DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Amy-p and slc3a1

DIOPT Version :9

Sequence 1:	NP_001286518.1	Gene:	Amy-p / 47764	FlyBaseID:	FBgn0000079	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_021336428.1	Gene:	slc3a1 / 557757	ZFINID:	ZDB-GENE-090313-225	Length:	674	Species:	Danio rerio

Alignment Length:	465	Identity:	93/465 - (20%)
Similarity:	158/465 - (33%)	Gaps:	143/465 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VQVSPVNENAVKDSRPWWERYQPISYKLETRSGNEEQFASMVKRCNAVGVRTYVDVVFNHMAADG 122
            :.:||..::.::|.....|.::.:    :...|..|.|..::...:..|::..:|.:.||.:...
Zfish   150 IWISPFYKSPMRDFGYDVEDFRDV----DPLFGTMEDFDDLLTSMHDKGLKLIMDYIPNHTSDKH 210

  Fly   123 GTYGTGGSTASPSSKSYPGVPYSSLDFNPTCAISNYNDA----NEVR-NCE----LVGLRDLNQG 178
            ..:....:...|.:..|..|..:: |.:|...:|.:.::    :|:| .|.    |....|||..
Zfish   211 VWFQLSRNYTEPYTDYYIWVNCTA-DKHPNNWVSVFGNSTWEYDEIRQQCYFHQFLKEQPDLNYR 274

  Fly   179 NSYVQDKVVEFLDHLIDLGVAGFRVDAAKHMWPA--------------------------DLAVI 217
            |..|..::.:.:...:..||.|||:||.|||..|                          |....
Zfish   275 NPLVLQEMTDIIHFWLKKGVDGFRMDAVKHMLEATHLRDEPQVNPDQDPSTVDTEFELYHDYTYT 339

  Fly   218 YGRLKNLNTD-------HGFASGSKAYIVQEVIDMGGEAISKS-EYTGLGAITEF---------- 264
            ...|..:.||       :....|...::|.|..|.  |.|.|: .|.|.....|.
Zfish   340 QAGLHEILTDWRIQMDTYSREPGRYRFMVMESYDY--EEIDKTMRYYGTNYAKESDFPFNFYLLD 402

  Fly   265 -------RHSDSI-----GKVFRGKDQLQYLTNWGTAWGFAASDRSLVFVDNHDNQR-GHGAGGA 316
                   .::.||     ..:.:||     ..||              .|.|||..| |..||
Zfish   403 LPDNLSGNYAKSIVERWMSNMPKGK-----WPNW--------------VVGNHDKPRIGSSAG-- 446

  Fly   317 DVLTYKVPKQYKMASAFMLAHPFGTPRVM--SSFSFTDTD----QGP-----PTTDGHNIASPI- 369
                    |:|..|...:|....|||...  ......|.:    |.|     |:.......:|:
Zfish   447 --------KEYVRALNMLLLTLPGTPTTYYGEEIGMVDVNISVIQDPAGQYDPSKSRDPQRTPMQ 503

  Fly   370 FNSD------NSCSGGWVCEHRWRQIYNMVAFRNTVGLDEIQNWWDNGSNQISFSRG-------- 420
            :|::      .|.:|.|:         ::.:...||.: |:|.  |:.|:.||..|.
Zfish   504 WNNELNAGFSESLNGTWL---------DIASDYRTVNV-EVQQ--DDTSSTISQYRALSLLRSSN 556

  Fly   421 ---SRGFVAF 427
               |||:..:
Zfish   557 VILSRGWFCY 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amy-p	NP_001286518.1	AmyAc_bac_euk_AmyA	28..399	CDD:200456	81/424 (19%)
		Alpha-amylase	54..342	CDD:278554	70/349 (20%)
		Aamy_C	405..493	CDD:214749	9/34 (26%)
slc3a1	XP_021336428.1	SLC3A2_N	55..113	CDD:318284
slc3a1	XP_021336428.1	AmyAc_SLC3A1	106..563	CDD:200494	92/460 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900