DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dip-C and XPNPEP3

DIOPT Version :9

Sequence 1:	NP_001287306.1	Gene:	Dip-C / 47769	FlyBaseID:	FBgn0000455	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_071381.1	Gene:	XPNPEP3 / 63929	HGNCID:	28052	Length:	507	Species:	Homo sapiens

Alignment Length:	494	Identity:	142/494 - (28%)
Similarity:	220/494 - (44%)	Gaps:	99/494 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ELLPGLK-----FNDGNLLVLL------EGGKDQSL---------YNTDVDYVFRQESYFQYLFG 75
            |:.|||.     .....|:.|:      :.|.||::         .:.|:.|.|.|::.|.||.|
Human    62 EVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCG 126

  Fly    76 VKEPGCYGILTIDVKTGAQ----KSVLFVPRFPDEYGTWMGELLGLQEFKAMYEVDEVFYVDEMS 136
            .:||.  .||.:....|.|    |::|||||.......|.|...|.....|:..|||.:.::|..
Human   127 FQEPD--SILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQ 189

  Fly   137 VYLEGASPKLILTLSGTN---------------SDSGLTLQPPDFAGKEKYVTDCNLLYPILSEC 186
            ..|    ||:   .:.||               ||   .:||...| |.|.......:..::...
Human   190 HLL----PKM---KAETNMVWYDWMRPSHAQLHSD---YMQPLTEA-KAKSKNKVRGVQQLIQRL 243

  Fly   187 RVIKSPEEIEVLRYVAKVSSDAHIKVMRFMRPGRMEFEGESLFLHHAYS----VGGCRHASYTCI 247
            |:||||.|||.::...|::|.|.|:.| |.....:    |..||:..:.    ..|....:|..:
Human   244 RLIKSPAEIERMQIAGKLTSQAFIETM-FTSKAPV----EEAFLYAKFEFECRARGADILAYPPV 303

  Fly   248 CGSGTNSSILHYGHAGAPNSKPVQDGDLCLFDMGANYCGYAADITCTFPANGKFTDDQKFIYNAV 312
            ...|..|:.|||    ..|::.::||::.|.|.|.....|.:|||.|:|.||:||..|..:|.||
Human   304 VAGGNRSNTLHY----VKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAV 364

  Fly   313 LDARNAVTESARDGVSWVDMHKLAGRVLLQRLKEGGMLKGDVEEMLEAGVSGVFQPHGLGHLIGL 377
            |:.:.........|.|..:::.:...::.|:||:.|::| :::|......:..:.||.:||.:|:
Human   365 LEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMK-NIKENNAFKAARKYCPHHVGHYLGM 428

  Fly   378 DVHDVGGYLPKEPKRPSEPWLSKLRFARILKAGMYVTIEPGCYFINWLMDRALADPNIAKFINAE 442
            ||||.    |..|:  |.|          |:.||.:|||||.|.           |...|    :
Human   429 DVHDT----PDMPR--SLP----------LQPGMVITIEPGIYI-----------PEDDK----D 462

  Fly   443 MFNRFRNFGGVRIEDDVLITK-TGVENFAIVPRTVEDIE 480
            ...:||.. ||||||||::|: :.:...|..|:.:.|||
Human   463 APEKFRGL-GVRIEDDVVVTQDSPLILSADCPKEMNDIE 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dip-C	NP_001287306.1	AMP_N	12..158	CDD:198079	44/165 (27%)
		PRK10879	57..483	CDD:182804	133/448 (30%)
		Prolidase	195..468	CDD:238520	82/277 (30%)
XPNPEP3	NP_071381.1	Interaction with TNFRSF1B. /evidence=ECO:0000269\|PubMed:25609706	54..79		4/16 (25%)
		PRK10879	67..506	CDD:182804	139/489 (28%)
		AMP_N	72..205	CDD:282980	38/141 (27%)
		Prolidase	252..490	CDD:238520	82/279 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0006
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D200485at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R584
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850