Protein Alignment ATP1A3 and cta3

DIOPT Version :10

• Sequence 1: NP_001243143.1
• Gene: ATP1A3 / 478
• HGNCID: 801
• Length: 1026
• Species: Homo sapiens
• Sequence 2: NP_595246.1
• Gene: cta3 / 2541204
• PomBaseID: SPBC839.06
• Length: 1037
• Species: Schizosaccharomyces pombe
• Alignment Length: 1084
• Identity: 315/1084 - (29%)
• Similarity: 487/1084 - (44%)
• Gaps: 215/1084 - (19%)

Human    51 VEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCF 115
            :::|..::.|....||||.:||..|:..|.|.|........|....||:.....::|.:.|.|.|
pombe    15 IKDVESEFLTSIPNGLTHEEAQNRLSEYGENRLEADSGVSAWKVLLRQVLNAMCVVLILAAALSF 79

Human   116 LAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEK 180
                   ||.|...|.      |::|::::.....:.||.|:.|.|:|.:.:....|.|.|..:.
pombe    80 -------GTTDWIEGG------VISAIIVLNITVGFIQEYKAEKTMDSLRTLASPMAHVTRSSKT 131

Human   181 MQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCT----HDNPLE 241
            ..:::..:|.||:|.:|.||.||||||::.....:.|.:.|||||.|..:....|    .|.|:.
pombe   132 DAIDSHLLVPGDVVVLKTGDVVPADLRLVETVNFETDEALLTGESLPVIKDAHATFQMNEDVPIG 196

Human   242 TR-NITFFSTNCVEGTARGVVVATGDRTVMGRIAT------------------------------ 275
            .| |:.:.|:...:|.|:|:..|||.:|.:|.||.
pombe   197 DRINLAYSSSIVTKGRAKGICYATGMQTQIGAIAAGLRQKGKLFQRPEKDEPNYRRKLNKYYLKV 261

Human   276 ------LASGLEVGKTPIAIEIEHFIQLITGVAVFLGV------SFFILSLILGYTWLEAVIFLI 328
                  ...||.|| ||:..::.....::..:|:.|.:      ||.:.:        |..|:.|
pombe   262 TSYYVQRVLGLNVG-TPLQRKLTVLAYILFCIAIILAIIVMAAHSFHVTN--------EVSIYAI 317

Human   329 GIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAH 393
            .:.::.:||.|:|.:::.:.:..|.|:::..:|:.|||:|.||..:.||||||||:||.:|....
pombe   318 SLGISIIPESLIAVLSITMAMGQKNMSKRRVIVRKLEALEALGGVTDICSDKTGTITQGKMITRR 382

Human   394 MWFDN----QIHEADTTEDQSGT--------------------SFDKS---SHTWVALSHIAGLC 431
            :|..:    .:..:|......||                    :.|.|   |..::.|.....||
pombe   383 VWIPSYGYLSVDTSDANNPTIGTVSGLEAAMQDVLKEKKQEMKNIDPSNQPSDQFIPLLKTCALC 447

Human   432 NRAVFKGGQDNIPVLKRDVAGDASESAL-LKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSI 495
            |.:.....:....|:|    |:.:|.|| :.....:.|...|:: .|..|.|.||:|..|....|
pombe   448 NLSTVNQTETGEWVVK----GEPTEIALHVFSKRFNYGKEDLLK-TNTFVREYPFDSEIKRMAVI 507

Human   496 HETEDPNDNRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCH 560
            :|.:   ..:|.:..|||.||||:||||......|:| |.|:..|....   |...|.|||....
pombe   508 YEDQ---QGQYTVYAKGAVERILERCSTSNGSTLEEP-DRELIIAQMET---LAAEGLRVLALAT 565

Human   561 YYLPE----EQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTG 621
            ..:.:    |..|:..|         ..:|.||.|:.:.||||.....||..|..|||:|.|:||
pombe   566 KVIDKADNWETLPRDVA---------ESSLEFVSLVGIYDPPRTESKGAVELCHRAGIRVHMLTG 621

Human   622 DHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKA--CVIHGTDLKDFTSEQIDEI 684
            |||.||||||:.||||.               |.  ::.||...  .|:.|:.....:.|::|.:
pombe   622 DHPETAKAIAREVGIIP---------------PF--ISDRDPNMSWMVMTGSQFDALSDEEVDSL 669

Human   685 LQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAA 749
              ....:|.||.:||.|:.::|...|:.|.||:|||||||||:||:|::|:|||..||||:|.|:
pombe   670 --KALCLVIARCAPQTKVKMIEALHRRKAFVAMTGDGVNDSPSLKQANVGIAMGQNGSDVAKDAS 732

Human   750 DMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMA-----NIPL---PLG 806
            |::|.||||:|||..:||||.:|||:.:.:.:.|.||:.|:   :|.::.     .:.|   |:.
pombe   733 DIVLTDDNFSSIVNAIEEGRRMFDNIMRFVLHLLVSNVGEV---ILLVVGLAFRDEVHLSVFPMS 794

Human   807 TITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLIS-MAYG-QIGMIQALGGF 869
            .:.||..::.|...|::.|..|.|:.|:|:|.|.:.:........::. |.|| .:|::..:
pombe   795 PVEILWCNMITSSFPSMGLGMELAQPDVMERLPHDNKVGIFQKSLIVDMMVYGFFLGVVSLM--- 856

Human   870 FSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQW 934
             ::.||:  .||..|||                 ||.....|.......|...:|.|   .||.:
pombe   857 -TWVVIM--YGFGTGNL-----------------SYDCNAHYHAGCNDVFKARSAVF---AVVTF 898

Human   935 ADLIIC---KTRRNSVFQ-QG---------------MKNKILIFGLFEETALAAF----LSYCP- 975
            ..||:.   |...||:|. .|               ::||.|.:.:    ||||.    ..|.|
pombe   899 CILIMAVEVKNFDNSLFNLHGIPWGEWNFRYFLHTLVENKFLAWAI----ALAAVSVFPTIYIPV 959

Human   976 -GMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILR--RNP 1016
             ..||....| :...|...|....|..| |.||.|.|.|  .||
pombe   960 INRDVFKHTY-IGWEWGVVAVAVMFYFF-YVEIWKSIRRSLTNP 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP1A3	NP_001243143.1	ATPase-IIC_X-K	30..1026	CDD:273445	315/1084 (29%)
cta3	NP_595246.1	ATPase-IID_K-Na	5..1003	CDD:130586	315/1084 (29%)