DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment c(3)G and ATGRIP

DIOPT Version :9

Sequence 1:	NP_650490.1	Gene:	c(3)G / 47765	FlyBaseID:	FBgn0000246	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_851277.1	Gene:	ATGRIP / 836733	AraportID:	AT5G66030	Length:	788	Species:	Arabidopsis thaliana

Alignment Length:	737	Identity:	174/737 - (23%)
Similarity:	304/737 - (41%)	Gaps:	145/737 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VAQEKNSQIPTVWKKDHV---KTQLFERSNEKPSKKRTPLVAPRVQQSKIEAQTSQAVEKTQEDQ 87
            ::::|.|.:....::.||   ..:|.:.|||..::....|: ..:.:.::|....::..:..:|:
plant     1 MSEDKESDVVGEEEESHVIKEDKELNDASNETLTENGDQLL-QMIAELRLENDFLRSQFEGLKDE 64

  Fly    88 TFAATIDSSTKSLKKSPKNEGELWADIQKLSPHTGIIIHSFIKQYNESLNNLKKKDLVVSKKMRA 152
            .      :..:||:|:.:.|    ||..:|            ||..|.:.:| .:::.|.|:.|.
plant    65 V------AQGRSLQKAEQVE----ADSAQL------------KQLQEQVASL-SREIDVEKQTRV 106

  Fly   153 IAMDSLK----------KKSENISLKEKLTNMELELTQLKTDLIEQQEKNAENIQKYTEINKKYT 207
            .|..:|:          .||:..|  .|.:.:|.:|.|   ::.|:.||.|:...|:|.::|:..
plant   107 AAEQALEHLREAYSEADAKSQEYS--SKFSQVEQKLDQ---EIKERDEKYADLDAKFTRLHKRAK 166

  Fly   208 HCEQHYDKELEIIKVCVEKKNSELRDAQSRMALQAQELNNMQQTNRELAGACENYKKDLEEAEVA 272
            ...|...||.:.:.....:.|.....|.|:.:...|||...:|...|...|.:..::.|..|.
plant   167 QRIQEIQKEKDDLDARFREVNETAERASSQHSSMQQELERTRQQANEALKAMDAERQQLRSAN-- 229

  Fly   273 KSMILHELTD-LKELHEDLQLQFEDVSAQKEKFEANILQLSSDLNAKMLDCAQ-LEDRIEQL-PI 334
                 ::|.| ::||...||       .::.|.|.        |...:||..| |||..:|| .:
plant   230 -----NKLRDTIEELRGSLQ-------PKENKIET--------LQQSLLDKDQILEDLKKQLQAV 274

  Fly   335 EANKAL------SKLQRDLEASELQFVDQQRLTDQATRELELVRNEINTFKTLIEEKERRHVSLS 393
            |..|.:      :|.|::||..|.|.||       |..|.:.....|::.:.|:.|||.:...:.
plant   275 EERKQIAVTELSAKHQKNLEGLEAQVVD-------ALSERDKAAETISSLQVLLAEKESKIAEME 332

  Fly   394 DELTQMTERLSELADINESYINELTETKLKHSQEIKDQADAYEIVVQELKESLNKASVDFTQLKS 458
            ...|....||...|   |:...||...|.::.:|    .:.:|.....||..|..|..::.|.:.
plant   333 AAATGEAARLRAAA---ETLKGELAHLKSENEKE----KETWEASCDALKSKLEIAESNYLQAEI 390

  Fly   459 NSEK----LHKETLLQVSELQEKLIEMVSHRSNQEELIKRLGNEIQEKTHNFEEELKRQQEQLA- 518
            ...|    |..|..:|...|..|..|:...|    |.|.||.:|...........|:::..:||
plant   391 EVAKMRSQLGSEMSMQTQILSTKDAELKGAR----EEINRLQSEFSSYKIRAHALLQKKDMELAA 451

  Fly   519 --NQMQMKATE------------VESENKRNAVEIQ----KLKSELEERNKAFKAQQDKLEYLIS 565
              :..|:|:.|            |.:|..|...::|    .|:.|||||..|.|   |..|.:.|
plant   452 AKDSEQIKSLEEALKEAEKEVYLVSAERDRAQQDLQSALASLEKELEERAGALK---DASEQIKS 513

  Fly   566 DHDTLKSAIINLQAEKKEIESELSTAKVKF---SEELQSQKDNLMKKVSELELEIKRKETELIEL 627
            ....|.|.:...||||:..|.:|...:..:   .|.|.:|.:....:..|.|||..:...:.::.
plant   514 LEVKLDSTVARNQAEKQAWEEDLRVLEETWRRRCEALTAQNEASPAEGIEKELENAKLRNKRMKE 578

  Fly   628 EREKNNEMA--VLQFKMNRINCLIDQPVTTIKQLKDSK-------------GPTRTESIPTKVQP 677
            |.|...|:|  :::.|...|:.|:|: :|.:::..:||             |...|||     |.
plant   579 EHESVRELADRLIEEKDREISRLVDE-MTNLRKSMESKPVWNKSPSQVHHYGNNNTES-----QQ 637

  Fly   678 ENTDEFSSTARKRN----ARRQ 695
            ::....|::|.:..    ||:|
plant   638 QDVSNLSTSAAEHQILILARQQ 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
c(3)G	NP_650490.1	iSH2_PI3K_IA_R	363..>516	CDD:304922	36/156 (23%)
ATGRIP	NP_851277.1	TMPIT	166..>257	CDD:285135	23/112 (21%)
ATGRIP	NP_851277.1	Grip	712..755	CDD:197860
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23160
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100