Protein Alignment bgcn and DHX30

DIOPT Version :10

• Sequence 1: NP_523832.2
• Gene: bgcn / 47873
• FlyBaseID: FBgn0004581
• Length: 1215
• Species: Drosophila melanogaster
• Sequence 2: XP_047303683.1
• Gene: DHX30 / 22907
• HGNCID: 16716
• Length: 1265
• Species: Homo sapiens
• Alignment Length: 1027
• Identity: 225/1027 - (21%)
• Similarity: 365/1027 - (35%)
• Gaps: 320/1027 - (31%)

  Fly    15 LYFLAGRR---CCQQFPCTFRTSEH-----EAFANN--------ARSLGLRSQVVHVNGNSCVKV 63
            :|.||..|   ..|:.|||.:..|.     |.|.|:        |..|.|:|..:...|.
Human   400 MYNLASLRELGETQRRPCTIQVPEPILRKIETFLNHYPVESSWIAPELRLQSDDILPLGK----- 459

  Fly    64 YKQACRHYLEEPKTLVLSSGATLNMFTLLSRKSLMGKEDLELYADLVSMKANASDLPSLHLPLPA 128
                             .||...:..|......|:..|::.|...|              |.|..
Human   460 -----------------DSGPLSDPITGKPYVPLLEAEEVRLSQSL--------------LELWR 493

  Fly   129 IRPPNLRFWTEA-QLNFLTAFLGHSLSDEILQSLYASRVIVYNAALCWDKSVFLPLVILD----D 188
            .|.|   .|.|| ||..      ....|.||.::....|:|.:......|:..:|.::|:    :
Human   494 RRGP---VWQEAPQLPV------DPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTE 549

  Fly   189 CRNKKSNVKIMCIERQAILATYNSQRTANFFGEQLGETVGIQLPYFS-AVSSSTFIIYSTAQYFL 252
            .|..:.||.|  .:.:.|.|...:||.::..|..|...||.|:...| ..|....:::.|....|
Human   550 GRGARCNVII--TQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPSRGGALLFCTVGILL 612

  Fly   253 RSLTSQ-QFRNISHLVVNDVHLHDPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFGEG 316
            |.|.|. ....:||::|::||..|..||.||..::.....:..||:||:|..|:.::|:.:||
Human   613 RKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFG-- 675

  Fly   317 LQLNMIKQPEVAPRVSYLNELHSCIALAGIHKGPDIYKEIPEAFRANNPRNEQMDKCLQAYGELG 381
             ...:||.|
Human   676 -GCPVIKVP-------------------------------------------------------- 683

  Fly   382 TDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAIS 446
                  .|:|.|.                                      :.|:.|:.
Human   684 ------GFMYPVK--------------------------------------EHYLEDIL------ 698

  Fly   447 LAAMNGNHECIDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRTKPEYSPGEYSPGNILIILP 511
              |..|.|:   .|:.:..|    :|.....:|.||:.|::..:..:.|       ||.||..||
Human   699 --AKLGKHQ---YLHRHRHH----ESEDECALDLDLVTDLVLHIDARGE-------PGGILCFLP 747

  Fly   512 TYYHIV-------------KLNYMILS-HCLTGSLQECSIFLLYDNMRNDYLQALVNASDETVKV 562
            .:..|.             :..|:||. |.....:.:.:||          .|..|...    |:
Human   748 GWQEIKGVQQRLQEALGMHESKYLILPVHSNIPMMDQKAIF----------QQPPVGVR----KI 798

  Fly   563 VLATDIIESLCLKVPFKYQIDTACRLNNVYD---TTSCSGDDRFEWVAKDALLRRELILQPNKGD 624
            ||||:|.|:........:.:|:.......||   ..||.   ...||::..:::|    :...|.
Human   799 VLATNIAETSITINDIVHVVDSGLHKEERYDLKTKVSCL---ETVWVSRANVIQR----RGRAGR 856

  Fly   625 VQ---CFRLISKEAYEELSETSQPSLQTMQLDKICLAVKLLSPNTIISEYLGITISPPPLINVHH 686
            .|   .:.|..:...|::.....|.:....|:.:.|..|:..|.....|:|...:..|.:..|..
Human   857 CQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDE 921

  Fly   687 AVQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIP 751
            ||..|::|.|||..|.:|.||.||..|....:|.:.::...:.|||.|:|.:||.| |.|    |
Human   922 AVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCL-TRD----P 981

  Fly   752 FTEDIDNLWDRFTIYIQNSIKKERTYLSDNQFSDHFIFVRL---YKE---WQNRMHNRTPPLYLK 810
            |:..:.|         :..:.|.:..||.:..|||..|||.   ::|   ||:|.....   ||:
Human   982 FSSSLQN---------RAEVDKVKALLSHDSGSDHLAFVRAVAGWEEVLRWQDRSSREN---YLE 1034

  Fly   811 DEYEF-----MLNGLMEQLTSIRSEIVSSLRAANLIHSRGKLSMNNLNQMSCNWH-----MVKAA 865
            :...:     .::||::|.:       .::..|.|:   ||.|...|....||.:     :||..
Human  1035 ENLLYAPSLRFIHGLIKQFS-------ENIYEAFLV---GKPSDCTLASAQCNEYSEEEELVKGV 1089

  Fly   866 LTGGMYPNIYAVDTRKSSLKSAF----------SGNVSMHPNTVLRDFLEPLNISAQSFRTPWI- 919
            |..|:|||:..|...|.:.:..|          |||:.:|.:|:.|:        |...|:.|:
Human  1090 LMAGLYPNLIQVRQGKVTRQGKFKPNSVTYRTKSGNILLHKSTINRE--------ATRLRSRWLT 1146

  Fly   920 ----VCNRQKSHIVYATLVVPLAVAMFSGHPRIRLSPICDSEMSLTDRNVNV 967
                |.:.....:..::.|.||||.:                  |||.:|::
Human  1147 YFMAVKSNGSVFVRDSSQVHPLAVLL------------------LTDGDVHI 1180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	DEAD-like_helicase_N	155..314	CDD:475120	45/164 (27%)
		ANKYR	<398..>460	CDD:440430	5/61 (8%)
		ANK repeat	406..438	CDD:293786	1/31 (3%)
		P-loop containing Nucleoside Triphosphate Hydrolases	465..>594	CDD:476819	32/145 (22%)
		HA2	687..789	CDD:461295	34/101 (34%)
		OB_NTP_bind	862..945	CDD:400182	25/97 (26%)
DHX30	XP_047303683.1	HrpA	497..>1029	CDD:441249	156/702 (22%)
		OB_NTP_bind	1086..1173	CDD:400182	25/112 (22%)