DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dip-C and Pepd

DIOPT Version :9

Sequence 1:	NP_001287306.1	Gene:	Dip-C / 47769	FlyBaseID:	FBgn0000455	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001009641.1	Gene:	Pepd / 292808	RGDID:	1594571	Length:	492	Species:	Rattus norvegicus

Alignment Length:	485	Identity:	249/485 - (51%)
Similarity:	325/485 - (67%)	Gaps:	17/485 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AFQMGS-GYAVPMTLFRNNRDRAGKAILKELLPGLKFN---DGNLLVLLEGGKDQSLYNTDVDYV 63
            :|.:|: ...||:.||..||.|        |...|:.|   .....|:|:||::...|.||...:
  Rat     8 SFSLGNETLKVPLALFALNRQR--------LCERLRKNGAVQAGSAVVLQGGEEMQRYCTDTSII 64

  Fly    64 FRQESYFQYLFGVKEPGCYGILTIDVKTGAQKSVLFVPRFPDEYGTWMGELLGLQEFKAMYEVDE 128
            |||||:|.:.|||.|.||||:  |||.||  ||.|||||.|..|.||||::...:.||..|.||:
  Rat    65 FRQESFFHWAFGVIESGCYGV--IDVDTG--KSTLFVPRLPASYATWMGKIHSKEHFKEKYAVDD 125

  Fly   129 VFYVDEMSVYLEGASPKLILTLSGTNSDSGLTLQPPDFAGKEKYVTDCNLLYPILSECRVIKSPE 193
            |.|.||::..|...:|.::|||.|.|:|||...:...|.|..|:..:..:|:|.:.||||.|:..
  Rat   126 VQYADEIASVLTSRNPSVLLTLRGVNTDSGNVCREASFEGISKFTVNNTILHPEIVECRVFKTDM 190

  Fly   194 EIEVLRYVAKVSSDAHIKVMRFMRPGRMEFEGESLFLHHAYSVGGCRHASYTCICGSGTNSSILH 258
            |:|||||..::||:||.:||:.::.|..|:|.||||.|:.||.||.||.||||||.||.|:::||
  Rat   191 ELEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHYCYSKGGMRHTSYTCICCSGENAAVLH 255

  Fly   259 YGHAGAPNSKPVQDGDLCLFDMGANYCGYAADITCTFPANGKFTDDQKFIYNAVLDARNAVTESA 323
            ||||||||.:.::|||:||||||..|..:|:||||:||||||||||||.||.|||.:...|..:.
  Rat   256 YGHAGAPNDRTIKDGDICLFDMGGEYYCFASDITCSFPANGKFTDDQKAIYEAVLRSCRTVMSTM 320

  Fly   324 RDGVSWVDMHKLAGRVLLQRLKEGGMLKGDVEEMLEAGVSGVFQPHGLGHLIGLDVHDVGGYLPK 388
            :.||.|.|||:||.|:.|:.|...|:|.|.|:.||:..:..||.||||||.:|||||||||| |:
  Rat   321 KPGVWWPDMHRLADRIHLEELTRIGLLSGSVDAMLQVHLGAVFMPHGLGHFLGLDVHDVGGY-PE 384

  Fly   389 EPKRPSEPWLSKLRFARILKAGMYVTIEPGCYFINWLMDRALADPNIAKFINAEMFNRFRNFGGV 453
            ..:|..||.|..||.||.|:.||.:|:|||.|||:.|:|:|||||..|.|.|.|:..||||||||
  Rat   385 GVERIDEPGLRSLRTARHLEPGMVLTVEPGIYFIDHLLDQALADPAQACFFNQEVLQRFRNFGGV 449

  Fly   454 RIEDDVLITKTGVENFAIVPRTVEDIEATM 483
            |||:||::|.:|:|....||||||:|||.|
  Rat   450 RIEEDVVVTDSGMELLTCVPRTVEEIEACM 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dip-C	NP_001287306.1	AMP_N	12..158	CDD:198079	66/148 (45%)
		PRK10879	57..483	CDD:182804	231/425 (54%)
		Prolidase	195..468	CDD:238520	157/272 (58%)
Pepd	NP_001009641.1	AMP_N	18..155	CDD:198079	66/148 (45%)
		PepP	52..476	CDD:223085	229/428 (54%)
		Prolidase	192..467	CDD:238520	158/275 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	322	1.000	Domainoid score	I1183
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H239
Inparanoid	1	1.050	486	1.000	Inparanoid score	I1387
OMA	1	1.010	-	-		QHG53590
OrthoDB	1	1.010	-	-		D200485at33208
OrthoFinder	1	1.000	-	-		FOG0005445
OrthoInspector	1	1.000	-	-		oto95455
orthoMCL	1	0.900	-	-		OOG6_102295
Panther	1	1.100	-	-	LDO	PTHR43226
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3871
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980