Protein Alignment ATP1A3 and SPoCk

DIOPT Version :10

• Sequence 1: NP_001243143.1
• Gene: ATP1A3 / 478
• HGNCID: 801
• Length: 1026
• Species: Homo sapiens
• Sequence 2: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Alignment Length: 1086
• Identity: 307/1086 - (28%)
• Similarity: 487/1086 - (44%)
• Gaps: 183/1086 - (16%)

Human    10 RIATSQD-KKDDKDSPKKNKGKERRDLDDLKKEVAMTEHKM---SVEEVCRKYNTDCVQGLTHSK 70
            ::|..:| |:.|:|:..:..|...:....|..|:.::..:.   |..||..:...|...||..::
  Fly    71 KVADMKDCKEPDEDNVDQQNGNIIQTGLTLTPEMLLSTSESSTHSASEVAGRLQVDVRTGLKWTE 135

Human    71 AQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNLYL 135
            |:......|.|.|......|.|.|:..| |....|||.:|:.|..:   |....:|..|
  Fly   136 AKYRAKIIGHNELLLVAEDPTWKKYIEQ-FRNPLILLLLGSALVSV---IMKQFDDAVS------ 190

Human   136 GIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGD 200
             |.:|.::::|  .::.||.:|.|.:|..|.:||.:...:|||......|.|:|.||:|.:..||
  Fly   191 -ITIAILIVVT--VAFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGD 252

Human   201 RVPADLRIISAHGCKVDNSSLTGESEPQTRSPDC--------THDNPLETRNITFFSTNCVEGTA 257
            |||||:|:..|....:|.||.|||:||..:..|.        .|.|   .:||.|..|....|..
  Fly   253 RVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNVKDHSN---MKNIAFMGTLVRCGNG 314

Human   258 RGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWL- 321
            :|:||:||:|:..|.:..:....|..|||:...::     |.|..:.. .||.|:.:|:...||
  Fly   315 KGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMD-----ILGAQLSF-YSFLIIGVIMLLGWLQ 373

Human   322 -----EAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKT 381
                 |.....:.:.||.:||||...|||.|.|...|||::|.:||.|..|||||..:.||||||
  Fly   374 GKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKT 438

Human   382 GTLTQNRMTVAHMWFDNQIHEADTT----EDQSGTSFDKSSHTWVALSHIAGL------CNRAVF 436
            ||||:|.|| |.:...:..:.||.|    .||........::..:|.::|..|      ||.|..
  Fly   439 GTLTKNEMT-ATIIITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAKTNITNLLEIGAVCNNAYI 502

Human   437 KGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQL--SIHETE 499
            :.|         .:.|..:|.||: .:.:.:| :....|...::.|.||:|..|...  .||:..
  Fly   503 QNG---------TLLGQPTEGALV-AVAMKNG-MYATAENYVRIQEYPFSSEQKMMAVKCIHKYN 556

Human   500 DPNDNRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLP 564
              |:...:...|||.|.:|.:|:......:..||.::.:..|.....|:|..|.|||...
  Fly   557 --NNKEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALA----- 614

Human   565 EEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGD------- 622
                 ||.:.         .:|.:.||:.:.||||..|.:::.....:|::|.|||||
  Fly   615 -----KGRSM---------QDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALA 665

Human   623 ------------HPITAKAIAKGVGIISEG--------NETVEDI----AARLNIPVSQVNPRDA 663
                        |.|.|...|.||.:.|..        ...:::|    .|:..:|:...|....
  Fly   666 IDPSRRLQAVPTHAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGI 730

Human   664 KACVIH-----GTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVN 723
            .  .||     |.::......|:|::..|.:  ||.|.||:.||.||:..||.|.||.:||||||
  Fly   731 D--TIHHQTLSGQEMDQMNEHQLDKVANNVS--VFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVN 791

Human   724 DSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIP 788
            |..||||||||:|||..|:||.|:||||||::|:|.:|:..:|||:.||.|::..:.:.|:::|.
  Fly   792 DGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIA 856

Human   789 EITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLI 853
            .:....|..:.:|..||..:.||.|::..|..||.||..|..:.|::|::|||.:...:....::
  Fly   857 ALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVV 921

Human   854 SMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVE 918
            :                   |:|:.:..:.|.|                      |.: ||::.:
  Fly   922 N-------------------VLLSASIIVLGTL----------------------WVF-QREMAD 944

Human   919 FTC------HTAFFVSIVVVQWADLIICKTRRNSVFQQGM-KNKILIFGLFEETALAAFLSYCPG 976
            .|.      .|..|...|.....:.:.|:::..|||..|: .|::.:..:.........:.|.|.
  Fly   945 GTLGKTKRDTTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPP 1009

Human   977 MDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEK 1022
            :.:..:...|.|...|.....:..:.|..||:|         |.|:
  Fly  1010 LQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKK---------WFER 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP1A3	NP_001243143.1	ATPase-IIC_X-K	30..1026	CDD:273445	301/1065 (28%)
SPoCk	NP_001262220.1	P-type_ATPase_SPCA	139..1042	CDD:319779	289/1003 (29%)