Protein Alignment ATP1A3 and SERCA

DIOPT Version :10

• Sequence 1: NP_001243143.1
• Gene: ATP1A3 / 478
• HGNCID: 801
• Length: 1026
• Species: Homo sapiens
• Sequence 2: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Alignment Length: 1072
• Identity: 316/1072 - (29%)
• Similarity: 510/1072 - (47%)
• Gaps: 182/1072 - (16%)

Human    47 HKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGA 111
            |..:||:....:.||..:|||..:.:....:.|||.|........|.....|.......:|.:.|
  Fly     5 HSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAA 69

Human   112 ILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIR 176
            |:.|:   :....|.:.:.......:|:..::|.......:||..:...:|:.|...|:...|:|
  Fly    70 IISFV---LALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVR 131

Human   177 EGEK--MQVNAEEVVVGDLVEIKGGDRVPADLRI--ISAHGCKVDNSSLTGESEPQTRSPDCTHD 237
            :.:.  .:|.|:|:|.|||||:..||::|||:||  |.:...::|.|.|||||....:..|...|
  Fly   132 QDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIPD 196

Human   238 NPL---ETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLIT 299
            ...   :.:||.|..||...|.|||||:.||..|.:|:|.|..|..|..|||:..:::.|.:.::
  Fly   197 PRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLS 261

Human   300 GVAVFLGVSFFILSL------ILGYTWLEAVIF----LIGIIVANVPEGLLATVTVCLTLTAKRM 354
            .|...:.|:.:.:::      ..|.:|::..|:    .:.:.||.:||||.|.:|.||.|..:||
  Fly   262 KVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRM 326

Human   355 ARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTT---EDQSGTSFDK 416
            |:||.:|::|.:|||||.||.||||||||||.|:|:|:.|:..:::...|::   .:.:|::::.
  Fly   327 AKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYEP 391

Human   417 SSHTWV--------------ALSHIAGLCNRAV-----FKGGQDNIPVLKRDVAGDASESALLKC 462
            ....::              .||.|..:||.:.     ||...:.:        |:|:|:||:..
  Fly   392 IGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKV--------GEATETALIVL 448

Human   463 IE-LSSGSVKL--MRERNKKVA---EIPFNSTNKYQLSIHETEDPNDNRYL-------------- 507
            .| |:|.||..  :..|:..:|   ||......::.|     |...|.:.:
  Fly   449 AEKLNSFSVNKSGLDRRSAAIACRGEIETKWKKEFTL-----EFSRDRKSMSSYCTPLKASRLGT 508

Human   508 ---LVMKGAPERILDRCSTILLQGKEQPLDEEMKE---AFQNAYLELGGLGERVLGFCHYYL--- 563
               |.:|||||.:|:||:...:...:.||...:|.   |....|    |.|...|......:
  Fly   509 GPKLFVKGAPEGVLERCTHARVGTTKVPLTSALKAKILALTGQY----GTGRDTLRCLALAVADS 569

Human   564 ---PEEQFPKGFAFDCDDVNFTTD------NLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMV 619
               |:|.          |:..:|.      ||.|||::.|:||||..|.|::.:||:|||:||::
  Fly   570 PMKPDEM----------DLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVI 624

Human   620 TGDHPITAKAIAKGVGIISEGNETV-EDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDE 683
            |||:..||:||.:.:|:.:|..:|. :..:.|   ....::|.:.||.|....
  Fly   625 TGDNKATAEAICRRIGVFAEDEDTTGKSYSGR---EFDDLSPTEQKAAVARSR------------ 674

Human   684 ILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQA 748
                    :|:|..||.|..|||..|....|.|:|||||||:||||||:||:||| :|:.|:|.|
  Fly   675 --------LFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSA 730

Human   749 ADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCI 813
            |:|:|.||||:|||:.|||||.|::|:|:.|.|.::|||.|:....|.....:|..|..:.:|.:
  Fly   731 AEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWV 795

Human   814 DLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAE 878
            :|.||.:||.:|.:...:.|||::.||.      .:|.|||      |.:     ||.|..|
  Fly   796 NLVTDGLPATALGFNPPDLDIMEKPPRK------ADEGLIS------GWL-----FFRYMAI--- 840

Human   879 NGFLPG-NLVGIRLNWDDRTVNDLEDSYGQQWTY-------EQRKVVE---FTCHTAFFVSIVVV 932
             ||..| ..||....|...:....:.||.|...:       ::.|.|:   |:...|..:::.|:
  Fly   841 -GFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVL 904

Human   933 QWADLIICKTRRNSVFQQGMKNKILI-------FGLFEETALAAFLS----YCPGMDVALRMYPL 986
            ...:::   ...||:    .:|:.||       ..|....||:..|.    |...:....::.||
  Fly   905 VTIEML---NAMNSL----SENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPL 962

Human   987 KPSWWFCAFPYSFLIFVYDEIRKLILRRNPGG 1018
            ....|.....:|..:.:.||..|.:.|:...|
  Fly   963 SAEEWITVMKFSIPVVLLDETLKFVARKIADG 994

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP1A3	NP_001243143.1	ATPase-IIC_X-K	30..1026	CDD:273445	316/1072 (29%)
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	314/1065 (29%)