Protein Alignment Dip-C and XPNPEP1

DIOPT Version :9

• Sequence 1: NP_001287306.1
• Gene: Dip-C / 47769
• FlyBaseID: FBgn0000455
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: NP_001311062.1
• Gene: XPNPEP1 / 7511
• HGNCID: 12822
• Length: 695
• Species: Homo sapiens
• Alignment Length: 600
• Identity: 132/600 - (22%)
• Similarity: 200/600 - (33%)
• Gaps: 228/600 - (38%)

  Fly    24 AGKAILKE-----------LLPGLKFNDGN------------------LLVLLEG---GKDQSLY 56
            ||.||:.|           .|...|..|.|                  :.||.||   |.|..:.
Human   103 AGTAIITEEHAAMWTDGRYFLQAAKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVDPLII 167

  Fly    57 NTD----VDYVFRQESYFQYLFGVKE-------------PGCYGILTIDVK-TG----------- 92
            .||    :..|.|...:  :|..|||             | |..:||:.:. ||
Human   168 PTDYWKKMAKVLRSAGH--HLIPVKENLVDKIWTDRPERP-CKPLLTLGLDYTGISWKDKVADLR 229

  Fly    93 ---AQKSVL-FVPRFPDEYGTWMGELLGLQEFKAMYEVDEVFY------VDEMSVYLEG------ 141
               |:::|: ||....||. .|:..|.|     :..|.:.||:      ::.:.::::|
Human   230 LKMAERNVMWFVVTALDEI-AWLFNLRG-----SDVEHNPVFFSYAIIGLETIMLFIDGDRIDAP 288

  Fly   142 -ASPKLILTLSGTNSDSGLTLQP------------PDFAGKEK-YVTD---------------CN 177
             ....|:|.| |..::..:.:.|            .|.:.:|| :|:|               |.
Human   289 SVKEHLLLDL-GLEAEYRIQVHPYKSILSELKALCADLSPREKVWVSDKASYAVSETIPKDHRCC 352

  Fly   178 LLYPILSECRVIKSPEEIEVLRYVAKVSSDAHIKVMRFMRPGRMEFEGESL-----FLHHAYSVG 237
            :.|..:...:.:|:..|.|.:|       .||||            :..:|     :|......|
Human   353 MPYTPICIAKAVKNSAESEGMR-------RAHIK------------DAVALCELFNWLEKEVPKG 398

  Fly   238 GCRH-------------------ASYTCICGSGTNSSILHYGHAGAPNSKPVQDGDLCLFDMGAN 283
            |...                   .|:..|..:|.|.:|:||......| :.:...::.|.|.||.
Human   399 GVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETN-RTLSLDEVYLIDSGAQ 462

  Fly   284 YCGYAADITCTFPANGKFTDDQKFIYNAVLDARNAVTESARDGVSWVDMHKLAGRVLLQRLKEGG 348
            |.....|:|.|... |..|..:|..:..||....||:.:                 :.....:|.
Human   463 YKDGTTDVTRTMHF-GTPTAYEKECFTYVLKGHIAVSAA-----------------VFPTGTKGH 509

  Fly   349 MLKGDVEEMLEAGVSGVFQPHGLGHLIG--LDVHDVGGYLPKEPKRPS-EPWLSKLRFARILKAG 410
            :|.......|  ..||:...||.||.:|  |:||:  |......|..| ||          |:||
Human   510 LLDSFARSAL--WDSGLDYLHGTGHGVGSFLNVHE--GPCGISYKTFSDEP----------LEAG 560

  Fly   411 MYVTIEPGCYFINWLMDRALADPNIAKFINAEMFNRFRNFGGVRIEDDVLI----TKTGVEN--- 468
            |.||.|||.|     .|.|.                     |:|||:.||:    ||....|
Human   561 MIVTDEPGYY-----EDGAF---------------------GIRIENVVLVVPVKTKYNFNNRGS 599

  Fly   469 FAIVPRTVEDIEATM 483
            ....|.|:..|:..|
Human   600 LTFEPLTLVPIQTKM 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dip-C	NP_001287306.1	AMP_N	12..158	CDD:198079	46/211 (22%)
		PRK10879	57..483	CDD:182804	116/533 (22%)
		Prolidase	195..468	CDD:238520	71/303 (23%)
XPNPEP1	NP_001311062.1	Creatinase_N	53..197	CDD:304957	23/95 (24%)
		Creatinase_N_2	207..369	CDD:292807	30/168 (18%)
		PepP	239..609	CDD:223085	99/454 (22%)
		APP	372..594	CDD:238518	70/299 (23%)
		Peptidase_M24_C	600..>627	CDD:292806	3/14 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0006
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810