DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and mog-5

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_495019.1	Gene:	mog-5 / 173920	WormBaseID:	WBGene00003393	Length:	1200	Species:	Caenorhabditis elegans

Alignment Length:	778	Identity:	154/778 - (19%)
Similarity:	268/778 - (34%)	Gaps:	272/778 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 KIMCIERQAILATYNSQRTANFFGEQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLRS-LTSQQF 260
            ||.|.:.:.:.|...::|.|..:|.:||..||..:.:....|..|.|.|.|....||. |.....
Worm   587 KIGCTQPRRVAAMSVAKRVAEEYGCKLGTDVGYTIRFEDCTSQDTIIKYMTDGMLLRECLIDPDL 651

  Fly   261 RNISHLVVNDVHLHDPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFGEG--------- 316
            ...|.:::::.|....:||:|...::.|......|::::.|...:..||:::|.|.
Worm   652 SGYSLIMLDEAHERTIHTDVLFGLLKAAARKRPELKLIITSATLDSVKFSEYFLEAPIFTIPGRT 716

  Fly   317 --LQLNMIKQPEVAPRVSYLNELHSCIALAGIHKGPDIYKEIPEAFRANNPRNEQMDKCLQAYGE 379
              :::...::||    ..||...|  |.:..||              ...|
Worm   717 FPVEILYTREPE----SDYLEAAH--ITVMQIH--------------LTEP-------------- 747

  Fly   380 LGTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNA 444
                               |.:....|||:..:..:.|:                    |:::
Worm   748 -------------------PGDVLVFLTGQEEIDTSCEV--------------------LYER-- 771

  Fly   445 ISLAAMNGNHECIDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRTKPEYSPGEYSPGNILII 509
                                     :||..||.                ||           |||
Worm   772 -------------------------MKSMGPDV----------------PE-----------LII 784

  Fly   510 LPTYYHIVKLNYMILSHCLTGSLQECSIFLLYDNMRNDYLQALVNASDETVKVVLATDIIE-SLC 573
            ||.|                |:|.......::|           .|.....|||:||:|.| ||.
Worm   785 LPVY----------------GALPSEMQTRIFD-----------PAPAGKRKVVIATNIAETSLT 822

  Fly   574 LKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLRRELILQP--------------NKGD 624
            :...| |.:|.......:|:..  ||.|             .|::.|              ..|.
Worm   823 IDGIF-YVVDPGFVKQKIYNPK--SGMD-------------SLVVTPISQAAAKQRSGRAGRTGP 871

  Fly   625 VQCFRLISKEAY-EELSETSQPSLQTMQLDKICLAVKLLSPNTIIS-EYLGITISPPPLINVHHA 687
            .:|:||.::.|: :|:..|..|.:|...|....|.:|.:..|.:|. :::    ..|||.::..|
Worm   872 GKCYRLYTERAFRDEMLPTPVPEIQRTNLASTLLQLKAMGINNLIDFDFM----DAPPLDSMITA 932

  Fly   688 VQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPF 752
            :..|..:..||....:|.||.|:.:.|:...|.::||..:.|.|.:.:||||:.|
Worm   933 LNTLHTLSALDGDGLLTKLGRRMAEFPLEPSLSKLLIMSVDLGCSEEVLTIVAML---------- 987

  Fly   753 TEDIDNLWDRFTIYIQNSIKKERTYLSDNQFS-------DHFIFVRLYKEWQNRMHNRTPPLYLK 810
              ::.|::.|         .||:...:|.:.:       ||...:.:|..|:|  |:.:.|...:
Worm   988 --NVQNIFYR---------PKEKQDHADQKKAKFHQPEGDHLTLLAVYNSWKN--HHFSQPWCFE 1039

  Fly   811 DEYEFMLNGLMEQLTSIRSEIVSSLRAANLIHSRGKLSMNNLNQMSCNWHM--VKAALTGGMYPN 873
            :   |:....|::...||.:::.       |..|.||.|     :||...:  |:.|:..|.:.|
Worm  1040 N---FIQVRSMKRAQDIRKQLLG-------IMDRHKLLM-----VSCGRDVSRVQKAICSGFFRN 1089

  Fly   874 IYAVDTRKSSLKSAFSGNVSMHPNTVLRDFLEPLNISAQSFRTPWIVC-NRQKSHIVYATLVV 935
            ....|.::.........||.:||::                     .| .:|...:||..||:
Worm  1090 AAKRDPQEGYRTLTDGQNVYIHPSS---------------------ACFQQQPEWVVYHELVM 1131

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	4/31 (13%)
		ANK	407..>460	CDD:238125	4/52 (8%)
		Ank_2	413..>460	CDD:289560	2/46 (4%)
		HrpA	<484..973	CDD:224557	104/479 (22%)
		HA2	694..763	CDD:214852	18/68 (26%)
		OB_NTP_bind	823..945	CDD:285018	24/116 (21%)
mog-5	NP_495019.1	S1_DHX8_helicase	234..311	CDD:240189
		DEXDc	534..721	CDD:214692	31/133 (23%)
		DEXDc	557..695	CDD:238005	27/107 (25%)
		HELICc	766..870	CDD:197757	36/220 (16%)
		HA2	939..1021	CDD:214852	24/102 (24%)
		OB_NTP_bind	1055..1154	CDD:285018	22/110 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810