DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and dhx16

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_001116881.3	Gene:	dhx16 / 100127179	XenbaseID:	XB-GENE-480525	Length:	1033	Species:	Xenopus tropicalis

Alignment Length:	777	Identity:	152/777 - (19%)
Similarity:	272/777 - (35%)	Gaps:	235/777 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 EILQSLYASRVIVYNAALCWDKSVFLPLVILDDCRNKKSNVKIMCIERQAILATYNSQRTANFFG 220
            ::||::...::::........|:..:| ..|.:....|:.:||.|.:.:.:.|...|.|.:...|
Frog   399 DLLQAISDHQILIIEGETGSGKTTQIP-QYLHEHGYTKNGLKIGCTQPRRVAAMSVSARVSQEMG 462

  Fly   221 EQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLRS-LTSQQFRNISHLVVNDVHLHDPYTDILLSE 284
            .:||..||..:.:....|..|.:.|.|....||. ||.....:.|.:::::.|....:||:|...
Frog   463 VKLGNEVGYSIRFEDCTSERTVLKYMTDGMLLREFLTEPDLASYSVIIIDEAHERTLHTDVLFGL 527

  Fly   285 IRMALSSHQNLRVVLLSQMGNPKKFTDFFGEGLQLNMIKQPEVAPRVSYLNELHSCIALAGIHKG 349
            |:......|:|:|::.|...|.::|:.||
Frog   528 IKDIARFRQDLKVLVASATLNTERFSSFF------------------------------------ 556

  Fly   350 PDIYKEIPEAFRANNPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHF 414
                                                          |.||| :|  :.|:.
Frog   557 ----------------------------------------------DDAPV-FR--IPGRR---- 568

  Fly   415 ASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVKSAKPDFVD 479
                                |.||:                            |..|:.:.|:::
Frog   569 --------------------YPVDI----------------------------YYTKAPEADYLE 585

  Fly   480 YDLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHC--LTGSLQECSIFLLYD 542
             ..::.::.:..|:|        ||:||:.|.....|.....|:...|  |...:.|..:..:|.
Frog   586 -ACVVSVLQIHVTQP--------PGDILVFLTGQEEIETCCEMLQERCRRLGSKIAEMLVLPIYA 641

  Fly   543 NMRNDYLQALV--NASDETVKVVLATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEW 605
            |:.:| :||.:  .......|||:||:|.|:........|.||........|:..|.
Frog   642 NLPSD-MQAKIFEPTPPGARKVVIATNIAETSLTIDGIIYVIDPGFCKQKSYNARSG-------- 697

  Fly   606 VAKDALLRRELILQP-----------NKGDV---QCFRLISKEAYE-ELSETSQPSLQTMQLDKI 655
                   ...||:.|           ..|.|   :||||.:..||: |:.:|:.|.:|...|..:
Frog   698 -------MESLIVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYKNEMEDTTVPEIQRTNLGNV 755

  Fly   656 CLAVKLLSPNTIIS-EYLGITISPPPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQL 719
            .|.:|.|..|.:|. :::    .|||...:..|::.|..:..|:...::|.||.|:.::||...|
Frog   756 VLLLKSLGINDLIHFDFM----DPPPHETLVLALEQLYALGALNHLGELTKLGRRMAELPVDPML 816

  Fly   720 GRMLIFGILLRCLDPILTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKKERTYLSDNQFS 784
            .::::......|.:.||||.:.||            ::|     ||:.:...|......:...|:
Frog   817 SKIILASEQYGCSEQILTIAAMLS------------VNN-----TIFYRPKDKLVHADTARANFT 864

  Fly   785 ----DHFIFVRLYKEWQNRMHNRTPPLYLKDEYEFMLNGLMEQLTSIRSEIVSSLRAANLIHSR- 844
                ||.:.:.:|.:|....|:              |....|.....|     |||.|..:..:
Frog   865 VPGGDHMVLLNVYTQWVESGHS--------------LQWCYENFIQAR-----SLRRARDVREQL 910

  Fly   845 -GKLSMNNLNQMSCNWHM--VKAALTGGMYPNIYAVDTRKSSLKSAFSGN-VSMHPNTVLRD 902
             |.:....:...||....  |:.|:|.|.:  .:.....:|..|:..... |.:|||:.|.:
Frog   911 EGLMGRIEIELTSCEGDSIPVRKAITAGYF--YHTARLTRSGYKTVKQQQAVYIHPNSSLHE 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	2/31 (6%)
		ANK	407..>460	CDD:238125	4/52 (8%)
		Ank_2	413..>460	CDD:289560	3/46 (7%)
		HrpA	<484..973	CDD:224557	101/448 (23%)
		HA2	694..763	CDD:214852	16/68 (24%)
		OB_NTP_bind	823..945	CDD:285018	19/85 (22%)
dhx16	NP_001116881.3	PTZ00121	<88..381	CDD:173412
dhx16	NP_001116881.3	HrpA	356..1005	CDD:224557	152/777 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000