DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and Dhx8

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	XP_006247348.1	Gene:	Dhx8 / 287727	RGDID:	1310723	Length:	1242	Species:	Rattus norvegicus

Alignment Length:	928	Identity:	180/928 - (19%)
Similarity:	323/928 - (34%)	Gaps:	299/928 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 PKTLVLSSGATLNMFTLLSRKSLMGKEDLELYADLVSMKANASDLP---SLHL--PLP------- 127
            |..:|.:...:|:...::  :|.:.||..||  .....:|....:|   :.|.  |||
  Rat   483 PIKIVKNPDGSLSQAAMM--QSALAKERREL--KQAQREAEMDSIPMGLNKHWVDPLPDAEGRQI 543

  Fly   128 -------AIRPPNLRFWTEAQLNFLTAFLG----------------HSLSDEILQSLYASRVIVY 169
                   .:.|.::..|.:.......|..|                :.|.::::|:::.:::::.
  Rat   544 AANMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIV 608

  Fly   170 NAALCWDKSVFLPLVILDDCRNKKSNVKIMCIERQAILATYNSQRTANFFGEQLGETVGIQLPYF 234
            .......|:..:...:.:  ....|..||.|.:.:.:.|...::|.:..||..||:.||..:.:.
  Rat   609 IGETGSGKTTQITQYLAE--AGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFE 671

  Fly   235 SAVSSSTFIIYSTAQYFLRS-LTSQQFRNISHLVVNDVHLHDPYTDILLSEIRMALSSHQNLRVV 298
            ...|..|.|.|.|....||. |........:.:::::.|....:||:|...::..:...|:::::
  Rat   672 DCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLI 736

  Fly   299 LLSQMGNPKKFTDFFGEG-----------LQLNMIKQPEVAPRVSYLNELHSCIALAGIHKGPDI 352
            :.|...:..||:.:|.|.           :::...|:||    ..||:.  |.|.:..||
  Rat   737 VTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPE----TDYLDA--SLITVMQIH----- 790

  Fly   353 YKEIPEAFRANNPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASE 417
                     ...|                                 |.:....|||:..:..|.|
  Rat   791 ---------LTEP---------------------------------PGDILVFLTGQEEIDTACE 813

  Fly   418 LNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVKSAKPDFVDYDL 482
            :                    |:::                           :||..||.
  Rat   814 I--------------------LYER---------------------------MKSLGPDV----- 826

  Fly   483 IIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHCLTGSLQECSIFLLYDNMRND 547
                       ||           |||||.|            ..|...:|.    .::|
  Rat   827 -----------PE-----------LIILPVY------------SALPSEMQT----RIFD----- 848

  Fly   548 YLQALVNASDETVKVVLATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALL 612
                  .|...:.|||:||:|.|:........|.:|.......||:  |.:|.|
  Rat   849 ------PAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYN--SKTGID----------- 894

  Fly   613 RRELILQP--------------NKGDVQCFRLISKEAY-EELSETSQPSLQTMQLDKICLAVKLL 662
              :|::.|              ..|..:|:||.::.|| :|:..|:.|.:|...|....|::|.:
  Rat   895 --QLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAM 957

  Fly   663 SPNTIIS-EYLGITISPPPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFG 726
            ..|.::| :::    ..||:..:..|::.|..:..|||...:|.||.|:.:.|:...|.:|||..
  Rat   958 GINDLLSFDFM----DAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMS 1018

  Fly   727 ILLRCLDPILTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKKERTYLSDNQFSDHFIFVR 791
            :.|.|.:.:|||||.||..:....|  :|...|.|:         ||.:.:.::   .||...:.
  Rat  1019 VHLGCSEEMLTIVSMLSVQNVFYRP--KDKQALADQ---------KKAKFHQTE---GDHLTLLA 1069

  Fly   792 LYKEWQNRMHNRTPPLYLKDEYEFMLNGLMEQLTSIRSEIVSSLRAANLIHSR--GKLSMNNLNQ 854
            :|..|:|...: .|..|             |.....|     |||.|..|..:  |.:..:.|:.
  Rat  1070 VYNSWKNNKFS-NPWCY-------------ENFIQAR-----SLRRAQDIRKQMLGIMDRHKLDV 1115

  Fly   855 MSCNWHMVKA--ALTGGMYPNIYAVDTRKSSLKSAFSGNVSMHPNTVLRDFLEPLNISAQSFRTP 917
            :||....|:.  |:..|.:.|....|.::..........|.:||::.|
  Rat  1116 VSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSAL----------------- 1163

  Fly   918 WIVCNRQKSHIVYATLVV 935
               .|||...:||..||:
  Rat  1164 ---FNRQPEWVVYHELVL 1178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	5/31 (16%)
		ANK	407..>460	CDD:238125	5/52 (10%)
		Ank_2	413..>460	CDD:289560	3/46 (7%)
		HrpA	<484..973	CDD:224557	108/472 (23%)
		HA2	694..763	CDD:214852	25/68 (37%)
		OB_NTP_bind	823..945	CDD:285018	26/117 (22%)
Dhx8	XP_006247348.1	S1_DHX8_helicase	287..365	CDD:240189
		DEXDc	583..768	CDD:214692	33/186 (18%)
		DEXDc	604..742	CDD:238005	27/139 (19%)
		HELICc	767..924	CDD:238034	51/325 (16%)
		HA2	986..1068	CDD:214852	29/95 (31%)
		OB_NTP_bind	1102..1201	CDD:285018	20/97 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810