DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment c(3)G and lama5

DIOPT Version :9

Sequence 1:	NP_650490.1	Gene:	c(3)G / 47765	FlyBaseID:	FBgn0000246	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	XP_009294934.1	Gene:	lama5 / 321243	ZFINID:	ZDB-GENE-030131-9823	Length:	3665	Species:	Danio rerio

Alignment Length:	684	Identity:	136/684 - (19%)
Similarity:	266/684 - (38%)	Gaps:	187/684 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 WADIQKLSPHTGIIIHSFIKQYNESLNNLKKKDLVVSKKMRAIAMD--SLKKKSENISLKEKLTN 173
            |..:.:|:.....|.:: |..||.:|:..:.:..|:..::..|..|  .|:||:
Zfish  2181 WTQLNRLNASIADIANA-ITNYNSTLDKSRNRASVLEGELEIIDSDIKDLEKKA----------- 2233

  Fly   174 MELELTQLKTDLIEQQEKNAENIQKYTEINKKYTHCEQHYDKELEIIKVCVEKKNSELRDAQSRM 238
               .:||.|.|.:|.            .||..:|..::.:.    .||       ..:||.:
Zfish  2234 ---SVTQKKKDALED------------NINSTHTRAQELFG----FIK-------GIMRDVK--- 2269

  Fly   239 ALQAQELNNMQQTNRELAGACENYKKDLEEAEVAKSMILHELTDLKELHEDLQLQFEDVSAQKEK 303
                   :.:||.||    ..:|..:.::|.::|:     ::.:::.:..|::.:..|....|.|
Zfish  2270 -------DIIQQVNR----TAQNETQVMDEKDLAR-----KIAEVESMLRDMRFRGFDYQKNKAK 2318

  Fly   304 FE---ANIL----------------QLSSDLNAKMLDCAQLEDRIEQLPIEANKALSKLQRDLEA 349
            .|   ||.|                .::.::..|:   .|..:::..|....|:|::...:.:||
Zfish  2319 NELDQANNLVDRVINEIANRTWNNEAVAENIRNKL---KQFNEQLMDLRDAMNEAVNNTAQTVEA 2380

  Fly   350 SELQFVDQQRLTDQATRELELVRNEINTFKTLIEEKERRHVS----LSDELTQMTERLSELADIN 410
            :.   ::|:.|.|        ::.::|:    :.||.:..||    ..|::||:.:.||.|.|..
Zfish  2381 NN---INQKHLED--------LQKKVNS----LHEKYKEVVSQLQMAEDDVTQVNDLLSMLQDSK 2430

  Fly   411 ESYINELTETKLKHSQEIKDQADAYEIVVQELKESLNK--ASVDFTQLKSNSEKLHKETLLQVSE 473
            |.|            :.:..|.|...   |.|.|.:.|  .:.:...|...:|| |.|.|.|::.
Zfish  2431 EDY------------EHLAAQLDGAR---QPLAEKVQKYAPAANKIPLVEAAEK-HAEMLEQLAN 2479

  Fly   474 LQEKLIEMVSHRSNQEELIKRLGNEIQEKTHNFEEELKRQQEQLANQMQMKATEVES---EN--- 532
            ....||.    .|||:..|:|..|..:..|:.....|:      |....:||.|..|   ||
Zfish  2480 NLSSLIS----GSNQDNFIQRALNASRAYTNIINSVLE------AETTALKANETASMALENIRD 2534

  Fly   533 ----------KRNAVEIQKLKSELEERNKAFKAQQDKLEYLISDHDTLKSAIINLQAEKKEIESE 587
                      |..:.|:.|...||...:::.|.:.|.::..:.|.:..|..::.   :.|:|:::
Zfish  2535 KDLPAQAAALKNQSTELLKSAEELNNSSQSLKPRVDTIKMSLLDAEKKKEKMLQ---DLKDIQNK 2596

  Fly   588 LSTAK------VKFSEELQSQKDNLMKKVSELELEIKRKETELIELEREKNNEMAVLQFKMNRIN 646
            |:.::      :..::....|.:|.:..||.:...|::   :|.|.:::..:..|..:    .||
Zfish  2597 LNVSRDDIVNSISAAKSAVEQANNTVANVSGVLAPIQK---QLEEWQKQYGDSNATSE----DIN 2654

  Fly   647 CLIDQPVTTIKQLKDSKGPTRTESIP----TKVQPENTDEFSSTARK-----RNARRQKITTYSS 702
            ..::...|::..|.|:. |...:.:.    |..||.|..:.....|:     |||..:  .:.|.
Zfish  2655 KALNDANTSVAALSDTL-PKLIKKLDRLHNTTFQPSNISDSIQRIRQLIEQARNAANK--VSVSM 2716

  Fly   703 DFDSGDDIPIVGNSLSGKRAKLCAPIKPQNNIDM 736
            .|          |..||.:.:     .|.|..|:
Zfish  2717 QF----------NGKSGVQVR-----TPSNVADL 2735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
c(3)G	NP_650490.1	iSH2_PI3K_IA_R	363..>516	CDD:304922	37/158 (23%)
lama5	XP_009294934.1	Laminin_N	51..290	CDD:278484
		EGF_Lam	291..339	CDD:238012
		EGF_Lam	350..413	CDD:238012
		EGF_Lam	421..463	CDD:214543
		EGF_Lam	482..529	CDD:214543
		Laminin_EGF	529..577	CDD:278482
		Laminin_EGF	575..622	CDD:278482
		Laminin_EGF	620..667	CDD:278482
		EGF_Lam	664..711	CDD:238012
		Laminin_EGF	713..759	CDD:278482
		Laminin_EGF	762..812	CDD:278482
		EGF_Lam	815..858	CDD:238012
		Laminin_EGF	1421..1469	CDD:278482
		Laminin_EGF	1511..1561	CDD:278482
		Laminin_EGF	1559..1607	CDD:278482
		Laminin_B	1672..1796	CDD:278481
		EGF_Lam	1842..1881	CDD:238012
		Laminin_EGF	1894..1947	CDD:278482
		EGF_Lam	1949..2002	CDD:238012
		Laminin_EGF	2004..2048	CDD:278482
		Laminin_EGF	2051..2099	CDD:278482
		Laminin_EGF	2099..>2128	CDD:278482
		mycoplas_twoTM	2158..>2351	CDD:275320	40/226 (18%)
		Laminin_I	2171..2429	CDD:283627	61/322 (19%)
		COG1340	2319..2558	CDD:224259	61/282 (22%)
		BAR	2383..2637	CDD:299863	64/297 (22%)
		Laminin_II	2611..2741	CDD:283628	30/150 (20%)
		LamG	2757..2896	CDD:214598
		LamG	2932..3075	CDD:238058
		LamG	3110..3249	CDD:238058
		LamG	3320..3466	CDD:238058
		LamG	3490..3642	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910