DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgcn and dhx37

DIOPT Version :9

Sequence 1:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	XP_005172500.1	Gene:	dhx37 / 100009635	ZFINID:	ZDB-GENE-030131-4505	Length:	1153	Species:	Danio rerio

Alignment Length:	889	Identity:	167/889 - (18%)
Similarity:	306/889 - (34%)	Gaps:	257/889 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 PSLHLP---LPAIRPPNLRF--WTEAQLNFLTAFLGHSLSDEILQSLYASRVIVYNAALCWD--- 176
            |::.:|   ||.|:...||.  ..|.|:              |::::.....:|    ||.:
Zfish   234 PAVFIPVERLPEIQEARLRLPVLAEEQI--------------IMEAVKDHECVV----LCGETGS 280

  Fly   177 -KSVFLPLVILDDCRNKKSNVKIMCIERQAILATYNSQRTANFFGEQLGETVGIQLPYFSAVSSS 240
             |:..:| ..|.:.....|...|...|.:.:.|...|.|.|.......| .|..|:.|...|:.:
Zfish   281 GKTTQVP-QFLYEAGFASSGGIIGVTEPRRVAAISMSHRVATEMNLSSG-VVSYQIRYEGNVTEN 343

  Fly   241 TFIIYSTAQYFLRSLTSQQF--RNISHLVVNDVHLHDPYTDI---LLSEIRMALSSHQNL--RVV 298
            |.|...|....|:.: .:.|  :..|.:::::.|....||||   |||.| :.|.:.:.|  :::
Zfish   344 TKIKVMTDGVLLKEI-QRDFLLQKYSVIIIDEAHERSVYTDILIGLLSRI-VPLRNKKGLPMKLI 406

  Fly   299 LLSQMGNPKKFTDFFGEGLQLNMIKQPEVAPRVSYLNELHSCIALAGIHKGPDIYKEIPEAFRAN 363
            ::|.....:.||:      ...:...|                        |.:.|.....|...
Zfish   407 IMSATLRVEDFTE------NKRLFSSP------------------------PPVIKVEARQFAVT 441

  Fly   364 ---NPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNKANHLR 425
               |.|....|...:.:.:          :..::..|.|......|||:..||     :....||
Zfish   442 VHFNKRTPMDDYTGETFRK----------ICKIHRMLPPGGILVFLTGQAEVH-----SVCRRLR 491

  Fly   426 LLLFMGADPY-----IVDLFQ------------QNAISLAAMNGNHECIDVLNSYSL----HGYV 469
                 .|.||     ..|:.:            :..:||..:|        |::||.    .|..
Zfish   492 -----KAFPYKPNREHTDMMETEEDLKKSKRAKKKNVSLPRIN--------LDNYSALPVDEGDE 543

  Fly   470 VKSAKPDFVD---YDLIIDIMYLLRTKPEYSPGEYSPGNI-LIILPTYYHIVKLNYMILSHCLTG 530
            .:.|..|..|   .||.::    |...|:....|.:..:| |.:||.|..:
Zfish   544 DRQAGIDEDDGEGSDLELE----LGDHPDTDHEEKADPSIPLYVLPLYSLL-------------- 590

  Fly   531 SLQECSIFLLYDNMRNDYLQALVNASDETVKV-----------VLATDIIESLCLKVP-FKYQID 583
                                    |.::..||           |:||::.|: .|.:| .||.:|
Zfish   591 ------------------------APEQQAKVFRPPPAGSRLCVVATNVAET-SLTIPGIKYVVD 630

  Fly   584 TACRLNNVYDTTSCSGDDRFEWVAKDALLRRELILQPNKGDVQ---CFRLISKEAYEELSETSQP 645
            ........||..:.....:..|:::.:..:|    ....|..:   |:||.|...:.:.|..|:.
Zfish   631 CGRVKKRFYDRVTGVSSFKVTWISQASANQR----AGRAGRTEPGHCYRLYSSAVFGDFSLFSEA 691

  Fly   646 SLQTMQLDKICLAVKLLSPNTIISEYLGITISPPP----LINVHHAVQFLKKIDV------LDDA 700
            .:....::.:.|.:|.|:    |.:.:......||    ||.....:..|..::.      |.:.
Zfish   692 EITRRPVEDLVLQMKDLN----IEKVVNFPFPTPPSSEALIAAEELLISLGALEKPARHGRLSEM 752

  Fly   701 E------DVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPFTEDIDNL 759
            |      .::.||..:...||:.:..:||..|....|:..|:||||:::..:     ..||.|..
Zfish   753 EKARLSCPISPLGRAMAAFPVAPRYAKMLALGRQQGCMQYIITIVSAMTVRE-----IFEDYDRP 812

  Fly   760 WDRFTIYIQNSIKKERTYLSDNQFSDHFIFVRLYKEWQNRMHNRTPPLYLKD-----------EY 813
            .......::.|.||.|:             |::.:.|.    .:...|.|.|           |:
Zfish   813 AGSEEENVKMSGKKARS-------------VQMRRLWA----GQGASLLLGDLMVLLGAVGACEF 860

  Fly   814 EFML------NGL----MEQLTSIRSEIVSSLRAANL---IHSRGKLSMNNLNQMSCNWHMVKAA 865
            ..:.      |||    |.::..:|.::.:::.|...   ::...|::.....|:.|...:|.|.
Zfish   861 AGLTPQFCEENGLRFKAMLEIRRLRGQLTNAVNAVCADADVYVDNKMAPPTEAQVLCLRQIVLAG 925

  Fly   866 LTGGMYPNIYAVDTRKSSLKSAF-----SGNVSMHPNTVLRDFL 904
            |...:...:.|.:......::|:     ...|.:||::.|...|
Zfish   926 LGDHIARRVQAEELLDPKWRNAYKTPLLDDPVFIHPSSALHKTL 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	10/36 (28%)
		ANK	407..>460	CDD:238125	13/69 (19%)
		Ank_2	413..>460	CDD:289560	10/63 (16%)
		HrpA	<484..973	CDD:224557	87/482 (18%)
		HA2	694..763	CDD:214852	18/80 (23%)
		OB_NTP_bind	823..945	CDD:285018	15/90 (17%)
dhx37	XP_005172500.1	HrpA	200..1007	CDD:224557	167/889 (19%)
		DEXDc	272..412	CDD:238005	36/147 (24%)
		HELICc	583..667	CDD:197757	19/126 (15%)
		HA2	730..781	CDD:282288	7/50 (14%)
		HA2	761..>813	CDD:214852	16/56 (29%)
		OB_NTP_bind	<918..1004	CDD:285018	10/52 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900