DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crc and Atf4

DIOPT Version :9

Sequence 1:	NP_001260672.1	Gene:	crc / 47767	FlyBaseID:	FBgn0000370	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_001274109.1	Gene:	Atf4 / 11911	MGIID:	88096	Length:	349	Species:	Mus musculus

Alignment Length:	356	Identity:	85/356 - (23%)
Similarity:	132/356 - (37%)	Gaps:	85/356 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 FPLTDSNDTEW-LYDDNFANGITLIGDDEALTLEEVASLQLLSDEEMVVEIFDLKDEECLLDQKA 101
            |....:..:|| ..||..|:. :..|.::|           .|..:.::|..|||:
Mouse    49 FSSDKAGSSEWPAMDDGLASA-SDTGKEDA-----------FSGTDWMLEKMDLKE--------- 92

  Fly   102 TLNCIDYDSNSFQPNINVITQAIVPANKVQFGASSDAASLPSAADYQLNDGPSLILQQLTP---- 162
                .|:|:.....::..:...::.       ...|...|.:....:.|..|.   |.:.|
Mouse    93 ----FDFDALFRMDDLETMPDELLT-------TLDDTCDLFAPLVQETNKEPP---QTVNPIGHL 143

  Fly   163 PQSPPQFDAYKQAGDAQPKPVLVKAEQKVQCYTPDVTHAASATPFNFTNWVGGSEI-ARENQLVD 226
            |:|..:.|........||.|          | :|.|   .|:||.:..:...|||: ..|.....
Mouse   144 PESLIKVDQVAPFTFLQPFP----------C-SPGV---LSSTPEHSFSLELGSEVDISEGDRKP 194

  Fly   227 DIVNMRAKELELSTNWQQLNEDCESQASSSLDSRSTGSGVC-------------SSIADADEDWV 278
            |           |..:..|...|..:..:..|:   .||:|             .|.:.|..|.:
Mouse   195 D-----------SAAYITLIPPCVKEEDTPSDN---DSGICMSPESYLGSPQHSPSTSRAPPDNL 245

  Fly   279 PELISSSSSPAPTTIEQSASQPKKRTRTYGRGVEDRKIRKKEQNKNAATRYRQKKKLEMENVLGE 343
            |....|..||.|...:........:.:|...   |:|::|.||||.|||||||||:.|.|.:.||
Mouse   246 PSPGGSRGSPRPKPYDPPGVSLTAKVKTEKL---DKKLKKMEQNKTAATRYRQKKRAEQEALTGE 307

  Fly   344 EHVLSKENEQLRRTLQERHNEMRYLRQLIRE 374
            ...|.|:||.|:........|::||:.||.|
Mouse   308 CKELEKKNEALKEKADSLAKEIQYLKDLIEE 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crc	NP_001260672.1	bZIP_ATF4	313..374	CDD:269840	30/60 (50%)
crc	NP_001260672.1	coiled coil	315..374	CDD:269840	29/58 (50%)
Atf4	NP_001274109.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..75		7/26 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..271		13/69 (19%)
		BetaTrCP degron motif. /evidence=ECO:0000269\|PubMed:23663782	214..223		4/11 (36%)
		bZIP_ATF4	277..339	CDD:269840	31/62 (50%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	278..298		14/19 (74%)
		coiled coil	279..338	CDD:269840	29/58 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..298		14/18 (78%)
		Interaction with GABBR1. /evidence=ECO:0000250	303..339		13/36 (36%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	304..332		8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I10539
eggNOG	1	0.900	-	-		E1_KOG4571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002572
OrthoInspector	1	1.000	-	-		otm42376
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13044
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5457
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.940