DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and DHX8

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_004932.1	Gene:	DHX8 / 1659	HGNCID:	2749	Length:	1220	Species:	Homo sapiens

Alignment Length:	928	Identity:	180/928 - (19%)
Similarity:	323/928 - (34%)	Gaps:	299/928 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 PKTLVLSSGATLNMFTLLSRKSLMGKEDLELYADLVSMKANASDLP---SLHL--PLP------- 127
            |..:|.:...:|:...::  :|.:.||..||  .....:|....:|   :.|.  |||
Human   461 PIKIVKNPDGSLSQAAMM--QSALAKERREL--KQAQREAEMDSIPMGLNKHWVDPLPDAEGRQI 521

  Fly   128 -------AIRPPNLRFWTEAQLNFLTAFLG----------------HSLSDEILQSLYASRVIVY 169
                   .:.|.::..|.:.......|..|                :.|.::::|:::.:::::.
Human   522 AANMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIV 586

  Fly   170 NAALCWDKSVFLPLVILDDCRNKKSNVKIMCIERQAILATYNSQRTANFFGEQLGETVGIQLPYF 234
            .......|:..:...:.:  ....|..||.|.:.:.:.|...::|.:..||..||:.||..:.:.
Human   587 IGETGSGKTTQITQYLAE--AGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFE 649

  Fly   235 SAVSSSTFIIYSTAQYFLRS-LTSQQFRNISHLVVNDVHLHDPYTDILLSEIRMALSSHQNLRVV 298
            ...|..|.|.|.|....||. |........:.:::::.|....:||:|...::..:...|:::::
Human   650 DCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLI 714

  Fly   299 LLSQMGNPKKFTDFFGEG-----------LQLNMIKQPEVAPRVSYLNELHSCIALAGIHKGPDI 352
            :.|...:..||:.:|.|.           :::...|:||    ..||:.  |.|.:..||
Human   715 VTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPE----TDYLDA--SLITVMQIH----- 768

  Fly   353 YKEIPEAFRANNPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASE 417
                     ...|                                 |.:....|||:..:..|.|
Human   769 ---------LTEP---------------------------------PGDILVFLTGQEEIDTACE 791

  Fly   418 LNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVKSAKPDFVDYDL 482
            :                    |:::                           :||..||.
Human   792 I--------------------LYER---------------------------MKSLGPDV----- 804

  Fly   483 IIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHCLTGSLQECSIFLLYDNMRND 547
                       ||           |||||.|            ..|...:|.    .::|
Human   805 -----------PE-----------LIILPVY------------SALPSEMQT----RIFD----- 826

  Fly   548 YLQALVNASDETVKVVLATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALL 612
                  .|...:.|||:||:|.|:........|.:|.......||:  |.:|.|
Human   827 ------PAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYN--SKTGID----------- 872

  Fly   613 RRELILQP--------------NKGDVQCFRLISKEAY-EELSETSQPSLQTMQLDKICLAVKLL 662
              :|::.|              ..|..:|:||.::.|| :|:..|:.|.:|...|....|::|.:
Human   873 --QLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAM 935

  Fly   663 SPNTIIS-EYLGITISPPPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFG 726
            ..|.::| :::    ..||:..:..|::.|..:..|||...:|.||.|:.:.|:...|.:|||..
Human   936 GINDLLSFDFM----DAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMS 996

  Fly   727 ILLRCLDPILTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKKERTYLSDNQFSDHFIFVR 791
            :.|.|.:.:|||||.||..:....|  :|...|.|:         ||.:.:.::   .||...:.
Human   997 VHLGCSEEMLTIVSMLSVQNVFYRP--KDKQALADQ---------KKAKFHQTE---GDHLTLLA 1047

  Fly   792 LYKEWQNRMHNRTPPLYLKDEYEFMLNGLMEQLTSIRSEIVSSLRAANLIHSR--GKLSMNNLNQ 854
            :|..|:|...: .|..|             |.....|     |||.|..|..:  |.:..:.|:.
Human  1048 VYNSWKNNKFS-NPWCY-------------ENFIQAR-----SLRRAQDIRKQMLGIMDRHKLDV 1093

  Fly   855 MSCNWHMVKA--ALTGGMYPNIYAVDTRKSSLKSAFSGNVSMHPNTVLRDFLEPLNISAQSFRTP 917
            :||....|:.  |:..|.:.|....|.::..........|.:||::.|
Human  1094 VSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSAL----------------- 1141

  Fly   918 WIVCNRQKSHIVYATLVV 935
               .|||...:||..||:
Human  1142 ---FNRQPEWVVYHELVL 1156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	5/31 (16%)
		ANK	407..>460	CDD:238125	5/52 (10%)
		Ank_2	413..>460	CDD:289560	3/46 (7%)
		HrpA	<484..973	CDD:224557	108/472 (23%)
		HA2	694..763	CDD:214852	25/68 (37%)
		OB_NTP_bind	823..945	CDD:285018	26/117 (22%)
DHX8	NP_004932.1	GH2-like_DHX8	25..92	CDD:409668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..266
		RpsA	<263..422	CDD:223613
		S1_DHX8_helicase	265..343	CDD:240189
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..372
		HrpA	557..1219	CDD:224557	162/828 (20%)
		DEAH box	685..688		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810