DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dip-C and XPNPEP2

DIOPT Version :9

Sequence 1:	NP_001287306.1	Gene:	Dip-C / 47769	FlyBaseID:	FBgn0000455	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_003390.4	Gene:	XPNPEP2 / 7512	HGNCID:	12823	Length:	674	Species:	Homo sapiens

Alignment Length:	476	Identity:	106/476 - (22%)
Similarity:	175/476 - (36%)	Gaps:	147/476 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VLLEGGKDQS-LYN---TDVDYVFRQESYFQYLFGVKEPGCYGILT-IDVKTGAQKSVLFVPRFP 104
            |||...::.: |:|   :|:.|     :.|.|        .|.:|| ..::..|.||     ||.
Human   237 VLLSALEETAWLFNLRASDIPY-----NPFFY--------SYTLLTDSSIRLFANKS-----RFS 283

  Fly   105 DEYGTWMGE------LLGLQEFKAMYEVDEVFYVDEMSVYLEGASPKLILTLSGTNSDSGLTLQP 163
            .|..:::..      .:.::::..:.:..:.:.:.::.::: |.|    .|:.|..
Human   284 SETLSYLNSSCTGPMCVQIEDYSQVRDSIQAYSLGDVRIWI-GTS----YTMYGIY--------- 334

  Fly   164 PDFAGKEKYVTDCNLLYPILSECRVIKSPEEIEVLRYVAKVSSDAHIKVMRFM-------RPGRM 221
             :...|||.|||   .|..:...:.:|:.:|..:|:  |....|| :.|:|::       ..|.:
Human   335 -EMIPKEKLVTD---TYSPVMMTKAVKNSKEQALLK--ASHVRDA-VAVIRYLVWLEKNVPKGTV 392

  Fly   222 E----------FEGESLFLHHAYSVGGCRHASYTCICGSGTNSSILHYGHAGAPNSKPVQDGDLC 276
            :          |.||..|     |.|    .|:..|..||.|:::.||......|.|...| ::.
Human   393 DEFSGAEIVDKFRGEEQF-----SSG----PSFETISASGLNAALAHYSPTKELNRKLSSD-EMY 447

  Fly   277 LFDMGANYCGYAADITCTFPANGKFTDDQKFIYNAVLDARNAVTESARDGVSWVDMHKLAGRVLL 341
            |.|.|..|.....|||.|... |..:..||..|..||             :..:|:    .|::.
Human   448 LLDSGGQYWDGTTDITRTVHW-GTPSAFQKEAYTRVL-------------IGNIDL----SRLIF 494

  Fly   342 QRLKEGGMLKGDVEEML-EAGVSGVFQPHGLGHLIG--LDVHDVGGYLPKEPKRPSEPWLSKLRF 403
            .....|.|::......| :||::   ..||.||.||  |.||:               |....:.
Human   495 PAATSGRMVEAFARRALWDAGLN---YGHGTGHGIGNFLCVHE---------------WPVGFQS 541

  Fly   404 ARILKA-GMYVTIEPGCYFINWLMDRALADPNIAKFINAEMFNRFRNFGGVRIEDDVLITKTGVE 467
            ..|..| ||:.:||||.|             ...:|             |:|:||..|:    ||
Human   542 NNIAMAKGMFTSIEPGYY-------------KDGEF-------------GIRLEDVALV----VE 576

  Fly   468 NFAIVPRTVEDIEATMTCKYD 488
            .....|.:....|......||
Human   577 AKTKYPGSYLTFEVVSFVPYD 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dip-C	NP_001287306.1	AMP_N	12..158	CDD:198079	22/123 (18%)
		PRK10879	57..483	CDD:182804	100/456 (22%)
		Prolidase	195..468	CDD:238520	70/293 (24%)
XPNPEP2	NP_003390.4	Creatinase_N	54..184	CDD:279639
		Creatinase_N_2	202..361	CDD:292807	30/159 (19%)
		PepP	<348..601	CDD:223085	77/329 (23%)
		APP	365..583	CDD:238518	71/296 (24%)
		Peptidase_M24_C	585..648	CDD:292806	3/13 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0006
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810