DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dip-C and PEPD

DIOPT Version :9

Sequence 1:	NP_001287306.1	Gene:	Dip-C / 47769	FlyBaseID:	FBgn0000455	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_000276.2	Gene:	PEPD / 5184	HGNCID:	8840	Length:	493	Species:	Homo sapiens

Alignment Length:	472	Identity:	247/472 - (52%)
Similarity:	326/472 - (69%)	Gaps:	10/472 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VPMTLFRNNRDRAGKAILKELLPGLKFNDGNLLVLLEGGKDQSLYNTDVDYVFRQESYFQYLFGV 76
            ||:.||..||.|..:.:.|.  |.::   ...:|:|:||::...|.||...:|||||:|.:.|||
Human    18 VPLALFALNRQRLCERLRKN--PAVQ---AGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGV 77

  Fly    77 KEPGCYGILTIDVKTGAQKSVLFVPRFPDEYGTWMGELLGLQEFKAMYEVDEVFYVDEMSVYLEG 141
            .||||||:  |||.||  ||.|||||.|..:.||||::...:.||..|.||:|.||||::..|..
Human    78 TEPGCYGV--IDVDTG--KSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTS 138

  Fly   142 ASPKLILTLSGTNSDSGLTLQPPDFAGKEKYVTDCNLLYPILSECRVIKSPEEIEVLRYVAKVSS 206
            ..|.::|||.|.|:|||...:...|.|..|:..:..:|:|.:.||||.|:..|:|||||..|:||
Human   139 QKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISS 203

  Fly   207 DAHIKVMRFMRPGRMEFEGESLFLHHAYSVGGCRHASYTCICGSGTNSSILHYGHAGAPNSKPVQ 271
            :||.:||:.::.|..|:|.||||.|:.||.||.||:|||||||||.||::||||||||||.:.:|
Human   204 EAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQ 268

  Fly   272 DGDLCLFDMGANYCGYAADITCTFPANGKFTDDQKFIYNAVLDARNAVTESARDGVSWVDMHKLA 336
            :||:||||||..|..:|:||||:||||||||.|||.:|.|||.:..||..:.:.||.|.|||:||
Human   269 NGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLA 333

  Fly   337 GRVLLQRLKEGGMLKGDVEEMLEAGVSGVFQPHGLGHLIGLDVHDVGGYLPKEPKRPSEPWLSKL 401
            .|:.|:.|...|:|.|.|:.|::|.:..||.||||||.:|:|||||||| |:..:|..||.|..|
Human   334 DRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGY-PEGVERIDEPGLRSL 397

  Fly   402 RFARILKAGMYVTIEPGCYFINWLMDRALADPNIAKFINAEMFNRFRNFGGVRIEDDVLITKTGV 466
            |.||.|:.||.:|:|||.|||:.|:|.|||||..|.|:|.|:..|||.|||||||:||::|.:|:
Human   398 RTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGI 462

  Fly   467 ENFAIVPRTVEDIEATM 483
            |....||||||:|||.|
Human   463 ELLTCVPRTVEEIEACM 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dip-C	NP_001287306.1	AMP_N	12..158	CDD:198079	66/145 (46%)
		PRK10879	57..483	CDD:182804	232/425 (55%)
		Prolidase	195..468	CDD:238520	157/272 (58%)
PEPD	NP_000276.2	AMP_N	18..155	CDD:198079	66/145 (46%)
PEPD	NP_000276.2	Prolidase	192..467	CDD:238520	158/275 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151836
Domainoid	1	1.000	324	1.000	Domainoid score	I1207
eggNOG	1	0.900	-	-		E1_COG0006
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H239
Inparanoid	1	1.050	492	1.000	Inparanoid score	I1422
Isobase	1	0.950	-	0	Normalized mean entropy	S1276
OMA	1	1.010	-	-		QHG53590
OrthoDB	1	1.010	-	-		D200485at33208
OrthoFinder	1	1.000	-	-		FOG0005445
OrthoInspector	1	1.000	-	-		oto88307
orthoMCL	1	0.900	-	-		OOG6_102295
Panther	1	1.100	-	-	LDO	PTHR43226
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R584
SonicParanoid	1	1.000	-	-		X3871
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750