DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and Dhx29

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	XP_002729053.2	Gene:	Dhx29 / 100362324	RGDID:	2318361	Length:	1366	Species:	Rattus norvegicus

Alignment Length:	979	Identity:	222/979 - (22%)
Similarity:	366/979 - (37%)	Gaps:	292/979 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 LSRKSL--MGKEDLE----LYADLVSMKANASDLPSLHLPLPAIRPPNLRFWTEAQLNFLTAFLG 150
            ||..||  .|.||||    |:..|.|                  .|...|...|.|.  |..| .
  Rat   533 LSALSLEPTGAEDLEPVRNLFRRLQS------------------TPKYQRLLKERQQ--LPVF-K 576

  Fly   151 HSLSDEILQSLYASRVIVYNAALCWDKSVFLPL-----VILDDCRNKKSNVKIMCIERQAILATY 210
            |..|  |:::|...||:|........||..:|.     ::|:||..:|.|  |:|.:.:.|.|..
  Rat   577 HRAS--IVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNDCGARKCN--IVCTQPRRISAVS 637

  Fly   211 NSQRTANFFGEQLG---------ETVGIQLPYFSAVSSSTFIIYSTAQYFLRSLTSQ-QFRNISH 265
            .:.|..    |:||         ...|.|:...|..|.||.::|.|....||.|... ...::||
  Rat   638 LATRVC----EELGCEGGPGGRNSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSH 698

  Fly   266 LVVNDVHLHDPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFF---------GEGLQLNM 321
            ::|::||.....:|.||..::..|....:|.::|:|...:..||:.:|         |....:.:
  Rat   699 VIVDEVHERSVQSDFLLVILKEILQKRSDLHLILMSATVDSDKFSTYFTHCPILRISGRSYPVEV 763

  Fly   322 IKQPEVAPRVSYLNELHSCIALAGIHKGPDIYKEIPEAFRANNPRNEQMDKCLQAYGELGTDAAL 386
            ....::.....::.|..|                            |...|.|:...|:
  Rat   764 FHLEDIVEETGFILEKDS----------------------------EYCQKFLEEEEEI------ 794

  Fly   387 RPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMN 451
                 .:|           :|.|     |..:.|.... :.:..||.|.:...:|:.:
  Rat   795 -----TIN-----------VTSK-----AGGIKKYQEC-IPVQSGASPELSPFYQKYS------- 830

  Fly   452 GNHECIDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHI 516
                        |...|.|....|..::.|||::::..|...|::...|   |.:||.||...||
  Rat   831 ------------SRTQYAVLYMNPHKINLDLILELLVYLDKSPQFRNIE---GAVLIFLPGLAHI 880

  Fly   517 VKLNYMILSHCLTGSLQECSIFLLYDNMRND-----------YLQALVNASDETV---------- 560
            .:                     |||.:.||           .|.::::..|:..
  Rat   881 QQ---------------------LYDLLSNDRRFYSERYQLIALHSVLSTQDQAAAFMLPPPGVR 924

  Fly   561 KVVLATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLRRELILQPNKGDV 625
            |:||||:|.|:........:.|||.....|.|..:|........:|:|.:.|:|    |...|.|
  Rat   925 KIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETFVSKASALQR----QGRAGRV 985

  Fly   626 Q---CFRLISKEAYEELSETSQPSLQTMQLDKICLAV---KLLSPNTIISEYLGITISPPPLINV 684
            :   ||||.::|.:|...|.|.|.:..:.|:::||.:   .|.||    .::|...:.||....:
  Rat   986 RDGFCFRLYTRERFEGFLEYSVPEILRVPLEELCLHIMKCDLGSP----EDFLSKALDPPQPQVI 1046

  Fly   685 HHAVQFLKKIDVLDDAE-DVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPL 748
            .:|:..|:||...:.:| .:|.||..|..:||:.::|:|||||.:..||:|:.|:.:.::...|.
  Rat  1047 SNAMNLLRKIGACEPSEPKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLEPVATLAAVMTEKSPF 1111

  Fly   749 GIPF--TEDIDNLWDRFTIYIQNSIKKERTYLSDNQFSDHFIFVRLYKEW--------------- 796
            ..|.  .::.|             :.|....::|   |||......|..|
  Rat  1112 ITPIGRKDEAD-------------LAKSSLAVAD---SDHLTIYNAYLGWKKAQQEGGFRSEISY 1160

  Fly   797 -QNRMHNRTPPLYLKDEYEFMLNGLMEQLTSIRSEIVSSLRAANLIHS---RGK-----LSMNNL 852
             |....|||..|.|:|               ::.|::..:|||....|   .||     ||..::
  Rat  1161 CQRNFLNRTSLLTLED---------------VKQELMKLVRAAGFSSSTSWEGKKGPQALSFQDI 1210

  Fly   853 NQMSCNWHMVKAALTGGMYPNIYAVDTRKS--------SLKSAFSGNVSMHPNTVLRDFLEPLNI 909
                   .::||.|..|:|.::..:...||        .:.....|...:||::|.||.
  Rat  1211 -------ALLKAVLAAGLYDSVGKIMCTKSVDVTEKLACMVETAQGKAQVHPSSVNRDL------ 1262

  Fly   910 SAQSFRTPWIVCNRQKSHI-VY---ATLVVPLAVAMFSGHPRIRLSPICDSEMSLTDRNVNVFID 970
              |::  .|::...:..:. ||   .||:.|..|.:|.|          |.|:...:|.::|  |
  Rat  1263 --QTY--GWLLYQEKVRYARVYLRETTLITPFPVLLFGG----------DIEVQHRERLLSV--D 1311

  Fly   971 EWIW 974
            .||:
  Rat  1312 GWIY 1315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	7/31 (23%)
		ANK	407..>460	CDD:238125	8/52 (15%)
		Ank_2	413..>460	CDD:289560	6/46 (13%)
		HrpA	<484..973	CDD:224557	130/554 (23%)
		HA2	694..763	CDD:214852	21/71 (30%)
		OB_NTP_bind	823..945	CDD:285018	31/141 (22%)
Dhx29	XP_002729053.2	HrpA	531..1314	CDD:224557	220/976 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810