DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bgcn and Dhx15

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_031865.2	Gene:	Dhx15 / 13204	MGIID:	1099786	Length:	795	Species:	Mus musculus

Alignment Length:	785	Identity:	137/785 - (17%)
Similarity:	256/785 - (32%)	Gaps:	263/785 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 IMCIERQAILATYNSQRTANFFGEQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLR-SLTSQQFR 261
            :.|.:.:.:.|...:||.|:.....||:.||..:.:....|:.|.:.|.|....|| ::......
Mouse   188 VACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLE 252

  Fly   262 NISHLVVNDVHLHDPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFGEGLQLNMIKQPE 326
            ....:::::.|.....||||:..::..:....:|:|:::|...:..||..:|            :
Mouse   253 RYGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYF------------D 305

  Fly   327 VAPRVSYLNELHSCIALAGIHKGPDIYKEIPEAFRANNPRNEQMDKCLQAYGELGTDAALRPFLY 391
            ..|.::.....|..                 |.|....|..:.:            :||:|..:
Mouse   306 NCPLLTIPGRTHPV-----------------EIFYTPEPERDYL------------EAAIRTVI- 340

  Fly   392 AVNYDLAPVNYRHSLTGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHEC 456
                               .:|...|    ....||||         |..|..|..|......|.
Mouse   341 -------------------QIHMCEE----EEGDLLLF---------LTGQEEIDEACKRIKREV 373

  Fly   457 IDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRTKP--------EYSPGEYSPGNILIILPTY 513
            .|:              .|:..|    |.|:.|..|.|        |..|.:...|.|
Mouse   374 DDL--------------GPEVGD----IKIIPLYSTLPPQQQQRIFEPPPPKKQNGAI------- 413

  Fly   514 YHIVKLNYMILSHCLTGSLQECSIFLLYDNMRNDYLQALVNASDETVKVVLATDIIESLCLKVPF 578
                            |.                             |||::|:|.|:.......
Mouse   414 ----------------GR-----------------------------KVVVSTNIAETSLTIDGV 433

  Fly   579 KYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLR--------RELILQPNKGDVQCFRLISKEA 635
            .:.||.......||:...     |.|.:...|:.:        |....:|.|    ||||.:::|
Mouse   434 VFVIDPGFAKQKVYNPRI-----RVESLLVTAISKASAQQRAGRAGRTRPGK----CFRLYTEKA 489

  Fly   636 YE-ELSETSQPSLQTMQLDKICLAVKLLSPNTIIS-EYLGITISPPPLINVHHAVQFLKKIDVLD 698
            |: |:.:.:.|.:....|..:.|.:|.|..:.::. :::    .||....:..|::.|..:..|:
Mouse   490 YKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDFM----DPPAPETLMRALELLNYLAALN 550

  Fly   699 DAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPFTEDIDNLWDRF 763
            |..|:|.||..:.:.|:..||.:|:|......|.:.:|:|.:.||      :|
Mouse   551 DDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCSNEVLSITAMLS------VP------------ 597

  Fly   764 TIYIQNSIKKERTYLSDNQFS----DHFIFVRLYKEWQNRMHNRTPPLYLKDEYEFMLNGLMEQL 824
            ..:::.:..|:....:..:|:    ||...:.:|..::.. |......|
Mouse   598 QCFVRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQN-HESVQWCY---------------- 645

  Fly   825 TSIRSEIVSSLRAANLIHSRGKLSMNNLNQM------------------SCNWHM-VKAALTGGM 870
                         .|.|:.|..:|.:|:.|.                  |.:::: ::.||..|.
Mouse   646 -------------DNFINYRSLMSADNVRQQLSRIMDRFNLPRRSTDFTSRDYYINIRKALVTGY 697

  Fly   871 YPNIYAVDTRKSSLKSAFSGNVSMHPNTVLRDFLEPLNISAQSFRTPWIVCNR----QKSHIVYA 931
            :..:..::.....|....:..|.:||:|||            ..:..|::.|.    .|::|...
Mouse   698 FMQVAHLERTGHYLTVKDNQVVQLHPSTVL------------DHKPEWVLYNEFVLTTKNYIRTC 750

  Fly   932 TLVVP 936
            |.:.|
Mouse   751 TDIKP 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	6/31 (19%)
		ANK	407..>460	CDD:238125	12/52 (23%)
		Ank_2	413..>460	CDD:289560	12/46 (26%)
		HrpA	<484..973	CDD:224557	89/498 (18%)
		HA2	694..763	CDD:214852	17/68 (25%)
		OB_NTP_bind	823..945	CDD:285018	23/137 (17%)
Dhx15	NP_031865.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..111
		HrpA	124..763	CDD:224557	137/785 (17%)
		DEAH box	260..263		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810