Protein Alignment bgcn and TDRD9

DIOPT Version :10

• Sequence 1: NP_523832.2
• Gene: bgcn / 47873
• FlyBaseID: FBgn0004581
• Length: 1215
• Species: Drosophila melanogaster
• Sequence 2: NP_694591.2
• Gene: TDRD9 / 122402
• HGNCID: 20122
• Length: 1382
• Species: Homo sapiens
• Alignment Length: 1075
• Identity: 214/1075 - (19%)
• Similarity: 385/1075 - (35%)
• Gaps: 303/1075 - (28%)

  Fly   127 PAIRPPNLRFWTEAQLNFLTAFLGHS----------LSDEILQSLYASRVIVYNAALCWDKSVFL 181
            |..||      :.|:|:.:|...|.:          ..:|::..:.::.|::.:.|....||..|
Human   107 PGPRP------SLAKLSSVTCIPGTTYKYPDLPISRYKEEVVSLIESNSVVIIHGATGSGKSTQL 165

  Fly   182 PLVILDDCRNKKSNVKIMCIERQAI----LATYNSQRTANFFGEQLGETVGIQLPYFSAVSSSTF 242
            |..|||....:.:...|:..:.:.|    :|.:.|:..|...|..:|..||::    ...:..|.
Human   166 PQYILDHYVQRSAYCSIVVTQPRKIGASSIARWISKERAWTLGGVVGYQVGLE----KIATEDTR 226

  Fly   243 IIYSTAQYFLRSLTS-QQFRNISHLVVNDVHLHDPYTDILLSEIRMALSSHQN-LRVVLLSQMGN 305
            :||.|....|:.:.| :.....:|:::::||......|.||..:|..|.::.. ::|||:|...:
Human   227 LIYMTTGVLLQKIVSAKSLMEFTHIIIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATIS 291

  Fly   306 PKKFTDFFGEGLQLNMIKQPEVAPRVSYLNELHSCIALAGIHKGPDIYKEIPEAFRANNPRNEQM 370
            .|:|.|:|...:|..|                                          ||
Human   292 CKEFADYFAVPVQNKM------------------------------------------NP----- 309

  Fly   371 DKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNKANHLRLLLFMGADPY 435
                               .|....:..|    ||:    ..::.::|...:|.:|...:..:|.
Human   310 -------------------AYIFEVEGKP----HSV----EEYYLNDLEHIHHSKLSPHLLEEPV 347

  Fly   436 IVDLFQQNAISLAAM--------NGNHECIDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRT 492
            |.....:.|:||..|        :||       .::|...:|::.:
Human   348 ITKDIYEVAVSLIQMFDDLDMKESGN-------KAWSGAQFVLERS------------------- 386

  Fly   493 KPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHCLTGSL--QECSIFLLY-----DNMRNDYLQ 550
                        ::|:.||   .:.::|||   |.|..||  :...::.|:     :...|.:|.
Human   387 ------------SVLVFLP---GLGEINYM---HELLTSLVHKRLQVYPLHSSVALEEQNNVFLS 433

  Fly   551 ALVNASDETVKVVLATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLRRE 615
            .:....    |::|:|:|.||.......||.||.......|.|..:.....|..|.:|.:..:|
Human   434 PVPGYR----KIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCNQR- 493

  Fly   616 LILQPNKGDVQ---CFRLISKEAYE-ELSETSQPSLQTMQLDKICLAVKLL---SPNTIISEYLG 673
               :...|.|.   |:||:.|:.:: .:.:...|.:....|....|.||||   .|..:    |.
Human   494 ---KGRAGRVSRGYCYRLVHKDFWDNSIPDHVVPEMLRCPLGSTILKVKLLDMGEPRAL----LA 551

  Fly   674 ITISPPPLINVHHAVQFLKKIDVL------DDAE----DVTWLGCRLMDIPVSCQLGRMLIFGIL 728
            ..:|||.|.::...:..||::..|      :|..    ::|:||..|..:||:.|||::::.|.:
Human   552 TALSPPGLSDIERTILLLKEVGALAVSGQREDENPHDGELTFLGRVLAQLPVNQQLGKLIVLGHV 616

  Fly   729 LRCLDPILTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKKERTYLSDNQFSDHFIFVRLY 793
            ..|||..|.|.::||..:...:||.:.:|..             :.:...|.:..||....|..:
Human   617 FGCLDECLIIAAALSLKNFFAMPFRQHLDGY-------------RNKVNFSGSSKSDCIALVEAF 668

  Fly   794 KEWQNRMHNRTPPL-YLKDEYEF-MLNGL----MEQLTSIRSEIVSSLRAANLIHSRGKLSMNNL 852
            |.|  :...:|..| |.|||..: .||.:    :.::..:..|:.:.:...|: |...:..:.:.
Human   669 KTW--KACRQTGELRYPKDELNWGRLNYIQIKRIREVAELYEELKTRISQFNM-HVDSRRPVMDQ 730

  Fly   853 NQMSCNWHMVKAALTGGMYPNIYAVDTRKSSLKSAFSGNVSMHP-NTVLRDFLEPLNI----SAQ 912
            ..:.....:::..|.|..|||.:........:  |........| .||:...:.|...    ..|
Human   731 EYIYKQRFILQVVLAGAFYPNYFTFGQPDEEM--AVRELAGKDPKTTVVLKHIPPYGFLYYKQLQ 793

  Fly   913 S-FRTPWIVCNRQKSHIVYATLVVPLAVAMFSGHPRIRLSPICDSEMSLTDRNVNVFIDEWIWMV 976
            | ||.    |.:.|| ||:..   ..|...||.:|..|...:....|::....:.|.::
Human   794 SLFRQ----CGQVKS-IVFDG---AKAFVEFSRNPTERFKTLPAVYMAIKMSQLKVSLE------ 844

  Fly   977 MSKATAEMV------------MRTRYYFFKMYHDLLKHCSELDMWRRDCEPV-------SQYTVL 1022
            :|..:||.:            ..||.              .:|..::..:|:       .:...:
Human   845 LSVHSAEEIEGKVQGMNVSKLRNTRV--------------NVDFQKQTVDPMQVSFNTSDRSQTV 895

  Fly  1023 TDTLSKIFESEDGFVGFF--------------------KPPPITFLPTPQLPSLYLLSVNAHFSW 1067
            ||.|..|..:|...||.|                    ....:..|||...|.|..|:..|.|
Human   896 TDLLLTIDVTEVVEVGHFWGYRIDENNSEILKKLTAEINQLTLVPLPTHPHPDLVCLAPFADF-- 958

  Fly  1068 AREVEENMLSKPHHFNSHFIERQFFVLYAGGDCEE 1102
                     .|..:|.:.       |||..|:..|
Human   959 ---------DKQRYFRAQ-------VLYVSGNSAE 977

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	DEAD-like_helicase_N	155..314	CDD:475120	40/164 (24%)
		ANKYR	<398..>460	CDD:440430	14/69 (20%)
		ANK repeat	406..438	CDD:293786	5/31 (16%)
		P-loop containing Nucleoside Triphosphate Hydrolases	465..>594	CDD:476819	25/135 (19%)
		HA2	687..789	CDD:461295	27/111 (24%)
		OB_NTP_bind	862..945	CDD:400182	22/88 (25%)
TDRD9	NP_694591.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..62
		HrpA	130..>716	CDD:441249	149/734 (20%)
		DEXHc_TDRD9	132..315	CDD:350746	46/252 (18%)
		DEAH box. /evidence=ECO:0000250|UniProtKB:Q14BI7	254..257		0/2 (0%)
		Tudor_TDRD9	905..1005	CDD:410502	19/91 (21%)