DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dip-C and xpnpep2

DIOPT Version :9

Sequence 1:	NP_001287306.1	Gene:	Dip-C / 47769	FlyBaseID:	FBgn0000455	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_957326.2	Gene:	xpnpep2 / 394007	ZFINID:	ZDB-GENE-040426-1151	Length:	703	Species:	Danio rerio

Alignment Length:	387	Identity:	89/387 - (22%)
Similarity:	132/387 - (34%)	Gaps:	124/387 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 LLGLQEFKAMYEVDEVFYVDEMSVYLEGASPKL----ILTLSGTNSDSGLTLQPPD---FAGKEK 171
            ||.:.:.......:.:  .:|:.|||..:..:.    :|..|...:.....||.|:   :.|.|
Zfish   292 LLSMDDIWLFVHTERI--TEELKVYLNASCYQSLCVHLLEYSSVRTYLQSYLQRPNVRVWVGTE- 353

  Fly   172 YVTDCNLLY---------------PILSECRVIKSPEEIEVLRYVAKVSSDAHIK----VMRFMR 217
            |....  ||               |:|: .:.:|...|..:|:       :||::    ||:.:.
Zfish   354 YTNQA--LYELITPEDKLLTSTYSPVLT-TKAVKDMTEQRILK-------EAHVRDAVAVMQLLL 408

  Fly   218 ------PGRMEFEGESLFLHHAYSVGGCRH-------ASYTCICGSGTNSSILHYGHAGAPNSKP 269
                  |     ||....:..|.....||.       .|:..|..||.|:::.||..:.....|.
Zfish   409 WLEKKVP-----EGAETEITAALYADQCRSKQKNSRGPSFETISASGPNAALAHYSPSNDTARKL 468

  Fly   270 VQDGDLCLFDMGANYCGYAADITCTFPANGKFTDDQKFIYNAVLDARNAVTESA-RDGVSWVDMH 333
            ..| ::.|.|.|..|.....|||.|... ||.||.||..|..||.....::.:. ..|...|.|.
Zfish   469 TVD-EMYLVDSGGQYLDGTTDITRTVHW-GKPTDFQKEAYTRVLMGNIEISRTIFPAGTRGVYME 531

  Fly   334 KLAGRVLLQRLKEGGMLKGDVEEMLEAGVSGVFQPHGLGHLIG--LDVHDVGGYLPKEPKRPSEP 396
            .|..|.|.    |.|:..|                ||.||.:|  ..||:
Zfish   532 MLGRRALW----EVGLNYG----------------HGTGHGVGNYFGVHE--------------- 561

  Fly   397 WLSKLRFARI-LKAGMYVTIEPGCYFINWLMDRALADPNIAKFINAEMFNRFRNFGGVRIED 457
            |....:...| .:.||:.:||||.|..|                         :| |:||||
Zfish   562 WPVGFQSNNIPFQEGMFTSIEPGYYKEN-------------------------DF-GIRIED 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dip-C	NP_001287306.1	AMP_N	12..158	CDD:198079	8/47 (17%)
		PRK10879	57..483	CDD:182804	89/387 (23%)
		Prolidase	195..468	CDD:238520	69/284 (24%)
xpnpep2	NP_957326.2	Creatinase_N	79..209	CDD:279639
		Creatinase_N_2	232..388	CDD:292807	19/101 (19%)
		PepP	261..628	CDD:223085	89/387 (23%)
		APP	392..611	CDD:238518	69/281 (25%)
		Peptidase_M24_C	611..675	CDD:292806
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0006
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810