Protein Alignment ATP1A3 and ENA1

DIOPT Version :10

• Sequence 1: NP_001243143.1
• Gene: ATP1A3 / 478
• HGNCID: 801
• Length: 1026
• Species: Homo sapiens
• Sequence 2: NP_010325.1
• Gene: ENA1 / 851610
• SGDID: S000002447
• Length: 1091
• Species: Saccharomyces cerevisiae
• Alignment Length: 1124
• Identity: 300/1124 - (26%)
• Similarity: 477/1124 - (42%)
• Gaps: 248/1124 - (22%)

Human    47 HKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGA 111
            |.::.||......|...:|||..:....|...|.|.|..............|:.....::|.|..
Yeast    18 HTLTAEEAAEFIGTSLTEGLTQDEFVHRLKTVGENTLGDDTKIDYKAMVLHQVCNAMIMVLLISM 82

Human   112 ILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIR 176
            |:.|..:             :...|.|::.|:.:.......||.|::|.|.|.||:....|.|||
Yeast    83 IISFAMH-------------DWITGGVISFVIAVNVLIGLVQEYKATKTMNSLKNLSSPNAHVIR 134

Human   177 EGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLE 241
            .|:...:|:::||.||:..:|.||.:|||||:|.......|.|.|||||.|.::..:.......|
Yeast   135 NGKSETINSKDVVPGDICLVKVGDTIPADLRLIETKNFDTDESLLTGESLPVSKDANLVFGKEEE 199

Human   242 TR-----NITFFSTNCVEGTARGVVVATGDRTVMGRIA---------------------TLAS-- 278
            |.     |:.|.|:..|:|.|:|:|:.|...:.:|:||                     |..|
Yeast   200 TSVGDRLNLAFSSSAVVKGRAKGIVIKTALNSEIGKIAKSLQGDSGLISRDPSKSWLQNTWISTK 264

Human   279 -------GLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLE----AVIFLIGIIV 332
                   |..|| ||:..::.....|:..:||...:      :::.....:    ..|:.|.:.:
Yeast   265 KVTGAFLGTNVG-TPLHRKLSKLAVLLFWIAVLFAI------IVMASQKFDVDKRVAIYAICVAL 322

Human   333 ANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMW-- 395
            :.:|..|:..:|:.:::.|..|..:|.:|:.|:::|.||:.:.|||||||||||.:|....:|
Yeast   323 SMIPSSLVVVLTITMSVGAAVMVSRNVIVRKLDSLEALGAVNDICSDKTGTLTQGKMLARQIWIP 387

Human   396 ---------------------------------------------FDNQIHEADTTEDQSGTSFD 415
                                                         |.::::|.|..||.....|.
Yeast   388 RFGTITISNSDDPFNPNEGNVSLIPRFSPYEYSHNEDGDVGILQNFKDRLYEKDLPEDIDMDLFQ 452

Human   416 KSSHTWVALSHIAGLCNRAVFK----------GGQDNIPV----LKRDVAGDA--SESALLKCIE 464
            |    |:..:.:|.:.  .|||          |....|.:    .|.|:..:|  .|.:..:..|
Yeast   453 K----WLETATLANIA--TVFKDDATDCWKAHGDPTEIAIQVFATKMDLPHNALTGEKSTNQSNE 511

Human   465 LSSGSVKLMRERNKK--------VAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRC 521
            ....|   :.:.|:|        :||.||:||.|...|::...  ::..|.:..|||.|.|:..|
Yeast   512 NDQSS---LSQHNEKPGSAQFEHIAEFPFDSTVKRMSSVYYNN--HNETYNIYGKGAFESIISCC 571

Human   522 STILLQGKE----QPL-DEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDVNF 581
            |:  ..||:    .|| |.:::...:|.| .|...|.|||||.     .:.|.|....|....|.
Yeast   572 SS--WYGKDGVKITPLTDCDVETIRKNVY-SLSNEGLRVLGFA-----SKSFTKDQVNDDQLKNI 628

Human   582 TTD------NLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISE- 639
            |::      :|.|:||:.:.||||.....||.|...|||.|.|:|||...||||||:.|||:..
Yeast   629 TSNRATAESDLVFLGLIGIYDPPRNETAGAVKKFHQAGINVHMLTGDFVGTAKAIAQEVGILPTN 693

Human   640 ----GNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQ 700
                ..|.|:.:                   |:.|:.....:.|::|::  ....:|.||.|||.
Yeast   694 LYHYSQEIVDSM-------------------VMTGSQFDGLSEEEVDDL--PVLPLVIARCSPQT 737

Human   701 KLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGV 765
            |:.::|...|:.....:|||||||||:||.|::|:||||.||||||:|:|::|.|||||||:..|
Yeast   738 KVRMIEALHRRKKFCTMTGDGVNDSPSLKMANVGIAMGINGSDVSKEASDIVLSDDNFASILNAV 802

Human   766 EEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIM-----ANIPLPLGTITILCIDLGTDMVPAISL 825
            ||||.:.||::|.:...|..|:.:....::.::     .....||..:.:|.|.:.|...||:.|
Yeast   803 EEGRRMTDNIQKFVLQLLAENVAQALYLIIGLVFRDENGKSVFPLSPVEVLWIIVVTSCFPAMGL 867

Human   826 AYEAAESDIMKRQPRNPRTDKLVNERLI-SMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGI 889
            ..|.|..|:|.|.|.:........|.:| :.|||.|.....:..|             .|:|.||
Yeast   868 GLEKAAPDLMDRPPHDSEVGIFTWEVIIDTFAYGIIMTGSCMASF-------------TGSLYGI 919

Human   890 RLNWDDRTVNDLEDSYGQQW--TYEQRKVVEFTCHTAFFVSIVVVQWADLI----ICKTRRN--- 945
            .   ..|..:|.:.:|....  .|..|        :|.|.::.   |..||    :...||:
Yeast   920 N---SGRLGHDCDGTYNSSCRDVYRSR--------SAAFATMT---WCALILAWEVVDMRRSFFR 970

Human   946 ----------SVFQQGMKNKIL----IFGLFEETALAAF-LSYCPGMDVALRMYPLKPSWWFCAF 995
                      ..|:....|:.|    |||.     ::|| :.|.|.::..:.::....:.|..|.
Yeast   971 MHPDTDSPVKEFFRSIWGNQFLFWSIIFGF-----VSAFPVVYIPVINDKVFLHKPIGAEWGLAI 1030

Human   996 PYSFLIFVYDEIRKLILRR 1014
            .::...::..|:.|...||
Yeast  1031 AFTIAFWIGAELYKCGKRR 1049

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP1A3	NP_001243143.1	ATPase-IIC_X-K	30..1026	CDD:273445	300/1124 (27%)
ENA1	NP_010325.1	ATPase-IID_K-Na	11..1055	CDD:130586	300/1124 (27%)