DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and ddx-35

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_497420.1	Gene:	ddx-35 / 175308	WormBaseID:	WBGene00022056	Length:	732	Species:	Caenorhabditis elegans

Alignment Length:	810	Identity:	153/810 - (18%)
Similarity:	264/810 - (32%)	Gaps:	285/810 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 MKANASDLPSLHLPLPAIRPPNLRFWTEAQLNFLTAFLGHSLSDEILQSLYASRVIVYNAALCWD 176
            :|.:.:...||::....||.|            :....||     ||......|.|:........
Worm    58 LKVHNNPYASLNIQQQRIRLP------------IFKNRGH-----ILYMCERYRTIIIVGETGCG 105

  Fly   177 KSVFLPLVILD-----DCRNKKSNVKIMCIERQAI--LATYNSQRTANFFGEQLGETVGIQLPYF 234
            ||..:|..:|:     |.|    .:.|....|.|:  |||..::......|..:|.||     .|
Worm   106 KSTQVPQFLLEAGWAADGR----QIVITQPRRVAVVTLATRVAEEKDCILGHDVGYTV-----RF 161

  Fly   235 SAVS-SSTFIIYSTAQYFLRS-LTSQQFRNISHLVVNDVHLHDPYTDILLSEIRMALSSHQNLRV 297
            ..|| ..|.:.:.|....||. |........|.:::::.|.....|||||..:|..:....:||:
Worm   162 DDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDLRI 226

  Fly   298 VLLSQMGNPKKFTDFFGEGLQLNMIKQPEVAPRVSYLNELHSCIALAGIHKGPDIYKEIPEAFRA 362
            ::.|...:.:.|.||                                               |..
Worm   227 IVSSATLDAELFKDF-----------------------------------------------FEM 244

  Fly   363 NNPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNKANHLRLL 427
            |...|...|..    |.:..:....|                     .|||.
Worm   245 NETGNSDKDTA----GIISVEGRTHP---------------------VAVHH------------- 271

  Fly   428 LFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVKSAKPDFVD--YDLIIDIMYLL 490
                                                      .|::.||:..  .|.:|:|
Worm   272 ------------------------------------------TKTSVPDYCQSAVDTVINI---- 290

  Fly   491 RTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHC-----LTGSLQECS---IFLLYDNM-RN 546
             .|.|      :||:||:.|.....:..:       |     |.|:|:.|.   :...|..: ..
Worm   291 -HKHE------NPGDILVFLTGQDEVEDV-------CEKLRELAGNLKNCDRLWVVPCYGALPAR 341

  Fly   547 DYLQALVNASDETVKVVLATDIIESLCLKVP-FKYQIDT------ACRLNNVYDT------TSCS 598
            :.::|..:....|.|||:||:|.|: .:.:| ..|.|||      |....|..:|      :..|
Worm   342 EQMKAFDSTPHGTRKVVVATNIAEA-SITIPGICYVIDTGYVKLRAQHAANGVETLMRVTVSKAS 405

  Fly   599 GDDRFEWVAKDALLRRELILQPNKGDVQCFRLISKEAYEELSETSQPSLQTMQLDKICLAVKLLS 663
            .:.|.....:         ::|.|    |:||..:..:|..:|.:.|.:|..|:....|.:|.|.
Worm   406 AEQRAGRAGR---------IRPGK----CYRLYPESEFERFAEGTVPEIQRCQMASTILQLKALG 457

  Fly   664 -PNTIISEYLGITISPPPLINVHHAVQFLKKIDVLDDAEDVTW-LGCRLMDIPVSCQLGRMLIFG 726
             .|.....||    ||||...:.:.::.|..:..:|:...:|. ||.::.:.|:.....:.|:..
Worm   458 VQNVHRFHYL----SPPPSWAMINGLELLYALGAIDETSQLTSPLGLQMAEFPLPPMHSKCLLKS 518

  Fly   727 ILLRCLDPILTIVSSLSTADPLGIPFTE----------------DIDNLWDRFTIYIQNSIKKER 775
            ....|...::|||:.:...|....|:.:                |...:.:.||.:::|...|:
Worm   519 AEFGCSTEMVTIVAMMQIQDVFITPYRQRHQADVIRKKFAVEEGDHMTMLNVFTKFVENGRSKK- 582

  Fly   776 TYLSDNQFSDHFIFVRLYKEWQNRMHNRTPPLYLKDEYEFMLNGLMEQLTSIRSEIVSSLRAANL 840
                  ..||||:..|                           ||| :..::||::|..|:...:
Worm   583 ------WCSDHFVNYR---------------------------GLM-RADNVRSQLVRLLKRFEI 613

  Fly   841 --IHSRGKLSMNNLNQMSCNWHMVKAALTG 868
              :.|||.:        :|:.::.:..:||
Worm   614 EKVSSRGLI--------NCSENIRQCLVTG 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	3/31 (10%)
		ANK	407..>460	CDD:238125	3/52 (6%)
		Ank_2	413..>460	CDD:289560	1/46 (2%)
		HrpA	<484..973	CDD:224557	90/427 (21%)
		HA2	694..763	CDD:214852	13/85 (15%)
		OB_NTP_bind	823..945	CDD:285018	10/48 (21%)
ddx-35	NP_497420.1	HrpA	70..702	CDD:224557	150/798 (19%)
		DEXDc	96..233	CDD:238005	36/145 (25%)
		Helicase_C	284..416	CDD:278689	35/159 (22%)
		HA2	484..568	CDD:214852	13/83 (16%)
		OB_NTP_bind	602..704	CDD:285018	9/42 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900