DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dip-C and FRA1

DIOPT Version :9

Sequence 1:	NP_001287306.1	Gene:	Dip-C / 47769	FlyBaseID:	FBgn0000455	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_013071.1	Gene:	FRA1 / 850630	SGDID:	S000003952	Length:	749	Species:	Saccharomyces cerevisiae

Alignment Length:	495	Identity:	97/495 - (19%)
Similarity:	174/495 - (35%)	Gaps:	166/495 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SLYNTDVDYVFRQESYFQYLFGVKEPGCYGILTIDVKTGAQKSVLFVPR-FPDEYGTWMGELLGL 117
            :|..:|:||   ...:|.|                |.....:::||... |.|:...:. ::.|:
Yeast   339 NLRGSDIDY---NPVFFSY----------------VAINEDETILFTNNPFNDDISEYF-KINGI 383

  Fly   118 Q--EFKAMYE-----VDEVFYVDEMSVYLEGASPKLILTL-SGTNSDSGLTLQPPDFAGKEKYVT 174
            :  .::.::|     ..:....:...:..:.||.:::..| :.||::..:        .|:....
Yeast   384 EVRPYEQIWEHLTKITSQASSAEHEFLIPDSASWQMVRCLNTSTNANGAI--------AKKMTAQ 440

  Fly   175 DCNLLYPILSECRVIKSPEEIE------------VLRYVA-----KVSSDAHIKVMRF------M 216
            :..:::..:...:.||:..||:            :::|.|     .|..:|.|...|.      :
Yeast   441 NFAIIHSPIDVLKSIKNDIEIKNAHKAQVKDAVCLVQYFAWLEQQLVGREALIDEYRAAEKLTEI 505

  Fly   217 RPGRMEFEGESLFLHHAYSVGGCRHASYTCICGSGTNSSILHYGHAGAPNSKPVQDGDLCLFDMG 281
            |..:..|.|.                |:..|..:|:|::|:||. ....||..:....:.|.|.|
Yeast   506 RKTQRNFMGN----------------SFETISSTGSNAAIIHYS-PPVENSSMIDPTKIYLCDSG 553

  Fly   282 ANYCGYAADITCTFPANGKFTDDQKFIYNAVLDARNAVTESARDGVSWVDMHKLAGRVLLQRL-- 344
            :.:.....|||.|.... |.|.::...|..|                      |.|.:.|:||
Yeast   554 SQFLEGTTDITRTIHLT-KPTKEEMDNYTLV----------------------LKGGLALERLIF 595

  Fly   345 ---KEGGMLKGDVEEMLEAGVSGVFQPHGLGHLIG--LDVHD--VG-GYLPKEPKRPSEPWLSKL 401
               ..|..:.....:.|.:  .|:...||.||.||  |:||:  :| |:.|.....|
Yeast   596 PENTPGFNIDAIARQFLWS--RGLDYKHGTGHGIGSFLNVHEGPMGVGFRPHLMNFP-------- 650

  Fly   402 RFARILKAGMYVTIEPGCYFINWLMDRALADPNIAKFINAEMFNRFRNFGGVRIEDDVLITKT-- 464
                 |:||..::.|||.|                  .:.|.        |:|||.|:||.|.
Yeast   651 -----LRAGNIISNEPGYY------------------KDGEY--------GIRIESDMLIKKATE 684

  Fly   465 -----GVENFAIVP--------RTVEDIEATMTCKYDSPV 491
                 ..||..:||        :.:.:.|.|...:|.:.|
Yeast   685 KGNFLKFENMTVVPYCRKLINTKLLNEEEKTQINEYHARV 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dip-C	NP_001287306.1	AMP_N	12..158	CDD:198079	18/112 (16%)
		PRK10879	57..483	CDD:182804	93/482 (19%)
		Prolidase	195..468	CDD:238520	67/312 (21%)
FRA1	NP_013071.1	Creatinase_N	109..270	CDD:420017
		Creatinase_N_2	282..460	CDD:406573	21/148 (14%)
		APP	463..688	CDD:238518	66/305 (22%)
		Peptidase_M24_C	687..749	CDD:406572	8/38 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0006
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810