DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and rha-1

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_495890.2	Gene:	rha-1 / 174417	WormBaseID:	WBGene00004355	Length:	1301	Species:	Caenorhabditis elegans

Alignment Length:	1135	Identity:	240/1135 - (21%)
Similarity:	402/1135 - (35%)	Gaps:	322/1135 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 EEPKTLVLSSGATLNMFTLLSRKSLMGKEDLELYADLVSMKANASDLPSLHLPLPAIRPPNLRFW 137
            |||.       |.::|..:..|  :|.|||.:....|..:.|...:||
Worm   344 EEPL-------AFMSMEQISQR--IMEKEDFKRGEALDKITAQRGELP----------------- 382

  Fly   138 TEAQLNFLTAFLGHSLSDEILQSLYASRVIVYNAALCWDKSVFLPLVILDDCRNKKSNVKIMCIE 202
             .||..           :.|:|::..:||.:........||..:...:|:......:......:.
Worm   383 -VAQYR-----------ENIVQTVAENRVTLIKGETGCGKSTQVAQFLLESFLENSNGASFNAVV 435

  Fly   203 RQ--AILATYNSQRTANFFGEQLGETVGIQLPYFSAVSSS-TFIIYSTAQYFLRSLTSQQFRNIS 264
            .|  .|.|...::|.||..||::|||.|..:.:.||.... ..|::.|....|| :.....|.||
Worm   436 SQPRRISAISLAERVANERGEEVGETCGYNVRFDSATPRPYGSIMFCTVGVLLR-MMENGLRGIS 499

  Fly   265 HLVVNDVHLHDPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFGEGLQLNMIKQPEVAP 329
            |::::::|..|..||.:|..:|..:|::::|||||:|...:...||:||.        ..|:|.|
Worm   500 HVIIDEIHERDVDTDFVLIVLREMISTYRDLRVVLMSATIDTDLFTNFFS--------SIPDVGP 556

  Fly   330 -------------RVSYLNE-LHSCIALAGIHKGPDIYKEIPEAFRANNPRNEQMDKCLQAYGEL 380
                         :..||.: ||:   |..:.:.||..|.     :...|.....|:..:...:.
Worm   557 TPVITMHGRTFPVQSFYLEDILHN---LQHMPEEPDQKKR-----KKGGPPPPDDDEGDEEVDDK 613

  Fly   381 GTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAI 445
            |.:..:          |...:...||  |||:...||.:                         |
Worm   614 GRNMNI----------LTDPSINESL--KTAMSRISEKD-------------------------I 641

  Fly   446 SLAAMNGNHECIDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRTKPEYSPGEYSPGNILIIL 510
            ....:..      :||..:..|          ||                        |.:|:.|
Worm   642 PFGVIEA------ILNDIASRG----------VD------------------------GAVLVFL 666

  Fly   511 PTYYHIVKLNYMILSHCLTGSLQECSIFLLYDNMRNDYLQALVNASDETVKVVLATDIIESLCLK 575
            |.:..|:.|...:|.|...|...:..|..|:..:.:...:.:.|......|::::|:|.|:
Worm   667 PGWAEIMTLCNRLLEHQEFGQANKYEILPLHSQLTSQEQRKVFNHYPGKRKIIVSTNIAET---- 727

  Fly   576 VPFKYQIDTACRLNNVYDTTSCSGDDRF------------EWVAKDALLRRELILQPNKGDVQ-- 626
               ...||..     ||...||...:|.            .|.:|..:::|    :...|.|:
Worm   728 ---SITIDDV-----VYVIDSCKAKERMYTSNNNMVHFATVWASKTNVIQR----RGRAGRVRAG 780

  Fly   627 -CFRLISKEAYEELSETSQPSLQTMQLDKICLAVKLLSPNTIISEYLGITISPPPLINVHHAVQF 690
             .|.|.||..:|.|.:.....:..:.|.:|.|.:|||...: :.|:||..:.|||...|..:...
Worm   781 YAFHLCSKMRFEALDDHGTAEMLRIPLHQIALTIKLLRLGS-VGEFLGKALQPPPYDMVVESEAV 844

  Fly   691 LKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPFTED 755
            |:.:..||...::|.||..|..:|:...:.::||.|..|.....:..:.|::|...|. :|..:.
Worm   845 LQAMGALDRNLELTSLGKMLARMPIEPVIAKVLILGTALGAGSVMCDVASAMSFPTPF-VPREKH 908

  Fly   756 IDNLWDRFTIYIQNSIKKERTYLSDNQFSDHFIFVRLY---------------KEWQNRMHNRTP 805
                        .:.:...:...:.|:||||...|.:.               :|:..|.....|
Worm   909 ------------HSRLSGTQRKFAGNKFSDHVAIVSVIQGYREAVQMGASAAEREFCERYSLSNP 961

  Fly   806 PLYLKDEYEFMLNGLMEQLTSIRSEIVSSLRAANLIHSRGKLSMNNLNQMSCNWHMVKAALTGGM 870
            .|.:.|.....|..::....|...:|:..:..             |:|......:::::.|...:
Worm   962 VLKMTDGARRQLIDVLRNQCSFPEDILFDISV-------------NVNGPDRELNLMRSLLVMAL 1013

  Fly   871 YPNI-YAVDTRK-------SSLKSAFSGNVSMHPNTVLRDFLEPLNISAQSFRTPWIVCNRQKSH 927
            |||: |.|..||       |:|.:.:|..|.|: |....||..||.:..:..||..|.| :|.|.
Worm  1014 YPNVAYYVGKRKVLTIEQSSALINKYSMLVPMN-NRQEMDFPSPLLVFTEKVRTRCISC-KQMSV 1076

  Fly   928 IVYATLVVPLAVAMFSGHPRIRLSPICDSEMSLTDRNVNVFIDEWIWMVMSKATAEMVMRTRYYF 992
            |....|:|       .|..::.    |..|..       |.|||.|.:.|:.:||..::.
Worm  1077 ISAIQLLV-------FGSRKVE----CVGEGL-------VRIDETITIRMNVSTAAALIG----- 1118

  Fly   993 FKMYHDLLKHCSELDMWRRDCEPVSQYT-----------VLTDTLSKIFESEDGFVGFFKPPPIT 1046
                   |:.|.|. :..:.||......           :|.|..|:.|.||.|        ||
Worm  1119 -------LRPCIEA-LLVKSCENPESLAGLNPSDAELRQLLRDISSEEFMSEAG--------PI- 1166

  Fly  1047 FLPTPQLPSLYLLSVNA------------HFSWAREVEENMLSKPHHFNSHFIERQFFVLYAGGD 1099
                    ...||:.||            :..|.          |.:.||.| :.|.|...|||.
Worm  1167 --------KDSLLTDNALIQKGPAPNRLEYADWG----------PSNNNSSF-QNQDFPPAAGGK 1212

  Fly  1100 CEEF--HSRNTPAFIESVLGKFVRPIDTPN 1127
            ...:  :.|....:.::      ||...||
Worm  1213 VHPYRGNRRGNHPYAQN------RPYAPPN 1236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	6/31 (19%)
		ANK	407..>460	CDD:238125	6/52 (12%)
		Ank_2	413..>460	CDD:289560	3/46 (7%)
		HrpA	<484..973	CDD:224557	113/526 (21%)
		HA2	694..763	CDD:214852	15/68 (22%)
		OB_NTP_bind	823..945	CDD:285018	31/129 (24%)
rha-1	NP_495890.2	DSRM	6..71	CDD:214634
		DSRM	173..243	CDD:214634
		HrpA	337..>974	CDD:224557	164/791 (21%)
		DEXDc	398..539	CDD:238005	40/141 (28%)
		Helicase_C	649..739	CDD:278689	25/135 (19%)
		HA2	847..931	CDD:214852	20/96 (21%)
		OB_NTP_bind	971..1086	CDD:285018	32/136 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810