DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and Dhx37

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_001099396.2	Gene:	Dhx37 / 288647	RGDID:	1306837	Length:	1150	Species:	Rattus norvegicus

Alignment Length:	878	Identity:	155/878 - (17%)
Similarity:	313/878 - (35%)	Gaps:	233/878 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 PSLHLP---LPAIRPPNLRFWTEAQLNFLTAFLGHSLSDE--ILQSLYASRVIVYNAALCWDKSV 179
            |:|..|   :|..|.|.::   |.:|..      ..|::|  |::::....:::........|:.
  Rat   224 PALAKPAVFIPVNRTPEMQ---EERLKL------PILAEEQAIMEAVAEHPIVIVCGETGSGKTT 279

  Fly   180 FLPLVILDDCRNKKSNVKIMCIERQAILATYNSQRTANFFGEQLG---ETVGIQLPYFSAVSSST 241
            .:|..:.:...:.:.:: |...|.:.:.|...|||.|    :::.   ..|..|:.|...|:..|
  Rat   280 QVPQFLYEAGYSSEDSI-IGVTEPRRVAAVAMSQRVA----KEMNLSHRVVSYQIRYEGNVTEET 339

  Fly   242 FIIYSTAQYFLRSLTSQQFRNISH--LVVNDVHLHDPYTDILLS----EIRMALSSHQNLRVVLL 300
            .|.:.|....|:.: .:.|..:.:  :::::.|....||||||.    .:.:....|..|:::::
  Rat   340 RIKFMTDGVLLKEI-QKDFLLLKYKVVIIDEAHERSVYTDILLGLLSRIVALRAKRHLPLKLLIM 403

  Fly   301 SQMGNPKKFTDFFGEGLQLNMIKQPEVAPRVSYLNELHSCIALAGIHKGPDIYKEIPEA--FRAN 363
            |.....:.||.      ...:...|....:|.                    .::.|..  |...
  Rat   404 SATLRVEDFTQ------NQRLFTTPPPVIKVE--------------------SRQFPVTVHFNKR 442

  Fly   364 NPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPV-NYRHSLTGKTAVH-FASELNKANHLRL 426
            .|.::...:|.:...::              :.:.|. .....|||:..|| ....|.||..:|.
  Rat   443 TPLDDYSGECFRKVCKI--------------HRMLPAGGILVFLTGQAEVHALCRRLRKAFPIRC 493

  Fly   427 LLFMGADPYIVD--------LFQQN--------AISLAAMNGNHECIDVLNSYSL----HGYVVK 471
                 :.|..::        .|:::        |::|..:|        |::||:    .|...:
  Rat   494 -----SQPQEMEEDSAEGMRRFKKSRTRARKAQAMALPQIN--------LDNYSVLPAGEGDEDR 545

  Fly   472 SAKPD----FVDYDLIIDIMYLLRTKPEYSPGEYSPGNI-LIILPTYYHIVKLNYMILSHCLTGS 531
            .|:.|    .:..||.:|:     ...|.:.||....:: |.:||.|             .|...
  Rat   546 EAEMDDEEEALGSDLDLDL-----GDSEANEGEQPDASLPLHVLPLY-------------SLLAP 592

  Fly   532 LQECSIFLLYDNMRNDYLQALVNASDETVKVVLATDIIESLCLKVP-FKYQIDTACRLNNVYDTT 595
            .::..:|              ....:.|...|:||::.|: .|.:| .||.:|........||..
  Rat   593 EKQAQVF--------------KPPPEGTRLCVIATNVAET-SLTIPGIKYVVDCGKVKKRYYDRV 642

  Fly   596 SCSGDDRFEWVAK---DALLRRELILQPNKGDVQCFRLISKEAYEELSETSQPSLQTMQLDKICL 657
            :.....|..||::   |....|....:|.    .|:||.|...:.:..:...|.:....::.:.|
  Rat   643 TGVSSFRVTWVSQASADQRAGRAGRTEPG----HCYRLYSSAVFGDFEQFPPPEITRRPVEDLIL 703

  Fly   658 AVKLLSPNTIISEYLGITISPPPLINVHHAVQFL----------------KKIDVLDDAEDVTWL 706
            .:|.|:    |.:.:......||.:....|.:.|                ||:.:...:..:|.|
  Rat   704 QMKALN----IEKVINFPFPTPPSVEALIAAEELLIALGALQAPPKQERMKKLQMSQLSCPITAL 764

  Fly   707 GCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSI 771
            |..:...||:.:..:||.......||...:.||::::..:     ..|::|
  Rat   765 GRTMSTFPVAPRYAKMLALSQQHGCLPYTIAIVAAMTVRE-----LFEELD-------------- 810

  Fly   772 KKERTYLSDNQFSD----HFIFVRLYKEWQNRMHNRTPPLYLKD-----------EY-----EF- 815
               |...|:.:.::    .....::.:.|.    .:...|.|.|           ||     :|
  Rat   811 ---RPAASEEELAELKGRRTRVAQMKRTWA----GQGASLKLGDLMVLLGAVGACEYAGCSPQFC 868

  Fly   816 MLNGL----MEQLTSIRSEIVSSLRA----ANLIHSRGKLSMNNLNQMSCNWHMVKAALTGGMYP 872
            ..|||    |.::..:|.::.:::.|    |.|... .|:.....:|::....::.|.|...:..
  Rat   869 QANGLRYKAMLEIRRLRGQLTTAVNAVCPEAGLFLD-PKMQPPTESQVTYLRQIMAAGLGDHLAR 932

  Fly   873 NIYAVDTRKSSLKSAF-----SGNVSMHPNTVL 900
            .:.:.|......|:|:     ...|.:||::||
  Rat   933 RVQSEDLLDPKWKNAYKTPLLDDPVFIHPSSVL 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	10/32 (31%)
		ANK	407..>460	CDD:238125	13/69 (19%)
		Ank_2	413..>460	CDD:289560	10/63 (16%)
		HrpA	<484..973	CDD:224557	85/472 (18%)
		HA2	694..763	CDD:214852	13/68 (19%)
		OB_NTP_bind	823..945	CDD:285018	16/87 (18%)
Dhx37	NP_001099396.2	HrpA	236..1009	CDD:224557	151/866 (17%)
		DEXDc	267..407	CDD:238005	28/145 (19%)
		HELICc	578..667	CDD:197757	23/116 (20%)
		HA2	730..781	CDD:282288	8/50 (16%)
		HA2	761..852	CDD:214852	19/116 (16%)
		OB_NTP_bind	887..1004	CDD:285018	15/80 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900