DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and Dhx57

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_001157231.1	Gene:	Dhx57 / 106794	MGIID:	2147067	Length:	1388	Species:	Mus musculus

Alignment Length:	1039	Identity:	216/1039 - (20%)
Similarity:	392/1039 - (37%)	Gaps:	254/1039 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 VNGNSCVKVYKQACRHYLEEPKTLVLSSGATLNMFTLLSRKSLMGKEDLELYADLVSMKANASDL 119
            |...|.|.:.|::.:.|....|:|...:       :.:.|:..|.:...:.:|.|...:.
Mouse   492 VENESYVNLKKRSYKRYDRPAKSLFAEN-------SKICRQFQMKQASRQFHAILQERQL----- 544

  Fly   120 PSLHLPLPAIRPPNLRFWTEAQLNFLTAFLGHSLSDEILQSLYASRVIVYNAALCWDKSVFLPLV 184
                  |||        |.|              .:.||:.|...:|:|.:......|:..:|..
Mouse   545 ------LPA--------WEE--------------RETILKLLSKHQVVVISGMTGCGKTTQIPQF 581

  Fly   185 ILDDCRN--KKSNVKIMCIERQAILATYNSQRTANFFGEQLGETVGIQLPYFSAVSSSTFIIYST 247
            |||:..|  .:....|:|.:.:.|.|...::|.|....|::|.|||.|:...|..||:|.::|.|
Mouse   582 ILDNSLNGPPERVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESVKSSATRLLYCT 646

  Fly   248 AQYFLRSLTSQ-QFRNISHLVVNDVHLHDPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTD 311
            ....||.|... ..:.::|::|::||.....:|.||..::..:.....|:|:|:|...:...|:.
Mouse   647 TGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSATLDAGLFSK 711

  Fly   312 FFG--------------------EGLQLNMIKQPEVAPRVSYLNELHSCIALAGIHKGPDIYKEI 356
            :|.                    :.|.:......:.:|   |:..:            ..|.||.
Mouse   712 YFSYCPVITIPGRAFPVDQFFLEDALAVTRYVLQDGSP---YMRSM------------KQIAKEK 761

  Fly   357 PEAFRANNPRNEQMDKCLQAYGEL-GTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFAS--EL 418
            .:| |.|....|::::.|:....| ..:.:::..:.....|...:..|:....|:.:...|  :.
Mouse   762 LKA-RHNRTAQEEVEEDLRLSLHLQDEEESVKDTIPDQQLDFKQLLIRYKGVSKSVIKTMSVMDF 825

  Fly   419 NKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVKSAKPDFVDYDLI 483
            .|.|   |.|......:|||             |.|
Mouse   826 EKVN---LELIEALLEWIVD-------------GKH----------------------------- 845

  Fly   484 IDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHCLTGSLQ--ECSIFLLYDNMRN 546
                            .|.||.:|:.||....|..|...:.|:.|..:.:  .|.|..|:.::.:
Mouse   846 ----------------AYPPGAVLVFLPGLAEIKMLYEQLQSNSLFNNRRSHRCVIHPLHSSLSS 894

  Fly   547 DYLQAL-VNASDETVKVVLATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDA 610
            :..||: |.......|::::|:|.|:........|.||:.......||  :..|.:..|    |.
Mouse   895 EEQQAVFVKPPMGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYD--AGKGMESLE----DT 953

  Fly   611 LLRRELILQPNKGDV------QCFRLISKEAY-EELSETSQPSLQTMQLDKICLAVKLL---SPN 665
            .:.:...|| .||..      .||.|.:...| .:|.:...|.:|.:.|:::||.:|:|   |.:
Mouse   954 FVSQANALQ-RKGRAGRVASGVCFHLFTSHHYNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSTH 1017

  Fly   666 TIISEYLGITISPPPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLR 730
            .:.|.:..: |.||.:.::..:...|:.:..|...|.:|.||..|..:||..::|::::.|.:.|
Mouse  1018 NLQSVFSRL-IEPPHIDSLRASKVRLRDLGALTPDEKLTPLGYHLASLPVDVRIGKLMLLGSIFR 1081

  Fly   731 CLDPILTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKKERTYLSDNQF----SDHFIFVR 791
            ||||.|||.:||:...|...|        ||          |||.......:|    ||:...:.
Mouse  1082 CLDPALTIAASLAFKSPFVSP--------WD----------KKEEANQKKLEFAFANSDYLALLC 1128

  Fly   792 LYKEWQNRMHNRTPPLYLKDEYEFMLNGLMEQLTSIR---SEIVS-------SLRAANL------ 840
            .||.||..........|......|:....::::.|::   :|::|       .|||..:
Mouse  1129 AYKGWQLSTKESARASYNYCRQNFLSGRTLQEMASLKRQFTELLSDIGFVKEGLRAKEIEKRAQG 1193

  Fly   841 ----IHSRGKLSMNNLNQMSCNWHMVKAALTGGMYPNIYAVDTRKSSLKSAFSGNVSMHPNTVLR 901
                :.:.|:.:..|..    |..::.|.|...:|||:..|.|.:...:...||.|.:.|.:...
Mouse  1194 GDGVLDATGEEANTNAE----NPKLISAVLCAALYPNVVQVKTPEGKFQKTSSGVVRLQPKSAEL 1254

  Fly   902 DFL-----------EPLNISAQSFRTPWIVCNRQ-KSHIVY---ATLVVPLAVAMFSGHPRIRLS 951
            .|:           ..:|...:.|.:|:::.:.: |:..|:   .::|....:.:|.|
Mouse  1255 KFVTKNDGYVHIHPSSVNYQVRHFDSPYLLYHEKIKTSRVFIRDCSMVSVYPLVLFGG------- 1312

  Fly   952 PICDSEMSLTDRNVNV------FI----DEWI-WMVMSKATAEMVMRTRYYFFKMYHDLLKHCS 1004
                       ..|||      |:    |.|| ::..|...||:|...|....::..|.:|:.|
Mouse  1313 -----------GQVNVQLQRGAFVVSLDDGWIRFVAASHQVAELVKELRCELDQLLQDKIKNPS 1365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	7/33 (21%)
		ANK	407..>460	CDD:238125	11/54 (20%)
		Ank_2	413..>460	CDD:289560	10/48 (21%)
		HrpA	<484..973	CDD:224557	120/550 (22%)
		HA2	694..763	CDD:214852	24/68 (35%)
		OB_NTP_bind	823..945	CDD:285018	28/156 (18%)
Dhx57	NP_001157231.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..154
		UBA_DHX57	181..218	CDD:270502
		RWD	246..419	CDD:368608
		HrpA	501..1298	CDD:224557	195/943 (21%)
		DEVH box	669..672		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810