DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and Dhx29

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_766182.2	Gene:	Dhx29 / 218629	MGIID:	2145374	Length:	1365	Species:	Mus musculus

Alignment Length:	946	Identity:	214/946 - (22%)
Similarity:	364/946 - (38%)	Gaps:	217/946 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 SRKSLMGKEDLELYADLVSMKANASDLP---SLHLPLPAIRPPNLRFWTEAQLNFLTAFLGHSLS 154
            |.::|:..|||   |.|.....:|.||.   ||...|.: .|...|...|.|.  |..|   ...
Mouse   522 SWENLVSDEDL---AALSLEPTSAEDLAPVRSLFRRLQS-TPKYQRLLKERQQ--LPVF---KHR 577

  Fly   155 DEILQSLYASRVIVYNAALCWDKSVFLPL-----VILDDCRNKKSNVKIMCIERQAILATYNSQR 214
            |.|:::|...||:|........||..:|.     ::||:|..:|.|  |:|.:.:.|.|...:.|
Mouse   578 DSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLDECGARKCN--IVCTQPRRISAVSLATR 640

  Fly   215 TANFFGEQLG-----ETVGIQLPYFSAVSSSTFIIYSTAQYFLRSLTSQ-QFRNISHLVVNDVHL 273
            .....|.:.|     ...|.|:...|..|.||.::|.|....||.|... ...::||::|::||.
Mouse   641 VCEELGCESGPGGRNSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHE 705

  Fly   274 HDPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFF---------GEGLQLNMIKQPEVAP 329
            ....:|.||..::..|....:|.::|:|...:..||:.:|         |....:.:....::..
Mouse   706 RSVQSDFLLVILKEILQKRSDLHLILMSATVDSDKFSTYFTHCPILRISGRSYPVEVFHLEDIVE 770

  Fly   330 RVSYLNELHSCIALAGIHKGPDIYKEIPEAFRANNPRNEQMDKCLQAYGELGTDAALRPFLYAVN 394
            ...::.|..|                            |...|.|:...|:..:...:.......
Mouse   771 ETGFVLEKDS----------------------------EYCQKFLEEEEEITINVTSKAGGVKKY 807

  Fly   395 YDLAPVNYRHSLTGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDV 459
            .:..||.                            .||.|.:...:|:
Mouse   808 QEYIPVQ----------------------------SGASPELNPFYQK----------------- 827

  Fly   460 LNSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMIL 524
            .:|.:.|..:..:  |..::.|||::::..|...|::...|   |.:||.||...||.:| |.:|
Mouse   828 YSSRTQHAILYMN--PHKINLDLILELLVYLDKSPQFRNIE---GAVLIFLPGLAHIQQL-YDLL 886

  Fly   525 SHCLTGSLQECSIFLLYDNM-RNDYLQALVNASDETVKVVLATDIIESLCLKVPFKYQIDTACRL 588
            |.......:...:..|:..: ..|...|.:.......|:||||:|.|:........:.|||....
Mouse   887 SSDRRFYSERYQVIALHSVLSTQDQAAAFMFPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTK 951

  Fly   589 NNVYDTTSCSGDDRFEWVAKDALLRRELILQPNKGDVQ---CFRLISKEAYEELSETSQPSLQTM 650
            .|.|..:|........:|:|.:.|:|    |...|.|:   ||||.::|.:|...:.|.|.:..:
Mouse   952 ENKYHESSQMSSLVETFVSKASALQR----QGRAGRVRDGFCFRLYTRERFEGFLDYSVPEILRV 1012

  Fly   651 QLDKICLAV---KLLSPNTIISEYLGITISPPPLINVHHAVQFLKKIDVLDDAE-DVTWLGCRLM 711
            .|:::||.:   .|.||    .::|...:.||.|..:.:|:..|:||...:..| .:|.||..|.
Mouse  1013 PLEELCLHIMKCDLGSP----EDFLSKALDPPQLQVISNAMNLLRKIGACEPNEPKLTPLGQHLA 1073

  Fly   712 DIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPF--TEDIDNLWDRFTIYIQNSIKKE 774
            .:||:.::|:|||||.:..||:|:.|:.:.::...|...|.  .::.|             :.|.
Mouse  1074 ALPVNVKIGKMLIFGAIFGCLEPVATLAAVMTEKSPFITPIGRKDEAD-------------LAKS 1125

  Fly   775 RTYLSDNQFSDHFIFVRLYKEW----------------QNRMHNRTPPLYLKDEYEFMLNGLMEQ 823
            ...::|   |||......|..|                |....|||..|.|:|
Mouse  1126 SLAVAD---SDHLTIYNAYLGWKKAQQEGGFRSEISYCQRNFLNRTSLLTLED------------ 1175

  Fly   824 LTSIRSEIVSSLRAANLIHS---RGKLSMNNLNQMSCNWHMVKAALTGGMYPNIYAVDTRKS--- 882
               ::.|::..::||....|   .|:.....|:....  .::||.|..|:|.::..:...||
Mouse  1176 ---VKQELMKLVKAAGFSSSPSWEGRKGPQTLSFQDI--ALLKAVLAAGLYDSVGKIMCTKSVDV 1235

  Fly   883 -----SLKSAFSGNVSMHPNTVLRDFLEPLNISAQSFRTPWIVCNRQKSHI-VY---ATLVVPLA 938
                 .:.....|...:||::|.||.        |::  .|::...:..:. ||   .||:.|..
Mouse  1236 TEKLACMVETAQGKAQVHPSSVNRDL--------QTY--GWLLYQEKVRYTRVYLRETTLITPFP 1290

  Fly   939 VAMFSGHPRIRLSPICDSEMSLTDRNVNVFIDEWIW 974
            |.:|.|          |.|:...:|.::|  |.||:
Mouse  1291 VLLFGG----------DIEVQHRERLLSV--DGWIY 1314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	3/31 (10%)
		ANK	407..>460	CDD:238125	4/52 (8%)
		Ank_2	413..>460	CDD:289560	4/46 (9%)
		HrpA	<484..973	CDD:224557	127/529 (24%)
		HA2	694..763	CDD:214852	21/71 (30%)
		OB_NTP_bind	823..945	CDD:285018	28/136 (21%)
Dhx29	NP_766182.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..74
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..222
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..257
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..524		1/1 (100%)
		DEXDc	577..763	CDD:214692	48/187 (26%)
		DEXDc	588..735	CDD:238005	41/148 (28%)
		DEAH box. /evidence=ECO:0000255\|HAMAP-Rule:MF_03068	701..704		0/2 (0%)
		Helicase_C	863..984	CDD:278689	34/128 (27%)
		HA2	1055..1136	CDD:214852	26/96 (27%)
		OB_NTP_bind	1178..1298	CDD:285018	29/141 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810