Protein Alignment ATP1A3 and eat-6

DIOPT Version :10

• Sequence 1: NP_001243143.1
• Gene: ATP1A3 / 478
• HGNCID: 801
• Length: 1026
• Species: Homo sapiens
• Sequence 2: NP_506269.1
• Gene: eat-6 / 179796
• WormBaseID: WBGene00001137
• Length: 996
• Species: Caenorhabditis elegans
• Alignment Length: 1008
• Identity: 734/1008 - (72%)
• Similarity: 846/1008 - (83%)
• Gaps: 20/1008 - (1%)

Human    25 KKNKGKERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTT 89
            ||:|   :::|.|||:||.|.||.:.:||:..:..|:...|||..||||:||::|||||:||.||
 Worm     3 KKDK---KQELHDLKQEVKMDEHIVPIEELVARLGTNLETGLTRQKAQEVLAKNGPNALSPPETT 64

Human    90 PEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQE 154
            |||:|||:.|||||::|||:|||||::||.:...|.:.||.|||||||||..||:|||.|.||||
 Worm    65 PEWIKFCKNLFGGFAMLLWVGAILCYIAYSVDYFTMEYPSKDNLYLGIVLMTVVVITGVFQYYQE 129

Human   155 AKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNS 219
            :||||||:|||||||..|||.|:|:|.||..||:||||:||:|||||||||||::||.|.|||||
 Worm   130 SKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVDNS 194

Human   220 SLTGESEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGK 284
            |||||||||:||||||::||||||||.|||||.|||||:|:|:.|||.|||||||.|||||:.|.
 Worm   195 SLTGESEPQSRSPDCTNENPLETRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGM 259

Human   285 TPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTL 349
            ||||.||||||.||||||||||:||||::.||||.||.||:||||||||||||||:|||||||||
 Worm   260 TPIAREIEHFIHLITGVAVFLGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTL 324

Human   350 TAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQ----- 409
            ||||||.|||||||||||||||||||||||||||||||||||||||:|..|||.||||.|
 Worm   325 TAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWYDETIHECDTTETQTSQEK 389

Human   410 -SGTSFDKSSHTWVALSHIAGLCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLM 473
             :|.||:       ||..||.|||||.||.||.:.|:|:||..|||||.||||..||:.|:|..:
 Worm   390 RTGASFE-------ALVRIASLCNRAEFKAGQQDTPILRRDCTGDASEIALLKFTELTQGNVIAV 447

Human   474 RERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMK 538
            ||:|||:||||||||||||:|||:    |.:.||||||||||||||.||||.|.|||..|.::::
 Worm   448 REKNKKIAEIPFNSTNKYQVSIHD----NGDHYLLVMKGAPERILDVCSTIFLNGKESELTDKLR 508

Human   539 EAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVP 603
            |.|..|||||||:||||||||.:.||.::|||||.||.::|||...||.||||||||||||||||
 Worm   509 EDFNTAYLELGGMGERVLGFCDFVLPADKFPKGFKFDVEEVNFPLKNLRFVGLMSMIDPPRAAVP 573

Human   604 DAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVI 668
            |||.|||||||||:|||||||||||||||.|||||:|.|||||||.|..|||.:||||:|||.||
 Worm   574 DAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIISDGTETVEDIAIRRGIPVEEVNPREAKAAVI 638

Human   669 HGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADI 733
            ||:||::.:.:|:.||::.|:|||||||||||||:||||.|:||.||||||||||||||||||||
 Worm   639 HGSDLREMSEDQLAEIIKYHSEIVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADI 703

Human   734 GVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIM 798
            |||||||||||||||||||||||||||||.|||||||||||||||||||||||||||:|||.:|:
 Worm   704 GVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLTYIL 768

Human   799 ANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMI 863
            ..|||||||:||||||||||||||||||||.|||||||||||:|..||||||||||:||||||||
 Worm   769 FGIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQPRDPIRDKLVNERLISLAYGQIGMI 833

Human   864 QALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHTAFFVS 928
            ||..|||:||.|:|:|||:|.:|..:|..||.|..|::.|||||:|||..||::|:||.||:|||
 Worm   834 QASAGFFTYFWIMADNGFMPWDLYQLRAQWDSRAYNNVLDSYGQEWTYANRKILEYTCQTAYFVS 898

Human   929 IVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFC 993
            |||||||||||.||||||:.||||.|..|.|||..|||||.|:.||||:|..||||.|:.|||||
 Worm   899 IVVVQWADLIISKTRRNSLVQQGMSNWTLNFGLVFETALAWFMCYCPGLDNGLRMYGLRFSWWFC 963

Human   994 AFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY 1026
            |.|:|.|||||||||:.::||.||||||:||||
 Worm   964 ALPFSILIFVYDEIRRFLIRRYPGGWVERETYY 996

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP1A3	NP_001243143.1	ATPase-IIC_X-K	30..1026	CDD:273445	729/1001 (73%)
eat-6	NP_506269.1	P-type_ATPase_Na-K_like	40..993	CDD:319794	715/963 (74%)
		HAD	<574..657	CDD:432733	60/82 (73%)