DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and smgl-2

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_001294374.1	Gene:	smgl-2 / 177135	WormBaseID:	WBGene00021365	Length:	1089	Species:	Caenorhabditis elegans

Alignment Length:	927	Identity:	164/927 - (17%)
Similarity:	310/927 - (33%)	Gaps:	342/927 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 EILQSLYASRVIVYNAALCWDKSVFLPLVILDDCRNKKSNVKIMCIERQAILATYNSQRTANFFG 220
            ||::.|..::|::........||..:|..:|     |.....:.|.:.:.|..|..::|.|....
Worm   152 EIVELLKTNQVLIVAGDTGCGKSTQVPQYLL-----KAGFTGVACTQPRRIACTALARRVAYETL 211

  Fly   221 EQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLRSLTSQQ-FRNISHLVVNDVHLHDPYTDILLSE 284
            .|.|..|..|:.:.:..|..|.:::.|....||.:.... ....:.:::::||.....:|:|:..
Worm   212 NQYGSEVAFQIRFETTKSQKTKLLFLTEGLLLRQMEKDSLLEKYNVIILDEVHERHLTSDLLIGL 276

  Fly   285 IRMALSSHQNLRVVLLSQMGNPKKFTDFFGEGLQLNMIKQPEVAPRVSYLNELHSCIALAGIHKG 349
            :|...:...:|:::|:|...|...|..:|            |.||.|
Worm   277 LRDLCTKRDDLKLILMSATINLDLFKGYF------------EGAPVV------------------ 311

  Fly   350 PDIYKEIPEAFRANNPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYR-HSLTGKTAVH 413
                 ::|..                                     |.|::.| |.:.     .
Worm   312 -----QVPGR-------------------------------------LFPIDVRWHPIK-----Q 329

  Fly   414 FASELNKANHLRLLLFMGADPY--IVDLFQ------QNAISLAAMNGNHECIDVLNSYSLHGYVV 470
            |..:.:|..|.     :..:||  |::|..      |...:|..:||
Worm   330 FIDQSDKKTHK-----IDPEPYLKILELIDKQFPSTQRGDALIFLNG------------------ 371

  Fly   471 KSAKPDFVDYDLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHCLTGSLQEC 535
                        :.:|..:......|:  |.:.|.|:::|.:                |.|::|
Worm   372 ------------VAEISMVAEHLKNYA--ELTNGWIILMLHS----------------TLSVEE- 405

  Fly   536 SIFLLYDNMRNDYLQALVNASDETVKVVLATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGD 600
                 .|.:   :.||.|...    |.:|:|::.|:.......::.||:. ::|.:.........
Worm   406 -----QDKV---FDQAPVGIR----KCILSTNVAETSVTIDGIRFVIDSG-KVNLIKHEPGTGTQ 457

  Fly   601 DRFE-WVAKDALLRRELILQPNKGDVQ------CFRLISKEAYEEL-----SETSQPSLQTMQLD 653
            ...| ||:|.:..:|       ||...      |:||.|:|.:|::     ||.::.|||.|
Worm   458 KLTEFWVSKASANQR-------KGRAGRTGPGICYRLYSQEQFEKMDDFTVSEINRVSLQEM--- 512

  Fly   654 KICLAVKLLSPNTIISEYLGITISPPPLIN------VHHAVQFLKKIDVL-DDAEDV---TWLGC 708
                |:|::|.|      ||:.....|.|.      ::..::.||...|| .|..|:   |.||.
Worm   513 ----ALKMISLN------LGLDPRTFPFIEKPSEDVLNEGLEVLKFQRVLRSDRGDILTLTALGN 567

  Fly   709 RLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKK 773
            .:..:||...:.:||::|.::..|:.:||:.:.||...    |||.         ..|.:..|.:
Worm   568 MVSKLPVEVPIAKMLVYGCVVDELEVMLTVAAGLSVQS----PFTN---------RSYRELEIVE 619

  Fly   774 ERTYLSDNQFSDHFIFVRLYKEWQNRMHNRTPPLYLKDEYE------FMLNGLME----QLTSIR 828
            .|..|: :...|.|..:.:::||           .|:..:|      .|.||:.|    :::.:|
Worm   620 RRASLT-SPLGDPFTLISIFREW-----------VLQKAFEGTARRWTMENGIDEHRLYEISKLR 672

  Fly   829 SEIVSSLRAANLIHSRG-------------------------KLSMNNLNQ----MSCNWH---- 860
            ::....|..|.|:....                         |.|..|.::    ::.|.|
Worm   673 AQYRQILEDAGLVEKASAAETGEDDSRQRRIDQGEKRKLFDLKKSQRNNDRRQKVLNANKHFDKI 737

  Fly   861 -------------------------------------------------MVKAALTGGMYPNIYA 876
                                                             :|:..:..|:|||...
Worm   738 LEDKEEEDLEAEKDPLKADVKTVEFLLSHKQRDVENIRKTHKISRKTAEVVRVIIAAGLYPNFSI 802

  Fly   877 VDT-------RKSSLKSAFSGNVSMHPNTVLRDF----LEPLNIS---AQSFRTPW--------- 918
            :|.       ::....:.......:|||:.:..:    ::|...|   ::..:.|:
Worm   803 LDPVNKYGYGQEMFTHTRLKPFTQIHPNSSIAQYHPETIDPRQGSDGFSRLHQIPFYGLLLETTK 867

  Fly   919 -IVCNRQKSHIVYATLV 934
             .:||......||..||
Worm   868 PYICNVMPVPAVYTLLV 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	6/33 (18%)
		ANK	407..>460	CDD:238125	11/60 (18%)
		Ank_2	413..>460	CDD:289560	11/54 (20%)
		HrpA	<484..973	CDD:224557	110/589 (19%)
		HA2	694..763	CDD:214852	20/72 (28%)
		OB_NTP_bind	823..945	CDD:285018	27/218 (12%)
smgl-2	NP_001294374.1	DEXDc	130..330	CDD:214692	43/259 (17%)
		DEXDc	161..296	CDD:238005	28/139 (20%)
		Helicase_C	350..480	CDD:278689	32/198 (16%)
		HA2	561..635	CDD:214852	22/87 (25%)
		OB_NTP_bind	<775..888	CDD:285018	18/110 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910