DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bgcn and Dhx40

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_001005873.1	Gene:	Dhx40 / 287595	RGDID:	1359618	Length:	779	Species:	Rattus norvegicus

Alignment Length:	772	Identity:	149/772 - (19%)
Similarity:	252/772 - (32%)	Gaps:	245/772 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 SQRTANFFGEQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLRS-LTSQQFRNISHLVVNDVHLHD 275
            :||.|......||..||.|:.:....|..|.|.|.|....|:. |........|.:::::.|...
  Rat   115 AQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLNKFSVIILDEAHERT 179

  Fly   276 PYTDILLSEIRMAL-----SSHQNLRVVLLSQMGNPKKFTDFFGEGLQLNMIKQPEVAPRVSYLN 335
            ..||||...::...     :..::|:||::|......|.:.|||
  Rat   180 LTTDILFGLLKKLFQDKSPNRKEHLKVVVMSATMELAKLSAFFG--------------------- 223

  Fly   336 ELHSCIALAGIHKGPDIYKEIPEAF-RANNPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAP 399
               :|    .|...|.....:.|.| ....||:.:....:||..::..|..|......:..
  Rat   224 ---NC----PIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTMDIHLNEMAGDILV---- 277

  Fly   400 VNYRHSLTGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYS 464
                 .|||:..:..:.||                    |||.
  Rat   278 -----FLTGQFEIEKSCEL--------------------LFQM---------------------- 295

  Fly   465 LHGYVVKSAKPDFVDYDLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHCLT 529
                      .:.||||..:....|               :.|:|||.|
  Rat   296 ----------AESVDYDYDVQDTTL---------------DGLLILPCY---------------- 319

  Fly   530 GSLQECSIFLLYDNMRNDYLQALVNASDETVKVVLATDIIESLCLKVPFKYQIDTAC--RLNNVY 592
            ||:..       |..|..:|.......    |.|::|:|..:.......:|.:|...  :||:
  Rat   320 GSMTT-------DQQRRIFLPPPPGIR----KCVISTNISATSLTIDGIRYVVDGGFVKQLNH-- 371

  Fly   593 DTTSCSGDDRFEWV---AKDALLRRELILQPNKGDVQCFRLISKEAYEE-LSETSQPSLQTMQLD 653
              ....|.|..|.|   ..:||.|.....:...|  :|||:.||:.:.: :.:...|.::...|.
  Rat   372 --NPRLGLDILEVVPISKSEALQRSGRAGRTASG--KCFRIYSKDFWNQCMPDHVIPEIKRTSLT 432

  Fly   654 KICLAVKLLSPNTIIS-EYLGITISPPPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIPVSC 717
            .:.|.:|.|:.:.:|. .||    .||....:..|::.|.:.|.:|.:..||.||..:::.|:..
  Rat   433 SVVLTLKCLAIHDVIRFPYL----DPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPP 493

  Fly   718 QLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKKERTYLSDNQ 782
            .|...:|....|.|.|.:|.|.:.||                       ::|
  Rat   494 HLTCAVIRAASLDCEDLLLPIAAMLS-----------------------VEN------------- 522

  Fly   783 FSDHFIFVR-LYKEWQNRMHNRTPPLYLK----DEYEFMLNGLMEQLTSIRSEIVSSLRAANLIH 842
                 :|:| :..|:|.....:...|..|    :::. .|..:.||..|  |...:|....:.||
  Rat   523 -----VFIRPVDPEYQKEAEQKHRELAAKAGGFNDFA-TLAVIFEQCKS--SGAPASWCQKHWIH 579

  Fly   843 SRGKLS-----------MNNLNQMS---------CNWHMVKAALTGGMYPNIYAVDTRKSSLKSA 887
            .|...|           :..|.|.|         ....:::..|..|.:.|:     .:.|:...
  Rat   580 WRCLFSAFRVEAQLRELIRKLKQQSDFPRETFEGPKHEVLRRCLCAGYFKNV-----ARRSVGRT 639

  Fly   888 F------SGNVSMHPNTVLRDFLEPLNISAQSFRTPWIVCNR-QKSHIVYATLVVPL 937
            |      ...|.:||::.|.:         |..:..||:.:. ..:..|||.:|.|:
  Rat   640 FCTMDGRGSPVHIHPSSALHE---------QETKLEWIIFHEVLVTTKVYARIVCPI 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	5/31 (16%)
		ANK	407..>460	CDD:238125	7/52 (13%)
		Ank_2	413..>460	CDD:289560	5/46 (11%)
		HrpA	<484..973	CDD:224557	97/493 (20%)
		HA2	694..763	CDD:214852	16/68 (24%)
		OB_NTP_bind	823..945	CDD:285018	28/142 (20%)
Dhx40	NP_001005873.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		HrpA	51..750	CDD:224557	149/772 (19%)
		DEAH box	173..176		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900