DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crc and Atf5

DIOPT Version :9

Sequence 1:	NP_001260672.1	Gene:	crc / 47767	FlyBaseID:	FBgn0000370	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_758839.3	Gene:	Atf5 / 282840	RGDID:	628902	Length:	281	Species:	Rattus norvegicus

Alignment Length:	100	Identity:	36/100 - (36%)
Similarity:	52/100 - (52%)	Gaps:	13/100 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 ISSSSSPAPTTIEQSASQPKKRTRTYGRGVEDRKIRKKEQNKNAATRYRQKKKLEMENVLGEEHV 346
            :.|.|.|||.....|.           ||  |||.:|::|||:||.||||:|:.|.|.:.||...
  Rat   190 LPSPSRPAPYPSPAST-----------RG--DRKQKKRDQNKSAALRYRQRKRAEGEALEGECQG 241

  Fly   347 LSKENEQLRRTLQERHNEMRYLRQLIREFYHERKR 381
            |...|.:||...:....|::|::.|:.|.|..|.:
  Rat   242 LEARNRELRERAESVEREIQYVKDLLIEVYKARSQ 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crc	NP_001260672.1	bZIP_ATF4	313..374	CDD:269840	25/60 (42%)
crc	NP_001260672.1	coiled coil	315..374	CDD:269840	23/58 (40%)
Atf5	NP_758839.3	Required for protein stabilization induced by IL1B. /evidence=ECO:0000250\|UniProtKB:Q9Y2D1	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..152
		Interaction with PTP4A1. /evidence=ECO:0000250\|UniProtKB:O70191	119..216		12/38 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..236		24/58 (41%)
		bZIP_ATF4	208..270	CDD:269840	25/61 (41%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	209..229		12/19 (63%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	235..249		4/13 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I10325
eggNOG	1	0.900	-	-		E1_KOG4571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002572
OrthoInspector	1	1.000	-	-		otm44439
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13044
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.000