DRSC/TRiP Functional Genomics Resources

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Protein Alignment NFIL3 and vri

DIOPT Version :10

Sequence 1:NP_005375.2 Gene:NFIL3 / 4783 HGNCID:7787 Length:462 Species:Homo sapiens
Sequence 2:NP_477191.1 Gene:vri / 33759 FlyBaseID:FBgn0016076 Length:729 Species:Drosophila melanogaster


Alignment Length:628 Identity:132/628 - (21%)
Similarity:215/628 - (34%) Gaps:218/628 - (34%)


- Green bases have known domain annotations that are detailed below.


Human     1 MQLRKMQTVKKEQASLDASSNVDKMMVLNSALTEVSEDSTT-------------GEELLLSEGSV 52
            ::|..:........|.:.:||:..:.:...:::..|.||..             |:.::....|.
  Fly   143 VRLSNISPTLSMNGSSNEASNLHPLSMYGGSISPQSNDSGMSDSLGKYVPGSGYGDGMMAQSPSQ 207

Human    53 GKNKSSAC-----------RRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDLVLENKLI 106
            |.|...:.           |::|||.||.|||..||::||:|||||||||||||.||:|||.::|
  Fly   208 GGNGPQSALTAAQKELFSQRKQREFTPDNKKDESYWDRRRRNNEAAKRSREKRRYNDMVLEQRVI 272

Human   107 ALGEENATLKAELLSLKLKFGLISSTAYAQE--IQKLSNSTAVYFQDYQTSKSNVSSFVDEHEPS 169
            .|.:||..|||:|.:::.||.:......:.|  :..|..|..|.....:...|..........||
  Fly   273 ELTKENHVLKAQLDAIRDKFNISGENLVSVEKILASLPTSEQVLSNTKRAKMSGSGGSSSGSSPS 337

Human   170 MVSSS---------------CISVIKHSPQSSLSDVSEVSSVEHTQESSV--------------- 204
            ...|.               .:|.:.:.|..:....:.|.||.|...:.|               
  Fly   338 GSGSGEGSPQGGHNGYPVGPPLSPLIYGPNGNARPEATVKSVHHIHHAGVAPPPTHLQQLVVPQS 402

Human   205 --------QGSCRSPENKFQIIKQEPMELESYTREPRDDRGS----------------------- 238
                    |.....|..:.||  .:|.:.:...:||....||                       
  Fly   403 QTQHLYQPQPQQHQPHQQQQI--SQPPQQQQQQQEPSPSAGSSSPVISDPHNRPPSTTIANLQVQ 465

Human   239 --------------------------YTA--------------------SIYQNYMGNSFSGYSH 257
                                      |.|                    |.|:::: .:.:.:||
  Fly   466 LQQALNRNVRPEDLDSLRKVVAAGALYNAAAVVGAPPPPPSAGLYVPAPSAYKDHL-EAAAAWSH 529

Human   258 ----------------------------------SPPLLQVNRSSSNSPRTSETDDGVVGKSSDG 288
                                              ||....:..|:::|..:|.:..|.|    .|
  Fly   530 NVEAAVSSSAVDAVSSSSVSGSAASVLNLSRRACSPSYEHMLSSTTSSTLSSASSSGAV----SG 590

Human   289 EDEQQVPKGPIH-SPVELKHVHATVVKVPEVNSSA---LPHKLRIKAKAMQIKVEAFDNEFEATQ 349
            :|||:  ..|.| :|::|:.      ..|:..|.|   ||.|||.|:       ...|.:..||.
  Fly   591 DDEQE--HEPAHMAPLQLQR------SSPQQGSDANNCLPLKLRHKS-------HLGDKDAAATA 640

Human   350 KLSSPIDMTSKRHFELEKHSAPSMVHSSLTPFSVQVTNIQD-----WSLKSEHWHQKELSGKTQN 409
            .|       |.:|.:.|    |:...:|...::....|..|     .|:.|..| ..:|..|   
  Fly   641 LL-------SLQHIKQE----PNCSRASPPAWNDGGDNSSDERDSGISIASAEW-TAQLQRK--- 690

Human   410 SFKTGVVEMKDSGYKVSDPENLYLKQGIANLSAEVVSLKRLIA 452
                 ::..|::....|...:..||..:..|.:||.|:|.::|
  Fly   691 -----LLAPKEANVVTSAERDQMLKSQLERLESEVASIKMILA 728

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NFIL3NP_005375.2 bZIP_NFIL3 72..131 CDD:269842 34/58 (59%)
coiled coil 73..131 CDD:269842 33/57 (58%)
Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 79..95 13/15 (87%)
Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 99..106 3/6 (50%)
Vert_IL3-reg_TF 130..461 CDD:368956 80/475 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 189..237 12/70 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 258..302 13/44 (30%)
Necessary for transcriptional repression and sufficient for interaction with DR1. /evidence=ECO:0000269|PubMed:8836190 299..363 17/67 (25%)
vriNP_477191.1 bZIP_NFIL3 238..297 CDD:269842 34/58 (59%)
coiled coil 239..297 CDD:269842 33/57 (58%)

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