Rat   870 YRDPFVLP---------------TQASQKRAAMLCRKRFTAGTFSDHMALLRAFQAWQKARSDGW 919

  Fly   805 PPLYLKDEYEFMLNGLMEQLTSIRSEIVSSLRAANLIHSRGKLSMNNLNQMSCNWHMVKAALTGG 869
            ...:.  |..|:....||.:..:|::::..|||:..:.:||...:.::|..|.||.:|||||..|
  Rat   920 ERAFC--EKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAG 982

  Fly   870 MYPNIYAVDTRKSSLKSAFSGNVSMHPNTVLRD----FLEPLNISA---QSFRTPWIVCNRQ-KS 926
            ||||:..||.....|.......|..||.:||..    .:.|.|..|   |:..|.|::.:.. ::
  Rat   983 MYPNLVHVDRENVVLTGPKEKKVRFHPTSVLSQPQYKKIPPANGQAAAIQALPTDWLIYDEMTRA 1047

  Fly   927 H----IVYATLVVPLAVAMFSGHPRIRLSPI---------------CDSEM-SLTDRNVNVF-ID 970
            |    |...:.|.|:.|.:|.|..|:..:.:               .|||| ..|..|:... :|
  Rat  1048 HRIANIRCCSAVTPVTVLVFCGPARLTSNALQEPSSFRADGIPNDSSDSEMEDRTTANLAALKLD 1112

  Fly   971 EWIWMVMSKATAEMVMRTRYYFFKMYHDLLKHCSELDMWRRDCEPVSQYTVLT-DTLSKIFESED 1034
            ||:...:....|.::::.|    :.:|.|.     |...|...:|.||....| ..:..:..:|:
  Rat  1113 EWLNFKLEPEAASLLLQLR----QKWHSLF-----LRRMRAPSKPWSQVDEATIRAIIAVLSTEE 1168

  Fly  1035 GFVGFFKPPPITFLPTP----QLP--------SLYLLSVNAHFSWAREVEENMLSK 1078
            ...|..:|..|...|.|    :||        :....|.:..||......|.:|.|
  Rat  1169 QSAGLQQPSGIGQRPRPMSSEELPLASSWRSNNSRKSSADTEFSDGSTAAERVLMK 1224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	DEAD-like_helicase_N	155..314	CDD:475120	42/160 (26%)
		ANKYR	<398..>460	CDD:440430	23/94 (24%)
		ANK repeat	406..438	CDD:293786	9/51 (18%)
		P-loop containing Nucleoside Triphosphate Hydrolases	465..>594	CDD:476819	33/131 (25%)
		HA2	687..789	CDD:461295	41/105 (39%)
		OB_NTP_bind	862..945	CDD:400182	30/94 (32%)
Ythdc2	NP_001414131.1	None