DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and Ythdc2

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_001156485.1	Gene:	Ythdc2 / 240255	MGIID:	2448561	Length:	1445	Species:	Mus musculus

Alignment Length:	1194	Identity:	295/1194 - (24%)
Similarity:	494/1194 - (41%)	Gaps:	235/1194 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 QFPCTFRTSEHEAFANNARSLGLRSQVVHVNGNSCVKVYKQ--------------------ACRH 70
            :||.:..::|.......::||||.|:......|..:.|.|:                    |.|.
Mouse    80 EFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKKDGSETAHAMMTCNLTHNTKHAVRS 144

  Fly    71 YLE------EPKTLVLSSGATLNMFTLLSRKSLMGKEDLELYADL--VSMKANASDLPSLHLPLP 127
            .::      :.:|.:|......|:|.:.:....|.|....|...:  |.:|...|:..|....||
Mouse   145 LIQRFPVTNKERTELLPKTERGNVFAVEAENREMSKTSGRLNNGIPQVPVKRGESEFDSFRQSLP 209

  Fly   128 AIRPPNLRFWTEAQLNFLTAFLGHSLSDEILQSLYASRVIVYNAALCWDKSVFLPLVILDDCRNK 192
            ..         |.|             :||::.:..::|::........|:..:|..:||||...
Mouse   210 VF---------EKQ-------------EEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKN 252

  Fly   193 KSNVKIMCIERQAILATYNSQRTANFFGEQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLRSLTS 257
            ....:|.|.:.:.:.|...::|.|....|::|:|:|.|:...|.||..|.:.:.|....||:|.:
Mouse   253 GIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMA 317

  Fly   258 --QQFRNISHLVVNDVHLHDPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFG------ 314
              .....::|::|::||..|.::|.||:::|..|..|..|:::|.|...:...|..:||
Mouse   318 GDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIY 382

  Fly   315 -------------------------EGLQLNMIKQPEVAPRVSYLNELHSC------------IA 342
                                     |.|:....||.|...:.: |.|.:|.            .|
Mouse   383 IQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREEKQQTT-LTEWYSAQENTFKPESQRQRA 446

  Fly   343 LAGIHKGPDIYKEIPEAFRANNPRNE----------QMDKCL-QAYGELGTDAALRPFLYAVNYD 396
            :|.:.:..|:..:..:|..:.....:          :||.|| ..:.....||..:.| :.:..:
Mouse   447 VASVSEEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDVDAFAQVF-HLILTE 510

  Fly   397 LAPVNYRHSLTGKTAVHFASELNKANHLRLLLFMGADPY--------------------IVDLFQ 441
            ...|:||||.|..||:..|:.....:.:..|:.|||:.:                    ||||.:
Mouse   511 NVSVDYRHSETSATALMVAAGRGFTSQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLE 575

  Fly   442 Q----------NAISLAAMNGNH---ECIDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRTK 493
            .          :..||...|||.   |..::|.:|. |.:     ..:.||.|||:.::|.:...
Mouse   576 SYSASLEFGNLDESSLVQTNGNDLSAEDRELLKAYH-HSF-----DDEKVDLDLIMHLLYNICHS 634

  Fly   494 PEYSPGEYSPGNILIILPTYYHIVKLNYMIL--SHCLTGSLQECSIFLLYDNMR-NDYLQALVNA 555
            .:       .|.|||.||.|..||.|...||  ......:.....:|:|:.||: :|..:.|.|.
Mouse   635 CD-------AGAILIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNP 692

  Fly   556 SDETVKVVLATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLRRELILQP 620
            .....|::|:|:|.|:........:.||:.......:|..:.....:..|::|.:.::|
Mouse   693 PAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQR------ 751

  Fly   621 NKGDVQ------CFRLISKEAYEELSETSQPSLQTMQLDKICLAVKLLSP-NTIISEYLGITISP 678
             ||...      ||||.|:..::.:.|...|.|..|.|.::||..|||:| |..|:::|.....|
Mouse   752 -KGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHTKLLAPVNCTIADFLMKAPEP 815

  Fly   679 PPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLS 743
            ||.:.|.:|||.||.||.:|..||:|.||..|.|:||...||:|::..::|:||||||||..:|:
Mouse   816 PPALIVRNAVQMLKTIDAMDAWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLA 880

  Fly   744 TADPLGIPFTEDIDNLWDRFTIYIQNSIKKE----RTYLSDNQFSDHFIFVRLYKEWQNRMHNRT 804
            ..||..:|               .|.|.|:.    |...:...||||...:|.::.||....:..
Mouse   881 YRDPFVLP---------------TQASQKRAAMLCRKRFTAGTFSDHMALLRAFQAWQKARSDGW 930

  Fly   805 PPLYLKDEYEFMLNGLMEQLTSIRSEIVSSLRAANLIHSRGKLSMNNLNQMSCNWHMVKAALTGG 869
            ...:.  |..|:....||.:..:|::::..|||:..:.:||...:.::|..|.||.:|||||..|
Mouse   931 ERAFC--EKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAG 993

  Fly   870 MYPNIYAVDTRKSSLKSAFSGNVSMHPNTVLRD----FLEPLNISA---QSFRTPWIVCNRQ-KS 926
            ||||:..||.....|.......|..||.:||..    .:.|.|..|   |:..|.|::.:.. ::
Mouse   994 MYPNLVHVDRENVILTGPKEKKVRFHPTSVLSQPQYKKIPPANGQAAAIQALPTDWLIYDEMTRA 1058

  Fly   927 H----IVYATLVVPLAVAMFSGHPRIRLSPI---------------CDSEM-SLTDRNVNVF-ID 970
            |    |...:.|.|:.|.:|.|..|:..:.:               .|||| ..|..|:... :|
Mouse  1059 HRIANIRCCSAVTPVTVLVFCGPARLASNALQEPSSFRADGIPNDSSDSEMEDRTTANLAALKLD 1123

  Fly   971 EWIWMVMSKATAEMVMRTRYYFFKMYHDLLKHCSELDMWRRDCEPVSQYTVLT-DTLSKIFESED 1034
            ||:...:....|.::::.|    :.:|.|.     |...|...:|.||....| ..:..:..:|:
Mouse  1124 EWLNFKLEPEAASLLLQLR----QKWHSLF-----LRRMRAPSKPWSQVDEATIRAIIAVLSTEE 1179

  Fly  1035 GFVGFFKPPPITFLPTP----QLP 1054
            ...|..:|..|...|.|    :||
Mouse  1180 QSAGLQQPSGIGQRPRPMSSEELP 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	9/51 (18%)
		ANK	407..>460	CDD:238125	18/85 (21%)
		Ank_2	413..>460	CDD:289560	15/79 (19%)
		HrpA	<484..973	CDD:224557	154/531 (29%)
		HA2	694..763	CDD:214852	28/68 (41%)
		OB_NTP_bind	823..945	CDD:285018	40/133 (30%)
Ythdc2	NP_001156485.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
		R3H_DEXH_helicase	61..119	CDD:100077	10/38 (26%)
		DEXDc	225..364	CDD:238005	38/138 (28%)
		DEAH box	331..334		0/2 (0%)
		ANK	502..587	CDD:238125	18/85 (21%)
		ANK repeat	520..552	CDD:293786	8/31 (26%)
		ANK 1	521..553		8/31 (26%)
		Ank_4	524..574	CDD:290365	10/49 (20%)
		ANK 2	554..586		4/31 (13%)
		ANK repeat	554..582	CDD:293786	4/27 (15%)
		Helicase_C	625..757	CDD:278689	33/145 (23%)
		HA2	831..916	CDD:214852	36/99 (36%)
		OB_NTP_bind	954..1081	CDD:285018	39/126 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1179..1303		7/25 (28%)
		YTH	1304..1434	CDD:282058
		N6-methyladenosine binding. /evidence=ECO:0000250\|UniProtKB:Q9Y5A9	1309..1311
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I12456
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4903
OMA	1	1.010	-	-		QHG48010
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106429
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.630