DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vir and VIRMA

DIOPT Version :9

Sequence 1:	NP_524900.1	Gene:	vir / 47869	FlyBaseID:	FBgn0003977	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_056311.2	Gene:	VIRMA / 25962	HGNCID:	24500	Length:	1812	Species:	Homo sapiens

Alignment Length:	2062	Identity:	507/2062 - (24%)
Similarity:	840/2062 - (40%)	Gaps:	495/2062 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VDDGSELLFFDTFSHEEV-TDINLDLVQFPKPVFITQVRIIPLGARVQADFPGGVRLGATNPSKF 67
            ||...||||.|||.|... ...::|:|:||..|:|.:||:||.|.|..:..|.....|.|:|..|
Human     3 VDSAMELLFLDTFKHPSAEQSSHIDVVRFPCVVYINEVRVIPPGVRAHSSLPDNRAYGETSPHTF 67

  Fly    68 DLEFFVNDLGMPAASAFENLGLLRYNQNDCIHLDCSQEKIVTDGLVLRGWYSTITLAIYGIFTNS 132
            .|:.|.|::..|:|..|:.||.|.|::|..| :.....|:.||||||||||:.:||||||.....
Human    68 QLDLFFNNVSKPSAPVFDRLGSLEYDENTSI-IFRPNSKVNTDGLVLRGWYNCLTLAIYGSVDRV 131

  Fly   133 VTEPIASPTLPCEPVGPEIANLSGEVLLQEDVLKDEWQEPMQAELLTAHKGNVSDYDPEDMEYGM 197
            ::....||..|..|..|                    .:|..:                     :
Human   132 ISHDRDSPPPPPPPPPP--------------------PQPQPS---------------------L 155

  Fly   198 SRDHYHQHAEEQEQ------REMRRLRRSTHSTDHSPPPPRRSHTHSESNDREYIRCSRDKGSRD 256
            .|:..|...|:::|      |...|..|    |...||||     ..:.:|...:..|.||
Human   156 KRNPKHADGEKEDQFNGSPPRPQPRGPR----TPPGPPPP-----DDDEDDPVPLPVSGDK---- 207

  Fly   257 WSRSPEYSSHRSRRKRSERSRSVVDEHKWPRTPPASIDSPTRPRSPDTMDYEDEDSRSHYKMQSS 321
                .|.:.||             :::..|       .||.|...|....|.||......:.:..
Human   208 ----EEDAPHR-------------EDYFEP-------ISPDRNSVPQEGQYSDEGEVEEEQQEEG 248

  Fly   322 HYRHSSESLHRGERDRDDEDR---SCTPQEQFEPILSDDEIIGDDEE----DD-----AVDAAAI 374
            ........:.. |.|.|::||   ...|:|:.|    |:|..|:::|    ||     :.|...|
Human   249 EEDEDDVDVEE-EEDEDEDDRRTVDSIPEEEEE----DEEEEGEEDEEGEGDDGYEQISSDEDGI 308

  Fly   375 AEYERE--------LEAAA---AAAPPAIDAFEPWQK---PLLVFEGDMAAHFCKELETLKLLFK 425
            |:.|||        :|..|   |:.||.  .::|:.:   |||.|.       |....|.::...
Human   309 ADLERETFKYPNFDVEYTAEDLASVPPM--TYDPYDRELVPLLYFS-------CPYKTTFEIEIS 364

  Fly   426 KLVLQ--------------TRCENVNAFSEEHGA----SVDEREQFVYLGEQLNNQLGYLAQHYK 472
            ::..|              ...|.::.:.|:.||    :::|....:..|      |.||
Human   365 RMKDQGPDKENSGAIEASVKLTELLDLYREDRGAKWVTALEEIPSLIIKG------LSYL----- 418

  Fly   473 RRNFVLQQFFGNDELHLRQAANVLQIALSFQAACMQPQPAFKIRHIKLGARMAELLGS-SEELFQ 536
                   |.....:..|.|..:....||:.|.|..|| .|..:|.:|.|.::...|.. ..:...
Human   419 -------QLKNTKQDSLGQLVDWTMQALNLQVALRQP-IALNVRQLKAGTKLVSSLAECGAQGVT 475

  Fly   537 HLLKEHKFDIFEAVFRLYHEPYMALSIKLQLLKAVYALLDTRMGIEHFMGAKNN---GYQMIVEA 598
            .||:.   .:...:|.|....:::.|:||...||:.:::....|:|.|:..:.|   |||.::|.
Human   476 GLLQA---GVISGLFELLFADHVSSSLKLNAFKALDSVISMTEGMEAFLRGRQNEKSGYQKLLEL 537

  Fly   599 IKTAKLTRTKYALQAIIKKLHLWEGLESVQIWCRRLFVDRIIIPGNRDQMEDTVITCQQIEFAFE 663
            |...:..|...|..||::|.|.:|.|..::.....|......:|.:.:...||....::....:|
Human   538 ILLDQTVRVVTAGSAILQKCHFYEVLSEIKRLGDHLAEKTSSLPNHSEPDHDTDAGLERTNPEYE 602

  Fly   664 ------MLMDALFSSQLSYLQPRRFL--------------------PVSKKFEV---VTDPTAQR 699
                  |.||.|.||.:|..:..|.:                    || |.|..   :|.|..:.
Human   603 NEVEASMDMDLLESSNISEGEIERLINLLEEVFHLMETAPHTMIQQPV-KSFPTMARITGPPERD 666

  Fly   700 SFGNALQSYLGQNSLAESLLVMLANCKELPATT-----YLSMLDLMHTLLRSHVGIDYFVDDAFP 759
            .....|..||..:...|.:.::|:    :|.|:     ..:..|::..|.:|..|:.:|:.: :.
Human   667 DPYPVLFRYLHSHHFLELVTLLLS----IPVTSAHPGVLQATKDVLKFLAQSQKGLLFFMSE-YE 726

  Fly   760 VTQTIVAILLGLDEVPRNPEEKEEKAEKSDAEDKAMEVENEAVEAGGEKPTPPTADEEGKPVAAP 824
            .|..::..|....:     :::||..:.....|.|
Human   727 ATNLLIRALCHFYD-----QDEEEGLQSDGVIDDA------------------------------ 756

  Fly   825 ISVPAPAAAPQVRPRPILRPVLPRLARLGIEMSYKVQTRYHLDAIA-------YAAAAPEYDAVK 882
                                       ..:.:....||   |..|.       ...|:.|.|...
Human   757 ---------------------------FALWLQDSTQT---LQCITELFSHFQRCTASEETDHSD 791

  Fly   883 LATHMHAIYSQTCDPAGRQHTVEVLGLNNNLKIFMDLIKKEQRLQTQRQLSSPGTKYKSPVLSYA 947
            |...:|.:|..|.:|.||.....|..|..||:..:.|::    ..::..|....:| ||...:||
Human   792 LLGTLHNLYLITFNPVGRSAVGHVFSLEKNLQSLITLME----YYSKEALGDSKSK-KSVAYNYA 851

  Fly   948 VDMVDACVRYCEQLDYLIEHGGVILELAKNHETFEPSVSAVLQEMYVYMKPLEAINVFVYDDIMP 1012
            ..::...|:....:..|.:|...:|:|.|..|.     :|.|||:..:::||:.:. |..:.|..
Human   852 CILILVVVQSSSDVQMLEQHAASLLKLCKADEN-----NAKLQELGKWLEPLKNLR-FEINCIPN 910

  Fly  1013 LVEVIGRSLDYLTTFPG-DLIMAMRILRYLSI-SKPLAGQKAPPVTEELKHRFVALQLYAADGVQ 1075
            |:|.:.:::|.|.|..| .|..|:|:|..::. ..|:.||:     ::||.....:||::|:|:.
Human   911 LIEYVKQNIDNLMTPEGVGLTTALRVLCNVACPPPPVEGQQ-----KDLKWNLAVIQLFSAEGMD 970

  Fly  1076 LCIQIMERLCAYFEQP-------GAHAPALMTIQGVHCCQIMLPTLQILRELLSYAILCRDGT-- 1131
            ..|:::::|.:...||       |.....:.||....|...:|.|:  |.|||      |.|:
Human   971 TFIRVLQKLNSILTQPWRLHVNMGTTLHRVTTISMARCTLTLLKTM--LTELL------RGGSFE 1027

  Fly  1132 YKDLTAIDHLVKVYYLLYYFPTRCQAGPEVEQCKMEVVQTLLAYTQ-PNEQ---DEESLHKSLWT 1192
            :||:.....||.::.||...|...:...:.::.:.:::..||.:|| .||:   .||:|..:.|:
Human  1028 FKDMRVPSALVTLHMLLCSIPLSGRLDSDEQKIQNDIIDILLTFTQGVNEKLTISEETLANNTWS 1092

  Fly  1193 LMIREVLKNV-DGPAHFIPGLKLLAELLPLPLPMPQPLCDQLQQQHKQRL-ITERKLWSAHLHPQ 1255
            ||::|||.:: ..|..|..||.||:|||||||||.   ..|:.:.|...: :..|||||.|||.|
Human  1093 LMLKEVLSSILKVPEGFFSGLILLSELLPLPLPMQ---TTQVIEPHDISVALNTRKLWSMHLHVQ 1154

  Fly  1256 SGQIAKLVEALAPSSFPQLSELLQRVCMQLSDLAPNMTLLIAKTITELLCNEYQTSNCIP----T 1316
            :..:.::|.:.:.::...:..:|:|:|:||.|||....|||.:|:.:|:..:.|:::...    |
Human  1155 AKLLQEIVRSFSGTTCQPIQHMLRRICVQLCDLASPTALLIMRTVLDLIVEDLQSTSEDKEKQYT 1219

  Fly  1317 TNLERLLRFSTRLCAFAPLKSSMLSILSG------KFWELFQSLLAL--NEFNDVV-SNCQEAVH 1372
            :...|||.....|.:....|.::|.:::|      ::.|:||.||||  :..:.|: ..|.|.|.
Human  1220 SQTTRLLALLDALASHKACKLAILHLINGTIKGDERYAEIFQDLLALVRSPGDSVIRQQCVEYVT 1284

  Fly  1373 RILDSFLDSGISLI---SHKSTASPALNLAAALPPKELIPRIIDAVFSNLTSVEVTHGISILAVR 1434
            .||.|..|..|:||   |.:.:.|....|:.:||.|||:..|.|.:.:.|.:.|.::...:..||
Human  1285 SILQSLCDQDIALILPSSSEGSISELEQLSNSLPNKELMTSICDCLLATLANSESSYNCLLTCVR 1349

  Fly  1435 NLVILTEHDFTFYHLAQLLKQKITEFQAWMERVI--LHNETVEYNAN-IESLILLLRS------- 1489
            .::.|.|||:..:||...|::..:...:.::||:  ...:|.|..:: :|.:..:|.|
Human  1350 TMMFLAEHDYGLFHLKSSLRKNSSALHSLLKRVVSTFSKDTGELASSFLEFMRQILNSDTIGCCG 1414

  Fly  1490 ----LTQIEPPPAMSAMPHRTLKLGATELAQLVEFQD-------IELAKPPVLSRILTVMEKHKA 1543
                |.::|     .|...||:.:.|.||.||::.::       :||.|        .|:|..|.
Human  1415 DDNGLMEVE-----GAHTSRTMSINAAELKQLLQSKEESPENLFLELEK--------LVLEHSKD 1466

  Fly  1544 VANEAALSD----LKQLILLQASKQEILAGTSTETPPEAEGEANPSASSCSASLTVEPYLPQAEG 1604
            ..|..:|.|    |||::                   |:.|:..|.:..     .|||.|...|.
Human  1467 DDNLDSLLDSVVGLKQML-------------------ESSGDPLPLSDQ-----DVEPVLSAPES 1507

  Fly  1605 IVTQYEARPIFTRFCATAENAQLTARYWLDPLPIELIE-DMNEPIYERIACDLTDLANVCLNPDL 1668
            :...:..|..:.  .|...:.||.: .|..|...|.|: |:     :.:..||.:|:..|.: |.
Human  1508 LQNLFNNRTAYV--LADVMDDQLKS-MWFTPFQAEEIDTDL-----DLVKVDLIELSEKCCS-DF 1563

  Fly  1669 NVAGDSKRVMNLSGSPQSNREMTPTAPCFRTRRVEVEPATGRPEKKMFVSSVRGRGFARP----- 1728
            ::..:.:|...   |..|:...|.|...|:         .|:.:.:.|::|.....:..|
Human  1564 DLHSELERSFL---SEPSSPGRTKTTKGFK---------LGKHKHETFITSSGKSEYIEPAKRAH 1616

  Fly  1729 --PPSRG-------------DLFRSRPPNTSRPPSLHVDDFLALETCGAQPTGPTGYNKIPSMLR 1778
              ||.||             |:||.|..|||||||:|||||:|.|:....|     .:.||...|
Human  1617 VVPPPRGRGRGGFGQGIRPHDIFRQRKQNTSRPPSMHVDDFVAAESKEVVP-----QDGIPPPKR 1676

  Fly  1779 GSRVGR----------NRGSRISAAAAFRQKKMMRIGSP---------------SSWA--ESP-G 1815
            ..:|.:          |||.|    .||..:.  |..:|               |||:  .:| |
Human  1677 PLKVSQKISSRGGFSGNRGGR----GAFHSQN--RFFTPPASKGNYSRREGTRGSSWSAQNTPRG 1735

  Fly  1816 SYRSA--SDSHFSSSD----SHYSSPHYSGRPRGRGLRSR----PSY 1852
            :|..:  ..|:|:...    ...||..|...||.|..|.|    ||:
Human  1736 NYNESRGGQSNFNRGPLPPLRPLSSTGYRPSPRDRASRGRGGLGPSW 1782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vir	NP_524900.1	VIR_N	6..263	CDD:292534	76/263 (29%)
VIRMA	NP_056311.2	VIR_N	5..235	CDD:292534	84/308 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..302		47/252 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	576..596		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1616..1635		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1663..1812		31/131 (24%)
		MPLKIP	1703..>1808	CDD:292140	20/82 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141211
Domainoid	1	1.000	326	1.000	Domainoid score	I1181
eggNOG	1	0.900	-	-		E1_KOG4822
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	419	1.000	Inparanoid score	I1814
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48370
OrthoDB	1	1.010	-	-		D114891at33208
OrthoFinder	1	1.000	-	-		FOG0006529
OrthoInspector	1	1.000	-	-		oto88822
orthoMCL	1	0.900	-	-		OOG6_107758
Panther	1	1.100	-	-	LDO	PTHR23185
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5505
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770