DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crc and ATF5

DIOPT Version :9

Sequence 1:	NP_001260672.1	Gene:	crc / 47767	FlyBaseID:	FBgn0000370	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_001180575.1	Gene:	ATF5 / 22809	HGNCID:	790	Length:	282	Species:	Homo sapiens

Alignment Length:	115	Identity:	39/115 - (33%)
Similarity:	60/115 - (52%)	Gaps:	3/115 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 CSSIADADEDWVPELISSSSSPAPTTIEQSASQPKKRTRTYGRGVEDRKIRKKEQNKNAATRYRQ 331
            |.:.|..:|..:|.|......|.|:..:.|...|.....| .||  |||.:|::|||:||.||||
Human   166 CRNEAGQEEVGMPPLPPPQQPPPPSPPQPSRLAPYPHPAT-TRG--DRKQKKRDQNKSAALRYRQ 227

  Fly   332 KKKLEMENVLGEEHVLSKENEQLRRTLQERHNEMRYLRQLIREFYHERKR 381
            :|:.|.|.:.||...|...|.:|:...:....|::|::.|:.|.|..|.:
Human   228 RKRAEGEALEGECQGLEARNRELKERAESVEREIQYVKDLLIEVYKARSQ 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crc	NP_001260672.1	bZIP_ATF4	313..374	CDD:269840	24/60 (40%)
crc	NP_001260672.1	coiled coil	315..374	CDD:269840	22/58 (38%)
ATF5	NP_001180575.1	Required for protein stabilization induced by IL1B. /evidence=ECO:0000269\|PubMed:24379400	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..152
		Interaction with PTP4A1	119..217		16/53 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..238		26/67 (39%)
		bZIP_ATF4	209..271	CDD:269840	24/61 (39%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	210..230		12/19 (63%)
		coiled coil	211..270	CDD:269840	22/58 (38%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	236..250		4/13 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I10596
eggNOG	1	0.900	-	-		E1_KOG4571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002572
OrthoInspector	1	1.000	-	-		otm40311
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13044
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5457
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.940