DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bgcn and Dhx33

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_001099272.1	Gene:	Dhx33 / 287464	RGDID:	1307239	Length:	698	Species:	Rattus norvegicus

Alignment Length:	746	Identity:	135/746 - (18%)
Similarity:	263/746 - (35%)	Gaps:	249/746 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 IERQAILATYNSQRTANFF---------GEQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLR-SL 255
            |.||.|:|....:|.|...         ..:||:.||..:.:....|..|.|.:.|....|| ::
  Rat   107 ISRQGIIAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFEDVTSEDTRIKFLTDGMLLREAI 171

  Fly   256 TSQQFRNISHLVVNDVHLHDPYTDILLSEIRMALSSHQN-----LRVVLLSQMGNPKKFTDFFG- 314
            :....|..|.:::::.|....:||:|...::.|....:.     |:|:::|...:...|:.:|.
  Rat   172 SDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELGKLPLKVIVMSATMDVDLFSQYFNG 236

  Fly   315 ------EG----LQLNMIKQPEVAPRVSYLNELHSCIALAGIHKGPDIYKEIPEAFRANNPRNEQ 369
                  ||    :|:...|||:       .:.||:  ||..:.:   |::|.|.
  Rat   237 APVLYLEGRQHPIQIFYTKQPQ-------QDYLHA--ALVSVFQ---IHQEAPS----------- 278

  Fly   370 MDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNK--ANHLRLLLFMGA 432
                                    :.|:...     |||:..:...|:..:  |.||
  Rat   279 ------------------------SQDILVF-----LTGQEEIEAMSKTCRDIAKHL-------- 306

  Fly   433 DPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRTKPEYS 497
                                                                         |:..
  Rat   307 -------------------------------------------------------------PDGC 310

  Fly   498 PGEYSPGNILIILPTYYHIVKLNYMILSHCLTGSLQECSIFLLYDNMRNDYLQALVNASDETVKV 562
            |.       :::||.|   ..|.|                        :..|:....|.....||
  Rat   311 PS-------MLVLPLY---ASLPY------------------------SQQLRVFQGAPKGYRKV 341

  Fly   563 VLATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLRRELILQPNKGDVQ- 626
            :::|:|.|:.......||.:||.......|:.     |...|.:|...:.:.:...:..:...:
  Rat   342 IISTNIAETSITITGIKYVVDTGMVKAKKYNP-----DSGLEVLAVQRVSKTQAWQRTGRAGRED 401

  Fly   627 ---CFRLISKEAYEELSETSQPSLQTMQLDKI---CLAVKLLSPNTIISEYLGITISPPPLINVH 685
               |:||.:::.:::..:.:.|.:|...|..:   .||:|:  ||.:..:::.   .|.|    .
  Rat   402 SGICYRLYTEDEFDKFEKMAAPEIQRCNLASVMLQLLAMKV--PNVLTFDFMS---RPSP----D 457

  Fly   686 HAVQFLKKIDVL------DDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLST 744
            |....:.::|:|      ||...:|.:|.::...|:..:..:.::......|.:.||||||.||.
  Rat   458 HIEAAIAQLDLLGALEHKDDQLALTPIGRKMAAFPLEPKFAKTILLSSKFHCTEEILTIVSLLSV 522

  Fly   745 ADPL-GIPFTEDIDNLWDRFTIYIQNSIKKERTYLSDNQFSDHFIFVRLYKEWQNRMHNRTPPLY 808
            ...| ..|...|          .:|:..||   ::|..  .||...:.:|:.::|...|:.   :
  Rat   523 DSVLYNPPARRD----------EVQSVRKK---FISSE--GDHITLLNIYRTFKNIGGNKD---W 569

  Fly   809 LKDEYEFMLNGLMEQLTSIRSEI--VSSLRAANLIHSRGKLSMNNLNQMSCNWHMVKAALTGGMY 871
            .|:.:....|.|:  :..:|:::  :....:..::.|||  .|.::.:  |..|.:..: |..:.
  Rat   570 CKENFVNSKNMLL--VAEVRAQLRDICLKMSMPIMSSRG--DMESVRR--CLAHSLFMS-TAELQ 627

  Fly   872 PN-IYA-VDTRKSSLKSAFSGNVSMHPNTVL 900
            |: .|| .||.:.         |::||::||
  Rat   628 PDGTYATTDTHQP---------VAIHPSSVL 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	7/33 (21%)
		ANK	407..>460	CDD:238125	6/54 (11%)
		Ank_2	413..>460	CDD:289560	4/48 (8%)
		HrpA	<484..973	CDD:224557	85/435 (20%)
		HA2	694..763	CDD:214852	19/75 (25%)
		OB_NTP_bind	823..945	CDD:285018	18/82 (22%)
Dhx33	NP_001099272.1	DEXDc	49..252	CDD:214692	32/144 (22%)
		DEXDc	83..225	CDD:238005	27/117 (23%)
		Helicase_C	282..399	CDD:278689	29/229 (13%)
		HA2	469..554	CDD:214852	24/99 (24%)
		OB_NTP_bind	588..688	CDD:285018	17/76 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900