DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and Dhx33

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_848144.3	Gene:	Dhx33 / 216877	MGIID:	2445102	Length:	698	Species:	Mus musculus

Alignment Length:	744	Identity:	137/744 - (18%)
Similarity:	262/744 - (35%)	Gaps:	245/744 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 IERQAILATYNSQRTANFF---------GEQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLR-SL 255
            |.||.|:|....:|.|...         ..:||:.||..:.:....|..|.|.:.|....|| ::
Mouse   107 ISRQGIIAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFEDVTSEDTRIKFLTDGMLLREAI 171

  Fly   256 TSQQFRNISHLVVNDVHLHDPYTDILLSEIRMALSSHQN-----LRVVLLSQMGNPKKFTDFFG- 314
            :....|..|.:::::.|....:||:|...::.|....:.     |:|:::|...:...|:.:|.
Mouse   172 SDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELGKLPLKVIVMSATMDVDLFSQYFNR 236

  Fly   315 ------EG----LQLNMIKQPEVAPRVSYLNELHSCIALAGIHKGPDIYKEIPEAFRANNPRNEQ 369
                  ||    :|:...|||:       .:.||:  ||..:.:   |::|.|
Mouse   237 APVLYLEGRQHPIQIFYTKQPQ-------QDYLHA--ALVSVFQ---IHQEAP------------ 277

  Fly   370 MDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNKANHLRLLLFMGADP 434
                                   .:.|:...     |||:..:...|:
Mouse   278 -----------------------ASQDILVF-----LTGQEEIEAMSK----------------- 297

  Fly   435 YIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRTKPEYSPG 499
                                .|.|:                              .|..|:..|.
Mouse   298 --------------------TCRDI------------------------------ARHLPDGCPS 312

  Fly   500 EYSPGNILIILPTYYHIVKLNYMILSHCLTGSLQECSIFLLYDNMRNDYLQALVNASDETVKVVL 564
                   :::||.|   ..|.|                        :..|:....|.....||::
Mouse   313 -------MLVLPLY---ASLPY------------------------SQQLRVFQGAPKGYRKVII 343

  Fly   565 ATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLRRELILQPNKGDVQ--- 626
            :|:|.|:.......||.:||.......|:.     |...|.:|...:.:.:...:..:...:
Mouse   344 STNIAETSITITGIKYVVDTGMVKAKKYNP-----DSGLEVLAVQRVSKTQAWQRTGRAGREDSG 403

  Fly   627 -CFRLISKEAYEELSETSQPSLQTMQLDKI---CLAVKLLSPNTIISEYLGITISPPPLINVHHA 687
             |:||.:::.:|:..:.:.|.:|...|..:   .||:|:  ||.:..:::.   .|.|    .|.
Mouse   404 ICYRLYTEDEFEKFEKMTVPEIQRCNLASVILQLLAMKV--PNVLTFDFMS---KPSP----DHI 459

  Fly   688 VQFLKKIDVL------DDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTAD 746
            ...:.::|:|      ||...:|.:|.::...|:..:..:.::......|.:.||||||.||...
Mouse   460 EAAIAQLDLLGALEHKDDQLTLTPIGRKMAAFPLEPRFAKTILLSSKFHCTEEILTIVSLLSVDS 524

  Fly   747 PL-GIPFTEDIDNLWDRFTIYIQNSIKKERTYLSDNQFSDHFIFVRLYKEWQNRMHNRTPPLYLK 810
            .| ..|...|          .:|:..||   ::|..  .||...:.:|:.::|...|:.   :.|
Mouse   525 VLYNPPARRD----------EVQSVRKK---FISSE--GDHITLLNIYRTFKNIGGNKD---WCK 571

  Fly   811 DEYEFMLNGLMEQLTSIRSEI--VSSLRAANLIHSRGKLSMNNLNQ-MSCNWHMVKAAL-TGGMY 871
            :.:....|.|:  :..:|:::  :....:..::.|||  .|.::.: |:.:..|..|.| |.|.|
Mouse   572 ENFVNSKNMLL--VAEVRAQLREICLKMSMPIMSSRG--DMESVRRCMAHSLFMNTAELQTDGTY 632

  Fly   872 PNIYAVDTRKSSLKSAFSGNVSMHPNTVL 900
            .   ..||.:.         |::||::||
Mouse   633 A---TTDTHQP---------VAIHPSSVL 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	4/31 (13%)
		ANK	407..>460	CDD:238125	5/52 (10%)
		Ank_2	413..>460	CDD:289560	3/46 (7%)
		HrpA	<484..973	CDD:224557	88/435 (20%)
		HA2	694..763	CDD:214852	19/75 (25%)
		OB_NTP_bind	823..945	CDD:285018	19/82 (23%)
Dhx33	NP_848144.3	Required for nucleolar location. /evidence=ECO:0000250\|UniProtKB:Q9H6R0	1..71
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..50
		DEXDc	49..252	CDD:214692	32/144 (22%)
		DEXDc	83..225	CDD:238005	27/117 (23%)
		DEAH box	185..188		0/2 (0%)
		Helicase_C	282..399	CDD:278689	29/227 (13%)
		IBP39	409..>500	CDD:288304	19/99 (19%)
		HA2, required for interaction with EIF3G and RPL26. /evidence=ECO:0000250\|UniProtKB:Q9H6R0	462..553		25/105 (24%)
		HA2	469..554	CDD:214852	24/99 (24%)
		Critical for rDNA-binding	536..550		4/18 (22%)
		OB_NTP_bind	588..688	CDD:285018	18/76 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900